• Official Full Name
  • coagulation factor VIII, procoagulant component
  • Background
  • Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.
  • Synonyms
  • Factor VIII; FVIII; F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F8 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Coagulation Factor VIII, Procoagulant Component
Source (Host):Human plasmaSpecies:Human
Product nameHuman Factor-VIII
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F8 Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F8, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F8 protein, His-tagged
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog F8 protein, His-tagged
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig F8 protein, His-tagged
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Coagulation Factor VIII, Procoagulant Component
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human F8, GST-tagged
Source (Host):Species:Human
Product nameRecombinant Human F8 293 Cell Lysate
Source (Host):Species:Human
Product nameHuman Blood Coagulation Factor VIII Reference standard
Source (Host):Species:Human
Product nameHuman Factor VIII Reference standard
Source (Host):CHOSpecies:Human
Product nameRecombinant Human F8 therapeutic protein

Involved Pathway

F8 involved in several pathways and played different roles in them. We selected most pathways F8 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
Serpina1b; F8; F13B; LOC100514666; F2; CPB2; F9; C4A; Serpina1c; CFD

Protein Function

F8 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F8 itself. We selected most functions F8 had, and list some proteins which have the same functions with F8. You can find most of the proteins on our site.
Related Protein
Function copper ion binding
Related Protein MOXD1L; ABP1; COX17; SERPINB1A; LOXL1; MT1; LOXL3A; AOC1; ATOX1; CCS
Function oxidoreductase activity
Related Protein GFOD2; HSDL2; CYP27C1; CREG1; DAO.1; CYP2Y3; DIO3A; CYP2X7; CYP2E1; YWHAE2
Function protein binding
Related Protein FRMD4B; IRF5; RBP5; ZNF436; BRAP; DPCD; HSPB8; CASP6; RPS6KB1; ASB9

Interacting Protein

F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of F8.
kv312_human; EIF1B; CALR; GGA1; UBQLN1; MAP1LC3A

F8 Related Articles

Anderson, DR; Cameron, AC; et al. WASP-20b and WASP-28b: a hot Saturn and a hot Jupiter in near-aligned orbits around solar-type stars. ASTRONOMY & ASTROPHYSICS 575:-(2015).
Hashemi, SM; Fischer, K; et al. Improved prediction of inhibitor development in previously untreated patients with severe haemophilia A. HAEMOPHILIA 21:227-233(2015).

F8 Related Gene Family

IL TNF Cytokines