Ep300 Protein, E1A binding protein p300


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Official Full Name E1A binding protein p300
Background This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Synonyms EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ep300-49M Recombinant Mouse Ep300 Protein, GST-tagged E.coli GST
    Human EP300-1074H Recombinant Human E1A Binding Protein P300, 302-531aa E.coli N/A
    Human EP300-1584H Recombinant Human E1A Binding Protein P300, GST-tagged Sf9 Insect Cell GST
    Human EP300-1585H Recombinant Human E1A Binding Protein P300, GST-tagged Sf9 Insect Cell GST
    Human EP300-202H Recombinant Human EP300 protein, DDK-tagged Insect Cell DDK
    Human EP300-28677TH Recombinant Human EP300 protein, Flag-tagged Insect Cell Flag
    Human EP300-28678TH Recombinant Human EP300 N/A
    Human EP300-28680TH Recombinant Human EP300, FLAG-tagged Flag
    Human EP300-3346H Recombinant Human EP300 Protein, GST-tagged Wheat Germ GST
    Human EP300-414H Recombinant Human EP300 Protein, His-tagged E.coli His
    Human EP300-42H Recombinant Human EP300 protein E.coli N/A
    Human EP300-43H Recombinant Human EP300 Protein, GST-tagged E. coli GST
    Human EP300-442H Recombinant Human EP300, His-tagged Sf21 Insect Cell His
    Human EP300-610H Recombinant Human EP300 Mammalian Cell His
    Human EP300-80H Recombinant Human EP300 protein, His-tagged E.coli His
    Mouse Ep300-415M Recombinant Mouse Ep300 Protein, His-tagged E.coli His
    Rat Ep300-416R Recombinant Rat Ep300 Protein, His/GST-tagged E.coli His/GST
    Rhesus Macaque EP300-1481R Recombinant Rhesus monkey EP300 Protein, His-tagged Mammalian Cell His

    Ep300 involved in several pathways and played different roles in them. We selected most pathways Ep300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ep300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway MAPK3; ATP1B4; PPP1CC; PDE4B; PDE3B; SUCNR1; PRKACB; CALML5; ACOX3; GRIN2B
    HIF- signaling pathway PIK3R5; ENO3; ANGPT2; PRKCG; PIK3CA; NPPA; ANGPT4; MAPK3; PIK3CG; FLT1
    FoxO signaling pathway PTENB; MAPK1; PRKAB1; PRKAG1; MAP2K2; MAPK14B; INS; BNIP4; MAPK10; SMAD4
    Cell cycle CEP63; CDK5RAP2; DKC1; CEP290; NCAPD3; HIST3H2BB; ARPP19B; E2F4; CLSPN; KAT5
    Wnt signaling pathway CAMK2B1; FZD1; FZD5; WNT2BA; SFRP1; WNT11R; WNT11B; WNT4A; RHOA; FBXW11B
    Notch signaling pathway RBPJA; APH1B; NOTCH4; PSEN2; MAML1; LFNG; NOTCH3; KAT2B; HER15.1; MFAP5
    TGF-beta signaling pathway ACVR2B; ACVR1; ACVR2A; RHOAC; RHOA; BMPR2A; ID4; SMAD1; BMPR1BB; BMPR1AB
    Adherens junction CDC42L2; BAIAP2; INSRB; PVRL4; CTNNA1; SNAI1; SSX2IP; PVRL3B; RAC3B; WASLA
    Jak-STAT signaling pathway Il23a; Il12b; EP300; PIAS1; PIK3R3; Ifna11; FHL1B; IFNA21; AOX3; STAT5B; IL12A
    Long-term potentiation CALML5; GRIN2B; PPP3CB; RPS6KA3; PRKACB; CALML3; CAMK4; ARAF; RAF1; PPP1CC
    Melanogenesis WNT10B; CALML5; WNT11B; GNA15.4; WNT2; FZD7A; WNT9B; CALM2A; KITLG; PRKACB
    Thyroid hormone signaling pathway MED24; MED12; BMP4; TBC1D4; PIK3R5; PLCE1; AKT1; ATP1B1; MED27; PLCG1
    Glucagon signaling pathway SLC2A2; ITPR1; PGAM2; LDHA; PLCB2; ATF4; LDHAL6B; PLCB1; PCK2; PPARGC1A
    Huntingtons disease UQCRC1; DNAH14; NDUFV3; ATP5G1; EP300; DNAL4; DNALC4; ATP5B; ATP5H; HDAC2
    Tuberculosis TGFB2; MAPK9; CD209B; IFNGR1; HLA-DPA1; H2-AA; LAMP2; RELA; CYCS; ITGB2L
    HTLV-I infection NFATC4; PDGFRB; WNT7A; WNT16; CD3D; TP53; ANAPC7; AKT1; H2-AA; H2-AB1
    Herpes simplex infection BMA2; STAT1A; STAT2; ALYREF; Ccl12; TRAF2; HLA-DQB1; MAPK10; HLA-DPA1; PVRL2
    Epstein-Barr virus infection MAP2K7; TAB1; HLA-DRB5; POLR2L; AKT2; PSMC6; POLR3K; POLR1D; PRKACG; HLA-DRB4
    Pathways in cancer BAD; ITGA6; WNT8A; SMO; RASGRP3; FZD7; TRAF3; PRKCA; BDKRB1; HDAC2
    Viral carcinogenesis HDAC10; HIST1H2BN; RBL2; CDK1; IKBKG; SRF; HIST1H2BL; PIK3R3; PIK3R2; SND1
    MicroRNAs in cancer MDM4; UBE2I; BCL2L2; TNC; DNMT1; IRS1; APC; MAP2K1; SOCS1; ABCB1A
    Renal cell carcinoma RAF1; HRAS; TGFA; TCEB2; ARAF; ETS1; VEGFA; TCEB1; PAK3; AHA-1
    Prostate cancer CCND1; SPRY1; GRB2; PDGFRB; SOS1; AKT2; CASP9; BAD; RAF1; NOXA1

    Ep300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ep300 itself. We selected most functions Ep300 had, and list some proteins which have the same functions with Ep300. You can find most of the proteins on our site.

    Function Related Protein
    NF-kappaB binding HDAC2; MTDH; BCL10; FAF1; CDK5RAP3; DNAJA3; ANXA4; RPS3; EP300; HDAC1
    RNA polymerase II activating transcription factor binding SMAD3; HNF4A; EP300; EGR2; PITX2; HIPK2; SETD3; LDB1; EOMES; NFE2L2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NKX6-1; ZNF395; KCNIP3; HOXD13; MYPOP; SMAD2; LEF1; FOXJ2; SKIL; CEBPG
    RNA polymerase II core promoter sequence-specific DNA binding MTF1; EGR1; NR4A2; SMAD1; SMYD3; MAZ; NFIL3; TRP53; MITF; YAP1
    acetyltransferase activity KAT8; CML2; EP300; LPCAT3; NAT14; KAT5; Acnat1; ACNAT2; AANAT1; CREBBP
    activating transcription factor binding PRDM16; TAF9; EEF1D; PPARG; HDAC7; ZFP516; MEF2D; DGKQ; SMAD2; PSIP1
    androgen receptor binding GRIP1; PRKCBB; KDM3A; NRIP1; KAT5; RB1; TCF21; NSD1; DDX5; BRCA1
    bHLH transcription factor binding EP300; MAP3K10; TCF3A; LMO2; USF1; HAND1; TWIST1; PSMD9; TCF12; TCF3
    beta-catenin binding CARM1; PXN; PTPRU; SHROOM2; ESR1; GSK3B; SOX17; CALCOCO1; AXIN2; KLF4
    chromatin DNA binding EZH2; GRHL3; H1F0; RELA; PER1; RXRA; APEX1; XBP1; MED1; ZIC2
    chromatin binding SIRT2; ZGLP1; CHD8; MLL1; TCF7L1B; STAT5B; CREBBP; TICRR; SMAD2; NR5A2
    core promoter binding NPAS2; E2F8; MYOG; IFI16; INSM1A; HDAC4; NKX3-1; ARNTL; MYBBP1A; E2F3
    damaged DNA binding DCLRE1C; PCNA; H2AFX; CRY2; NEIL2; XRCC6; OGG1; TRP53; TP73; POLI
    glucocorticoid receptor binding NR4A2; YWHAH; GRIP1; CEBPB; FKBP4; EP300; ETS2; STAT3; STAT5B; NRIP1
    histone acetyltransferase activity KAT6B; EP300; TAF1L; NCOA2; HTATIP; MED24; HAT1; KAT7A; KAT7; KAT2A
    lysine N-acetyltransferase activity, acting on acetyl phosphate as donor EP300; ESCO2; NAT8B; KAT2B; CEACAM21; NAT8; RHBDL1
    mitogen-activated protein kinase binding GTF2I; PTPRJ; DUSP2; ABL1; ACE; SIRT1; NBR1; MAPKAPK2B; PLCB4; MAPKAPK5
    nuclear hormone receptor binding CTNNB1; CRY1; HIF1A; SIRT1; TACC2; NCOR1; TCF7L2; Ankar; MYOD1; NCOA1
    p53 binding SETD7; USP10; ZFP346; TP53; AXIN1; CDK5; TP63; TRIM29; ZNF385C; ZNF385D
    peroxisome proliferator activated receptor binding ASXL2; HMGA1-RS1; HMGA1; EP300; IKBKG; NR0B2; ASXL1; MED1; CREBBP; PPARGC1A
    pre-mRNA intronic binding HNRNPA2B1; RBM41; EP300; SOX9; RNPC3; RBM4; PRPF8
    protein C-terminus binding ERCC6; DYNLL1; PLEKHB1; ERCC2; DAB2; BAIAP2; AP2A1; CEP135; PIAS3; SIAH1A
    protein antigen binding KLRC2; H2-AB1; EP300; ITGA4; KLRD1
    protein binding YWHAE; CNTNAP2; KLC1; CXCR7; RASGRP3; C1QTNF9; APBA3; KTI12; CAMK2D; TBC1D9B
    protein complex binding VHLL; RPTOR; HCLS1; EPHB1; PGAM5; PPIB; CPS1; ATF1; PDCL; FBN1
    transcription coactivator activity JUNB; NR1H3; HAND1; ENY2; FUS; ELF3; TFAP2B; PCBD1; KDM5A; MED14
    contributes_to transcription coactivator activity CREBBP; PHF2; EP300; ARID5B
    transcription factor binding CTNNB1; PPRC1; PARD6A; EPN1; PAX6; DIP2B; TRERF1; TRIB2; PPID; HTT
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding FOXO3; BARX2; RFX6; CREBBP; BHLHA15; TRP53; REST; IKZF3; CREB3L4; MAF
    transferase activity, transferring acyl groups ZDHHC18; GGT7; DGAT2L6; AANAT; EP300; CHAC2; CDYL; MBOAT7; CML5; LIPT2
    zinc ion binding MT1B; MORC2; ZDHHC24; FTR54; DNMT1; GCH2; MYLIP; LMCD1; PJA2; RNF138

    Ep300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ep300 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ep300.

    HIF1A; TP53

    Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
    Cho, YA; Hong, JS; et al. The role of p300 in the tumor progression of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE 44:185-192(2015).

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