EXO1 Protein, exonuclease 1


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Official Full Name exonuclease 1
Background This gene encodes a protein with 5 to 3 exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative sp
Synonyms EXO1; exonuclease 1; Exo 1; Exo I; EXO1_HUMAN; ExoI; Exonuclease I; Exonuclease1; ExonucleaseI; HEX 1; HEX1; hExo 1; hExo I; hExo1; hExoI; Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1; mExo1; Msa; 5730442G03Rik
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EXO1-12H Recombinant Human EXO1 protein, His-tagged E.coli His
    Human EXO1-13H Recombinant Human EXO1 protein, GST-tagged Wheat Germ GST
    Human EXO1-580HCL Recombinant Human EXO1 cell lysate N/A
    Mouse EXO1-5367M Recombinant Mouse EXO1 Protein Mammalian Cell His
    Rat Exo1-714R Recombinant Rat Exo1 Protein, His-tagged E.coli His
    Zebrafish EXO1-12637Z Recombinant Zebrafish EXO1 Mammalian Cell His

    EXO1 involved in several pathways and played different roles in them. We selected most pathways EXO1 participated on our site, such as Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair PMS2; LIG1; POLD1; POLD4; SSBP1; RPA2; RFC5; EXO1; RPA1; MSH3

    EXO1 has several biochemical functions, for example, 5-3 exodeoxyribonuclease activity, 5-3 exonuclease activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXO1 itself. We selected most functions EXO1 had, and list some proteins which have the same functions with EXO1. You can find most of the proteins on our site.

    Function Related Protein
    5-3 exodeoxyribonuclease activity DCLRE1A; DCLRE1C; EXO1
    5-3 exonuclease activity XRN2; DCLRE1C; DXO; EXO1; FEN1; CPSF3; POLN; FAN1; DOM3Z
    DNA binding CBFB; CERS5; MSGN1; ZNF580; ZC3H3; MECOM; SETDB1; RBM5; MCM3L; ZNF574
    RNA-DNA hybrid ribonuclease activity RNASEH2A; APEX1; RNASEH2C; EXO1; RNASEH1; RNASEH2B; FEN1
    double-stranded DNA 5-3 exodeoxyribonuclease activity EXO1
    exonuclease activity REXO1L1; EXO5; CNOT6L; CNOT6; MEIOB; FEN1; REX1; XRN1; ISG20L2; REXO1
    flap endonuclease activity EXO1
    metal ion binding NOS2B; PRKCDA; CYP2B19; CYGB1; PDLIM5B; CLCA3; NUDT10; SCRT1A; ME2; ELP3
    protein binding PHF15; PRKACB; SOAT1; GSTK1; PTPN23; TFG; ELN; EAF1; PDLIM4; ANXA9
    single-stranded DNA 5-3 exodeoxyribonuclease activity EXO1; EXO5; DEM1
    structure-specific DNA binding TET1; EXO1; ENDOV; TDG; SETMAR

    EXO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXO1.


    Upton, DC; Unniraman, S; et al. Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
    Eccleston, J; Yan, C; et al. Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining. JOURNAL OF IMMUNOLOGY 186:2336-2343(2011).

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