ETS2

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ETS2

Official Full Name v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
Background This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded;protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is;located on the X chromosome. Alternative splicing results in multiple transcript variants.
Synonyms ETS2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); v ets avian erythroblastosis virus E26 oncogene homolog 2; protein C-ets-2; C ets 2 protein; ETS2_HUMAN; ETS2IT1; Oncogene ETS2; v ets avian erythroblastosis virus E2 oncogene homolog 2; V ets erythroblastosis virus E26 oncogene homolog 2; oncogene ETS-2; v-ets avian erythroblastosis virus E2 oncogene homolog 2; v-ets avian erythroblastosis virus E26 oncogene homolog 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ETS2-12569H Recombinant Human ETS2, GST-tagged E.coli GST
    Human ETS2-247H Recombinant Human ETS2, His-tagged E.coli His
    Human ETS2-3529H Recombinant Human ETS2 Protein, GST-tagged Wheat Germ GST
    Human ETS2-6525HCL Recombinant Human ETS2 293 Cell Lysate HEK293 N/A
    Human ETS2-902H Recombinant Human ETS2 Protein, His-tagged E.coli His
    Mouse ETS2-5348M Recombinant Mouse ETS2 Protein Mammalian Cell His
    Chicken ETS2-6864C Recombinant Chicken ETS2 Mammalian Cell His
    Zebrafish ETS2-2948Z Recombinant Zebrafish ETS2 Mammalian Cell His

    ETS2 involved in several pathways and played different roles in them. We selected most pathways ETS2 participated on our site, such as Ras signaling pathway, Dorso-ventral axis formation, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway FGF8; PLCG2; RAC3; PDGFA; FGF4; RAC2; RASGRF2; RHOA; ARF6; NF1
    Dorso-ventral axis formation MAPK1; SOS1; MAP2K1; NOTCH1; CPEB2; MAPK3; PIWIL2; ETV6; SPIRE2; GRB2B
    HTLV-I infection MYB; VAC14; VDAC3; HLA-C; WNT7A; RELA; TLN1; HLA-DRA; VDAC2; HLA-DPB1

    ETS2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETS2 itself. We selected most functions ETS2 had, and list some proteins which have the same functions with ETS2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ISL1L; ZNF483; THAP6; ATM; PCXA; GON4L; VEZF1; DEM1; RTEL1; ZFP367
    RNA polymerase II core promoter proximal region sequence-specific DNA binding RFX6; ETV2; TLX1; IFI203; HSF1; ZNF543; PAXBP1; RFX8; NR6A1; T
    glucocorticoid receptor binding STAT5B; STAT3; NR4A2; NRIP1; EP300; GRIP1; YWHAH; CEBPB; FKBP4; ETS2
    protein binding ERCC5; TTC19; TMUB2; FGF13; CXCL14; IL4R; IL18R1; C9orf142; RBM39; PIDD1
    transcription factor activity, sequence-specific DNA binding UBP1; TEFA; ZNF286A; POU6F2; ZNF187; ZBTB48; ATF6; RXRAA; ARNTL1A; GLI3
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZNF148; BTG2; NFIL3-5; RCOR1; GATA3; E2F8; YY1; BATF3; ZFPM2; NKX6

    ETS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETS2.

    RFWD2; CDK10; TWIST1; TWIST2; RFWD2; ZFYVE9; sSL2; htrA; clpB; q7clb3_yerpe; proA; phnI; ubiG; gcvP; raf1_human_gene

    Donnison, M; Broadhurst, R; et al. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. DEVELOPMENTAL BIOLOGY 397:77-88(2015).
    Kim, JY; Lee, RH; et al. OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1(+), hematopoietic, and endothelial cells from embryonic stem cells. BLOOD 124:2948-2952(2014).

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