EXO1
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Official Full Name
exonuclease 1 -
Overview
This gene encodes a protein with 5 to 3 exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative sp -
Synonyms
EXO1;exonuclease 1;Exo 1;Exo I;EXO1_HUMAN;ExoI;Exonuclease I;Exonuclease1;ExonucleaseI;HEX 1;HEX1;hExo 1;hExo I;hExo1;hExoI;Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1;mExo1;Msa;5730442G03Rik
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXO1-12H | Recombinant Human EXO1 protein, His-tagged | E.coli | Human | His | 1-250 a.a. | |
| EXO1-12637Z | Recombinant Zebrafish EXO1 | Mammalian Cells | Zebrafish | His |
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| EXO1-13H | Recombinant Human EXO1 protein, GST-tagged | Wheat Germ | Human | GST | 747-846 a.a. |
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| EXO1-5367M | Recombinant Mouse EXO1 Protein | Mammalian Cells | Mouse | His |
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| EXO1-580HCL | Recombinant Human EXO1 cell lysate | Human | Non |
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| EXO1-2892M | Recombinant Mouse EXO1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| EXO1-2892M-B | Recombinant Mouse EXO1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Exo1-714R | Recombinant Rat Exo1 Protein, His-tagged | E.coli | Rat | His | Met1~Ile250 |
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Involved Pathway
EXO1 involved in several pathways and played different roles in them. We selected most pathways EXO1 participated on our site, such as Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mismatch repair | MSH2,POLD2,RFC2,RFC1,RPA4,POLD1,RFC5,RFC3,RPA3,MLH1 |
Protein Function
EXO1 has several biochemical functions, for example, 5-3 exodeoxyribonuclease activity,5-3 exonuclease activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXO1 itself. We selected most functions EXO1 had, and list some proteins which have the same functions with EXO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF184,TBX16,ATRX,HIST1H2AA,EBF3A,RAG2,HER2,HOXB3A,ARX,HOXA3A |
| exonuclease activity | ISG20L2,CNOT6,XRN1,REXO1L1,CNOT6L,AEN,EXOSC9,RAD9,MEIOB,REX1 |
| 5-3 exonuclease activity | FAN1,POLN,DOM3Z,DXO,CPSF3,FEN1,DCLRE1C,XRN2 |
| structure-specific DNA binding | ENDOV,SETMAR,TDG,TET1 |
| metal ion binding | Ar,MINA,ZDHHC8B,CYP2AA9,CYP2J6,STAMBPL1,ZNF221,CYP46A1.3,ZSCAN10,DDR1 |
| protein binding | AP5S1,NDUFS7,UBE2H,CERK,C17orf81,NATD1,SNTB2,SULT1A3,NAA30,ZUFSP |
| RNA-DNA hybrid ribonuclease activity | RNASEH2C,RNASEH2B,RNASEH2A,RNASEH1,APEX1,FEN1 |
| single-stranded DNA 5-3 exodeoxyribonuclease activity | DEM1,EXO5 |
| 5-3 exodeoxyribonuclease activity | DCLRE1A,DCLRE1C |
Interacting Protein
EXO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXO1.
RBBP8;CD14;CFTR;COMT;YWHAB;Tmem109;LLGL2;KLC3;ACTR5;MYEF2;RPA2;H2AFX
Resources
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References
- Upton, DC; Unniraman, S; et al. Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
- Eccleston, J; Yan, C; et al. Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining. JOURNAL OF IMMUNOLOGY 186:2336-2343(2011).
