GCK Protein, glucokinase (hexokinase 4)


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Official Full Name glucokinase (hexokinase 4)
Background Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Synonyms GCK; glucokinase (hexokinase 4); GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3; glucokinase; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GCK-005H Recombinant Human GCK Protein, His-tagged E.coli His
    Mouse Gck-245M Recombinant Mouse Gck Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human GCK-196H Recombinant Human Glucokinase (Hexokinase 4), His-tagged E.coli His
    Human GCK-199H Recombinant Human GCK, His-tagged E.coli His
    Human GCK-200H Recombinant Human GCK, His-tagged E.coli His
    Human GCK-28593TH Recombinant Human GCK E.coli N/A
    Human GCK-29572TH Recombinant Human GCK, His-tagged E.coli His
    Human GCK-323H Recombinant Human Glucokinase (Hexokinase 4), GST-tagged, Active Sf9 Insect Cell GST
    Human GCK-328H Recombinant Human Glucokinase (Hexokinase 4) E.coli N/A
    Human GCK-4798H Recombinant Human GCK Protein, GST-tagged Wheat Germ GST
    Human GCK-5985HCL Recombinant Human GCK 293 Cell Lysate HEK293 N/A
    Human GCK-658H Recombinant Human GCK Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GCK-887H Recombinant Human GCK, None tagged E.coli N/A
    Mouse GCK-6265M Recombinant Mouse GCK Protein Mammalian Cell His
    Mouse Gck-748M Recombinant Mouse Gck protein, His & T7-tagged E.coli His/T7
    Rat Gck-749R Recombinant Rat Gck protein, His & GST-tagged E.coli His/GST
    Zebrafish GCK-4354Z Recombinant Zebrafish GCK Mammalian Cell His

    GCK involved in several pathways and played different roles in them. We selected most pathways GCK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    GCK has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GCK itself. We selected most functions GCK had, and list some proteins which have the same functions with GCK. You can find most of the proteins on our site.

    Function Related Protein

    GCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCK here. Most of them are supplied by our site. Hope this information will be useful for your research of GCK.

    PFKFB1; GCKR; Pfkfb3; Pfkfb1; Gckr

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