gab2
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  • Official Full Name
  • GRB2-associated binding protein 2
  • Background
  • The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their
  • Synonyms
  • GAB2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Grb2 associated binder 2; KIAA0571; pp100; Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2
Cat.#:GAB2-4620HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GAB2 Protein, GST-tagged
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Cat.#:Gab2-1851MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gab2 protein, His & T7-tagged
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Cat.#:GAB2-2439RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GAB2 Protein
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Cat.#:GAB2-6074HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAB2 293 Cell Lysate
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Involved Pathway

GAB2 involved in several pathways and played different roles in them. We selected most pathways GAB2 participated on our site, such as Ras signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PGF; NGF; RAB5B; FGF8; PTPN11; RGL2; PAK7; NFKB1; GNG4; PLA2G4C
Sphingolipid signaling pathway
BID; MAP2K1; LASS1; SPTLC2; MAPK10; ASAH1; RAC3; PPP2R2C; RAC2; CERS4
Phospholipase D signaling pathway
CYTH3; INS1; PPAP2B; AVPR2; PDGFRB; SHC3; CYTH4; PTK2B; LPAR5; PIK3R5
Osteoclast differentiation
NCF4; MAPK13; FCGR1; SPI1; FCGR2B; IFNGR1; MAPK9; TAB2; PPP3CA; TREM2
Fc epsilon RI signaling pathway
PIK3R3; MAP2K6; PRKCA; GM-CSF; PDPK1; MAP2K4; MAPK13; SYK; VAV2; KRAS
Fc gamma R-mediated phagocytosis
SYK; FCGR2B; LIMK2; PRKCB; RPS6KB2; cgr2b; PTPRC; PIK3R5; PPAP2A; PIK3R2
Chronic myeloid leukemia
GRB2; TGFBR2; PIK3CG; SHC2; SHC4; ABL1; CTBP2; TP53; TRP53; MAP2K1

Protein Function

GAB2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB2 itself. We selected most functions GAB2 had, and list some proteins which have the same functions with GAB2. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein ANXA8; PIRT; FAM21C; INPPL1; RAG2; ARAP1; ZFYVE16; NRGN; JPH2; ADAP2
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein RAG2; MYO1G; PHLDA3; KIF16B; DAPP1; TTPA; ANXA8; PLEKHA1; MAPKAP1; SESTD1
Function protein binding
Related Protein XK; MED31; GM885; LAMTOR1; NTS; SPG7; ELF1; PFTK1; DUSP9; MLLT4
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein SHC1; BLNK; GAB2; DOK2; IRS1; PIK3R1; TRAT1; SH2B2; STAP1; FRS2

Interacting Protein

GAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB2.
GRB2; PTPN11

GAB2 Related Articles

Huang, YJ; Frazier, ML; et al. Reverse-Phase Protein Array Analysis to Identify Biomarker Proteins in Human Pancreatic Cancer. DIGESTIVE DISEASES AND SCIENCES 59:968-975(2014).
Quintas-Cardama, A; Qiu, YH; et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. CANCER 118:5283-5292(2012).

GAB2 Related Gene Family

TGF