Recombinant Human F8 Protein, His-tagged


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Recombinant Human F8 Protein, His-tagged

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Cat.No. : F8-048H
Product Overview : Purified recombinant protein of Human coagulation factor VIII, procoagulant component (F8), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli.
Description : This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 24.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 50mM Tris, 8M Urea, pH 8.0.
Gene Name : F8 coagulation factor VIII, procoagulant component [ Homo sapiens ]
Official Symbol : F8
Synonyms : F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B;
Gene ID : 2157
mRNA Refseq : NM_000132
Protein Refseq : NP_000123
MIM : 300841
UniProt ID : P00451
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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