Recombinant Mouse Ep300 Protein, GST-tagged Ep300-49M

Recombinant Mouse Ep300 Protein, GST-tagged

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Recombinant Mouse Ep300 Protein, GST-tagged

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Cat.No. : Ep300-49M
Product Overview : Recombinant mouse Ep300 protein with a C-terminal GST-tag was expressed in E. coli.
Description : p300/(CREB binding protein) associated factor (PCAF) belongs to the GCN5/PCAF family of nuclear histone acetyltransferases (HATs). Gcn5/PCAF proteins contain a-160 residue HAT domain and a conserved bromodomain directly C-terminal to the HAT domain, which has been shown recently to be an acetyl-lysine targeting motif. PCAF acetylates specific lysines on the N-terminal tails of Histones H3 & H4 and on the transcriptional activators MyoD, E2F1, and p53. Recently, PCAF was also shown to acetylate PTEN on lysine residues K125 & K128 within the catalytic cleft thus inactivating the enzyme. In many, but not all of these cases, acetylation has been shown to enhance the DNA binding affinity of the affected protein. Although the recombinant HAT proteins will acetylate free histones, nucleosomal acetylation only occurs in the context of the in vivo HAT complex.
Source : E. coli
Species : Mouse
Tag : GST
Molecular Mass : 40 kDa
Protein length : 165
Purity : ≥80% estimated by SDS-PAGE
Applications : Enzyme Activity
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM sodium phosphate, pH 7.2, with 100 mM sodium chloride, 1 mM EDTA, and 20% glycerol
Gene Name : Ep300 E1A binding protein p300 [ Mus musculus (house mouse) ]
Official Symbol : Ep300
Synonyms : Ep300; E1A binding protein p300; p300; KAT3B; p300 HAT; A430090G16; A730011L11; histone acetyltransferase p300; E1A-associated protein p300; histone butyryltransferase p300; histone crotonyltransferase p300; protein 2-hydroxyisobutyryltransferase p300; protein propionyltransferase p300
Gene ID : 328572
mRNA Refseq : NM_177821
Protein Refseq : NP_808489
UniProt ID : B2RWS6

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