gfra4
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  • Official Full Name
  • GDNF family receptor alpha 4
  • Background
  • The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • GFRA4; GDNF family receptor alpha 4; GDNF family receptor alpha-4; persephin receptor; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107
Cat.#:GFRA4-715HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GFRA4 Protein, His-tagged
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Cat.#:GFRA4-2515RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GFRA4 Protein
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Cat.#:GFRA4-6549CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GFRA4
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Cat.#:GFRA4-5951HCLTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human GFRA4 Cell Lysate, transcript variant 1
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Cat.#:GFRA4-5952HCLTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human GFRA4 Cell Lysate, transcript variant 2
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Involved Pathway

GFRA4 involved in several pathways and played different roles in them. We selected most pathways GFRA4 participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
RND1; COL4A5; EFNB3; ABLIM2; KIF4A; EPHA5; DPYSL2; EPHB1; RASA1; FRS2B
Developmental Biology
RHOAE; JAK3; HIF3A; MYOD1; INSM1B; MYOG; CAP1; DPYSL2B; MED10; CD24
NCAM signaling for neurite out-growth
COL9A1B; COL9A1A; GFRA2; GDNF; GFRA4; GFRA1; PSPN; NRTN; ST8SIA2
NCAM1 interactions
GDNF; NRTN; COL9A1B; GFRA2; GFRA4; GFRA1; COL9A1A; PSPN

Protein Function

GFRA4 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA4 itself. We selected most functions GFRA4 had, and list some proteins which have the same functions with GFRA4. You can find most of the proteins on our site.
Function
Related Protein
Function glial cell-derived neurotrophic factor receptor activity
Related Protein GFRA1; GFRA4; GFRA2

GFRA4 Related Articles

Liu, W; Rask-Andersen, H; et al. Immunohistological analysis of neurturin and its receptors in human cochlea. AURIS NASUS LARYNX 41:172-178(2014).
Gassei, K; Ehmcke, J; et al. Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men. JOURNAL OF MEDICAL PRIMATOLOGY 39:83-91(2010).

GFRA4 Related Gene Family

TGF