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Recombinant Human F8 Protein, His-tagged

Cat.No. : F8-1454H
Product Overview : Recombinant Human F8 Protein (Cys2040-Cys2345) with N-His tag was expressed in E. coli.
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Description : This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 38.4 kDa
Accurate Molecular Mass: 36 kDa
Protein length : Cys2040-Cys2345
Purity : > 80%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : F8 coagulation factor VIII, procoagulant component [ Homo sapiens (human) ]
Official Symbol : F8
Synonyms : F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B;
Gene ID : 2157
mRNA Refseq : NM_000132
Protein Refseq : NP_000123
MIM : 300841
UniProt ID : P00451

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
01/04/2023

    The F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    04/26/2019

      Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

      06/17/2017

        With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

        Q&As (5)

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        How has technology advanced the production of F8 protein for therapeutic purposes? 04/26/2023

        Recombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.

        Can F8 protein therapy be administered at home by patients? 01/12/2020

        Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.

        Are there alternative treatment approaches for hemophilia A involving F8 protein? 12/13/2019

        Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.

        How does monitoring F8 protein levels contribute to hemophilia A management? 01/14/2019

        Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.

        Are there any complications associated with F8 protein replacement therapy? 01/19/2018

        In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.

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