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Official Full Name GRB2-associated binding protein 2
Background The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their
Synonyms GAB2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Grb2 associated binder 2; KIAA0571; pp100; Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GAB2-4620H Recombinant Human GAB2 Protein, GST-tagged Wheat Germ GST
    Human GAB2-6074HCL Recombinant Human GAB2 293 Cell Lysate HEK293 N/A
    Mouse Gab2-1851M Recombinant Mouse Gab2 protein, His & T7-tagged E.coli His/T7
    Rat GAB2-2439R Recombinant Rat GAB2 Protein Mammalian Cell His

    GAB2 involved in several pathways and played different roles in them. We selected most pathways GAB2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway RASA4; PDGFD; RALB; PAK7; SHOC2; CSF1; FGF3; RASA1; GNG3; FGFR3
    Sphingolipid signaling pathway MAP2K2; TRP53; ASAH2; PPP2R5B; SGPP1; SPTLC1; GNAI1; PPP2R2C; GAB2; SMPD2
    Phospholipase D signaling pathway DGKE; Pdgfa&Pdgfb; RALGDS; GRM4; AVPR2; SYK; SHC1; SHC4; PTPN11; PTK2B
    Osteoclast differentiation LILRA5; PPP3R2; CYBA; TGFB2; PPP3CA; FCGR3B; PLCG2; FYN; SIRPG; FCGR2A
    Fc epsilon RI signaling pathway MAPK9; IL13; BTK; PLA2G4B; PLCG2; SOS1; MAPK10; LCP2; LAT; MS4A2
    Fc gamma R-mediated phagocytosis FCGR2A; RAC1; AKT1; WASF3; PLA2G4F; SPHK2; PIP5K1C; PTPRC; PIK3CB; FCGR1A
    Chronic myeloid leukemia STAT5B; NFKBIA; RB1; TRP53; MAPK3; PIK3CA; PIK3R3; CBLB; HRAS; ABL1

    GAB2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB2 itself. We selected most functions GAB2 had, and list some proteins which have the same functions with GAB2. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol-3,4,5-trisphosphate binding DAPP1; BTK; KIF16B; CYTH3; JPH2; MYO1G; ADAP2; INPPL1; ARHGAP9; PHLDA3
    phosphatidylinositol-3,4-bisphosphate binding MYO1G; PLEK; ZFYVE1; NCF1; FAM21C; AKT1; D6WSU116E; ADAP2; ARAP3; DAPP1
    protein binding ALOX5AP; APLP1; MID2; FBXO34; GFPT2; IL7; SMARCC2; JAKMIP2; RSAD2; PRDM4
    transmembrane receptor protein tyrosine kinase adaptor activity SH2B2; TRAT1; BLNK; IRS1; SHC1; DOK2; PIK3R1; GAB2; FRS2; STAP1

    GAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB2.

    GRB2; PTPN11

    Huang, YJ; Frazier, ML; et al. Reverse-Phase Protein Array Analysis to Identify Biomarker Proteins in Human Pancreatic Cancer. DIGESTIVE DISEASES AND SCIENCES 59:968-975(2014).
    Quintas-Cardama, A; Qiu, YH; et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. CANCER 118:5283-5292(2012).


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