fgd4
Share
  • Official Full Name
  • FYVE, RhoGEF and PH domain containing 4
  • Background
  • This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.
  • Synonyms
  • FGD4; FYVE, RhoGEF and PH domain containing 4; FGD1 family, member 4; FYVE, RhoGEF and PH domain-containing protein 4; CMT4H; frabin; FRABP; ZFYVE6; FGD1-related F-actin-binding protein; actin-filament binding protein frabin; zinc finger FYVE domain-conta
Cat.#:FGD4-4092HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGD4 Protein, GST-tagged
+Inquiry
Cat.#:FGD4-5834MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGD4 Protein
+Inquiry
Cat.#:FGD4-2322RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGD4 Protein
+Inquiry
Cat.#:FGD4-6253HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FGD4 293 Cell Lysate
+Inquiry

Involved Pathway

FGD4 involved in several pathways and played different roles in them. We selected most pathways FGD4 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE
ITSN1; FGD4A; ARHGEF18A; ARHGEF17; NET1; ARHGEF18; TIAM2; OBSCN; AKAP13; ARHGEF16
G alpha (12/13) signalling events
RHOGA; KALRNB; PLEKHG2; KALRN; TRIO; GNA13B; FGD2; ADRA1B; ARHGAP4A; GNA13
GPCR downstream signaling
PROKR1A; FGD2; GRP; RGS17; CHRM4; PIK3R6; CCL19A.2; ADRB3; CALCB; OR7D2
NRAGE signals death through JNK
ARHGAP4; NET1; AATF; ARHGEF16; ARHGEF1A; FGD4; ARHGEF9; OBSCN; ARHGEF3; ARHGEF18A
Rho GTPase cycle
TAGAPB; AKAP13; RHOJ; ARHGAP9; ARHGEF18; ARHGAP31; DCLRE1B; RHOT1; DEPDC1B; GDI2
Signal Transduction
RLBP1A; CRABP1B; RSPO3; OXGR1; ARHGAP15; FAM123B; TAX1BP1B; EMR1; GAS8; RPGRIP1L
Signaling by GPCR
EMR3; FGD2; RGS1; NMB; CXCL11.8; RGS12; DCLRE1B; GPR31; INSL5; GPR55A
Signaling by Rho GTPases
ARHGAP29B; RHOT2; NCKIPSD; RHOT1; STARD8; DEPDC1B; ARHGAP17A; ARHGAP20; FGD4A; CHN1

Protein Function

FGD4 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, actin binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGD4 itself. We selected most functions FGD4 had, and list some proteins which have the same functions with FGD4. You can find most of the proteins on our site.
Function
Related Protein
Function Rho guanyl-nucleotide exchange factor activity
Related Protein ARHGEF16; ARHGEF3; FGD2; FGD5; ARHGEF1B; QUO; VAV3B; RASGRF2B; ITSN1; PREX1
Function actin binding
Related Protein ACTN3A; CFL1; MYHZ1.1; TNS4; WASF3; VCL; CAPGA; SPTBN2; WIPF2B; NF2
Function guanyl-nucleotide exchange factor activity
Related Protein RASGRP3; VAV2; ANKRD27; TRIO; DENND6A; DOCK11; GCGR; RASGRF2B; RAPGEF4; DENND4B
Function metal ion binding
Related Protein EXT1B; ZMIZ2; ADAP1; MAT2AL; ZNF557; RXRAB; RBM4.1; NEK2; NRXN3; PDE1B
Function small GTPase binding
Related Protein FGD2; TSC2; ABCA1; GDI2; FGD6; RNF152; FLNA; FGD4; PEX5; PEX5L

Interacting Protein

FGD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGD4.
pi3p

FGD4 Related Articles

Noseda, R; Belin, S; et al. DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination. JOURNAL OF NEUROSCIENCE 33:15295-15305(2013).
Arai, H; Hayashi, M; et al. The first Japanese case of Charcot Marie Tooth disease type 4H with a novel FGD4 c.837-1G > A mutation. NEUROMUSCULAR DISORDERS 23:652-655(2013).