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F8

  • Official Full Name

    coagulation factor VIII, procoagulant component

  • Overview

    Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.
  • Synonyms

    Factor VIII; FVIII; F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Therapeutic Proteins
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Plasma
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F8-3065H Human Factor-VIII Human Plasma N/A
Human F8-126H Recombinant Human F8, GST-tagged Wheat Germ N/A
Human F8-125H Recombinant Human Coagulation Factor VIII, Procoagulant Component CHO N/A
Human F8-2397H Recombinant Human Coagulation Factor VIII, Procoagulant Component E.coli N/A
Human F8-3624H Recombinant Human F8 Protein, GST-tagged Wheat Germ GST
Human F8-048H Recombinant Human F8 Protein, His-tagged E.coli His
Human F8-12626H Recombinant Human F8, His-tagged E.coli His C-term-208a.a.
Human F8-6482HCL Recombinant Human F8 293 Cell Lysate HEK293 N/A
Human F8-38H Human Factor VIII Reference standard N/A
Human F8-4417HF Recombinant Full Length Human F8 Protein, GST-tagged In Vitro Cell Free System GST 216 amino acids
Human F8-25H Human Blood Coagulation Factor VIII Reference standard N/A
Human F8-2309H Recombinant Human F8 Protein (Phe2253-Glu2346), N-GST tagged E.coli N-GST Phe2253-Glu2346
Human F8-1454H Recombinant Human F8 Protein, His-tagged E.coli N-His Cys2040-Cys2345
Human F8-P037H Recombinant Human F8 therapeutic protein CHO N/A 2332 aa
Mouse F8-1921M Recombinant Mouse F8 protein, His-tagged E.coli His His1854~Leu1988 linked by LASTYRLG
Mouse F8-1453M Recombinant Mouse F8 Protein, His-tagged E.coli N-His Lys399-Cys730
Rat F8-3309R Recombinant Rat F8 protein, His-tagged E.coli His His1930~Glu2252
Rabbit F8-913R Recombinant Rabbit F8 Protein, His-tagged E.coli N-His Leu2005-Glu2331
Dog F8-1920D Recombinant Dog F8 protein, His-tagged E.coli His Met2191~Cys2337 (Accession # O18806)
Cattle F8-912C Recombinant Cattle F8 Protein, His-tagged E.coli N-His Lys2010-Tyr2323
Pig F8-1922P Recombinant Pig F8 protein, His-tagged E.coli His Gly1669~Ala1824
Chicken F8-1452C Recombinant Chicken F8 Protein, His-tagged E.coli N-His Gln1766-Thr2075
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F8 Related Articles
  • F8 Related Gene Family
  • F8 Related Research Area

F8 involved in several pathways and played different roles in them. We selected most pathways F8 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesF12;A2M;C4BPB;SERPINA1A;SERPINA5;C3;C4BP;TFPI;KLKB1

F8 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F8 itself. We selected most functions F8 had, and list some proteins which have the same functions with F8. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingSNCA;MOXD2;CCC2;HEPHL1A;MT3;CP;METTL17;LOXL1;PRNP
oxidoreductase activityCYP2AD6;PCYOX1L;HIBADHA;APEX1;CYP2AA8;SDR39U1;OSGIN2;AOC1;CYP46A1.1
protein bindingPACSIN3;MPP2;PSMB8;NOTCH2NL;PBX2;FAM184A;ARID5A;TRIM31;CLDN1

F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of F8.

kv312_human; EIF1B; CALR; GGA1; UBQLN1; MAP1LC3A

Anderson, DR; Cameron, AC; et al. WASP-20b and WASP-28b: a hot Saturn and a hot Jupiter in near-aligned orbits around solar-type stars. ASTRONOMY & ASTROPHYSICS 575:-(2015).
Hashemi, SM; Fischer, K; et al. Improved prediction of inhibitor development in previously untreated patients with severe haemophilia A. HAEMOPHILIA 21:227-233(2015).
  • Q&As
  • Reviews

Q&As (5)

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How has technology advanced the production of F8 protein for therapeutic purposes? 04/26/2023

Recombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.

Can F8 protein therapy be administered at home by patients? 01/12/2020

Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.

Are there alternative treatment approaches for hemophilia A involving F8 protein? 12/13/2019

Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.

How does monitoring F8 protein levels contribute to hemophilia A management? 01/14/2019

Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.

Are there any complications associated with F8 protein replacement therapy? 01/19/2018

In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.

Customer Reviews (3)

Write a review
Reviews
01/04/2023

    The F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    04/26/2019

      Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

      06/17/2017

        With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

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