ets2
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  • Official Full Name
  • v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
  • Background
  • This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded;protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is;located on the X chromosome. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • ETS2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); v ets avian erythroblastosis virus E26 oncogene homolog 2; protein C-ets-2; C ets 2 protein; ETS2_HUMAN; ETS2IT1; Oncogene ETS2; v ets avian erythroblastosis virus E2 oncogene homolog 2; V ets erythroblastosis virus E26 oncogene homolog 2; oncogene ETS-2; v-ets avian erythroblastosis virus E2 oncogene homolog 2; v-ets avian erythroblastosis virus E26 oncogene homolog 2
Cat.#:ETS2-3529HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ETS2 Protein, GST-tagged
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Cat.#:ETS2-12569HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ETS2, GST-tagged
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Cat.#:ETS2-247HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ETS2, His-tagged
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Cat.#:ETS2-902HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ETS2 Protein, His-tagged
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Cat.#:ETS2-5348MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ETS2 Protein
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Cat.#:ETS2-6864CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ETS2
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Cat.#:ETS2-2948ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ETS2
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Cat.#:ETS2-6525HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ETS2 293 Cell Lysate
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Involved Pathway

ETS2 involved in several pathways and played different roles in them. We selected most pathways ETS2 participated on our site, such as Ras signaling pathway, Dorso-ventral axis formation, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PIK3CD; GNG13; PLCE1; PLA2G6; NGFR; PLCG2; NF1; PDGFA; MET; FGF13
Dorso-ventral axis formation
NOTCH3; SOS1; SPIRE1; PIWIL4; GRB2A; MAP2K1; PIWIL1; CPEB2; SPIRE1A; PPP1R2P9
HTLV-I infection
WNT7B; HLA-B; ITGAL; TBPL1; CCND2; IL6; HLA-DQB1; H2-AB1; TRP53INP1; HLA-E

Protein Function

ETS2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETS2 itself. We selected most functions ETS2 had, and list some proteins which have the same functions with ETS2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein VOX; NKX6.1; SIX4; HER5; MNX2A; FOXO1A; SPRTN; SSRP1A; HOXB1B; DNAJB6
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HELT; JUNBA; JDP2; TFE3B; NEUROG3; MITFB; MED8; EN1; DPF2; NFIB
Function glucocorticoid receptor binding
Related Protein GRIP1; FKBP4; CEBPB; EP300; STAT3; YWHAH; STAT5B; NR4A2; ETS2; NRIP1
Function protein binding
Related Protein PMAIP1; USP6; NPLOC4; LINC00482; KCND2; SPON2; FBN1; PGRMC1; RECK; RAB1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF577; GTF2H3; TRIM22; MESPBA; FOXI3A; KLF7; TBX5B; TBX16; ZNF35; TBX18
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein E2F8; GATA1; ASCL1; ZKSCAN3; SNAI2; NACC2; ZFPM2; HMGA2; TFAP2A; SPI1

Interacting Protein

ETS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETS2.
RFWD2; CDK10; TWIST1; TWIST2; RFWD2; ZFYVE9; sSL2; htrA; clpB; q7clb3_yerpe; proA; phnI; ubiG; gcvP; raf1_human_gene

ETS2 Related Articles

Donnison, M; Broadhurst, R; et al. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. DEVELOPMENTAL BIOLOGY 397:77-88(2015).
Kim, JY; Lee, RH; et al. OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1(+), hematopoietic, and endothelial cells from embryonic stem cells. BLOOD 124:2948-2952(2014).