gli3
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  • Official Full Name
  • GLI family zinc finger 3
  • Background
  • This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
  • Synonyms
  • GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA
Cat.#:GLI3-4956HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLI3 Protein, GST-tagged
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Cat.#:GLI3-1707HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI3 protein, His & T7-tagged
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Cat.#:Gli3-1708MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gli3 protein, His & T7-tagged
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Cat.#:GLI3-4675CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLI3
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Cat.#:GLI3-11747ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLI3
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Cat.#:GLI3-5904HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLI3 293 Cell Lysate
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Involved Pathway

GLI3 involved in several pathways and played different roles in them. We selected most pathways GLI3 participated on our site, such as cAMP signaling pathway, Hedgehog signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
GNAI1; PPP1R12A; NPY; ATP1A3; BAD; ACOX1; CNGA3; Adcy4; PPP1CA; HTR6
Hedgehog signaling pathway
PTCH1; WNT2BA; WNT11R; WNT2B; SHHA; LRP2A; STK36; WNT10B; CSNK1DA; WNT7A
Pathways in cancer
STAT1; NRAS; MMP1A; HIF1A; FZD3; STAT3; IL-8; GNA12; TRAF1; DAPK1
Basal cell carcinoma
WNT2; FZD3; BMP4; FZD5; SUFU; WNT9A; GLI2; GSK3B; Fzd4; DVL1

Protein Function

GLI3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, beta-catenin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI3 itself. We selected most functions GLI3 had, and list some proteins which have the same functions with GLI3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RFX4; NRF1; MEF2B; BSX; NFIB; SRF; KLF17; CREB3L2; SFPI1; MYB
Function beta-catenin binding
Related Protein CTNNA3; BCL9; C; PTBP3; NUMB; PXN; CDH2; CDH1; PARK2; DACT3
Function chromatin binding
Related Protein MPO; DMRT1; BRD3; ELK4; AIRE; SSBP1; ERCC6; NEUROD1; ASCL1; ING5
Function histone acetyltransferase binding
Related Protein TAF7; ZBTB7A; SIRT2; EGR1; KAT2B; CREB1; CITED2; SP1; PCNA; HIF1A
Function histone deacetylase binding
Related Protein TRAF6; TAL1; CEBPB; KAT2B; NUDT21; MAPK8; NKX3-1; PRDM1; ANKRA2; RELA
Function metal ion binding
Related Protein NME7; KIN; CACNA2D1; ZNF354A; PRKCI; GATA5; PHYH; ZBTB4; PFKMB; TRIM105
Function protein binding
Related Protein CEP55; ARMC8; EHMT2; CARM1; MCRS1; RMI1; C11orf54; MGST3; PEBP1; Rhox5
Function transcription factor activity, sequence-specific DNA binding
Related Protein EGR4; BRD8; BLZF1; TEF; HSF4; DMRT3; RNF4; E2F6; FEV; HOXC4A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein YBX1; BATF; FOS; OTX1; TCF12; GCM1; ESR1; NFYC; ARNT2; ATF4

Interacting Protein

GLI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI3.
SUFU; STK36; Zic1; Zic2; SMAD1; Zic3; Pias1; q8cln9_yerpe; Sufu; YWHAE