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Official Full Name GLI family zinc finger 3
Background This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
Synonyms GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GLI3-1707H Recombinant Human GLI3 protein, His & T7-tagged E.coli His/T7
    Human GLI3-4956H Recombinant Human GLI3 Protein, GST-tagged Wheat Germ GST
    Human GLI3-5904HCL Recombinant Human GLI3 293 Cell Lysate HEK293 N/A
    Mouse Gli3-1708M Recombinant Mouse Gli3 protein, His & T7-tagged E.coli His/T7
    Chicken GLI3-4675C Recombinant Chicken GLI3 Mammalian Cell His
    Zebrafish GLI3-11747Z Recombinant Zebrafish GLI3 Mammalian Cell His

    GLI3 involved in several pathways and played different roles in them. We selected most pathways GLI3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway GRIA3; MAP2K2; RAC2; ATP2B1; CALM4; F2R; ROCK2; PRKACA; PDE3A; GLI3
    Hedgehog signaling pathway IHHA; WNT11; WNT5B; WNT5A; DYRK1A; LRP2A; GAS1B; GSK3B; WNT9B; SKI
    Pathways in cancer WNT3; RAC2; FZD2; SMAD4; FGF4; MMP9; Adcy4; BIRC3; PTCH1; RBX1
    Basal cell carcinoma FZD7; WNT11; FZD10; WNT7A; WNT4; WNT2; DVL2; FZD5; GLI2; LEF1

    GLI3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI3 itself. We selected most functions GLI3 had, and list some proteins which have the same functions with GLI3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding BATF; FOXA2; GRHL1; NEUROD6; HOXA5; FIGLA; FLI1; NR2C1; RBPJB; FOSL1
    beta-catenin binding TCF7L1A; LEF1; GSK3B; MED12; NF2; CBY1; Ar; RORA; CTNNA3; LZIC
    chromatin binding ENY2; AIRE; KDM5A; PRIMPOL; WHSC1; RNF168; RAD51; CENPB; C10orf119; SIN3A
    histone acetyltransferase binding TAF7L; EID1; CITED2; TRIP4; MTF1; ETS1; TRIM68; PAX6; PCNA; FOXP3
    histone deacetylase binding GLI3; ZMYND15; SOD3; SKOR2; BCOR; NR2C1; GCM1; PKN1; YWHAB; DDX20
    metal ion binding CYP2P8; PRKCHA; ZNF683; KLF5; EYA4; PVALB3; GNA13; HEPHL1; ITGAX; TGFBR1B
    protein binding SGIP1; NRL; ABLIM1; F3; MT2A; DCTN4; SELPLG; CEP76; PCBP1; SLAMF1
    transcription factor activity, sequence-specific DNA binding HOXB3A; HOXB8; SOX1; SOX11A; CREBL2; HLFB; HOXA2B; HSF5; NFYAL; HER5
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding YBX1; FOXA1; MEIS3; HOXA5; MYOG; ISL1; MESP1; NR1H4; SIX1; ETV6

    GLI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI3.

    SUFU; STK36; Zic1; Zic2; SMAD1; Zic3; Pias1; q8cln9_yerpe; Sufu; YWHAE

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