|Official Full Name||glucokinase (hexokinase 4)|
|Background||Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]|
|Synonyms||GCK; glucokinase (hexokinase 4); GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3; glucokinase; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase;|
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GCK involved in several pathways and played different roles in them. We selected most pathways GCK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
GCK has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GCK itself. We selected most functions GCK had, and list some proteins which have the same functions with GCK. You can find most of the proteins on our site.
GCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCK here. Most of them are supplied by our site. Hope this information will be useful for your research of GCK.
PFKFB1; GCKR; Pfkfb3; Pfkfb1; Gckr