Recombinant Human GLI3 Protein, GST-tagged

• Cat.No.: GLI3-4956H
• Product Overview: Human GLI3 partial ORF ( NP_000159, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.84 kDa
• AA Sequence: MEAQSHSSTTTEKKKVENSIVKCST RTDVSEKAVASSTTSNEDESPGQTY HRERRNAITMQPQNVQGLSKVSEEP STSSDERASLIKKEIHGSLPHVAEP SVPYRGTVFA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GLI3 GLI family zinc finger 3 [ Homo sapiens ]
• Official Symbol: GLI3
• Synonyms: GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3, glioma associated oncogene family zinc finger 3, Greig cephalopolysyndactyly syndrome, PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; GLI-Kruppel family member GLI3; glioma-associated oncogene family zinc finger 3; PHS; GCPS; PAP-A; GLI3FL; GLI3-190
• Gene ID: 2737
• mRNA Refseq: NM_000168
• Protein Refseq: NP_000159
• MIM: 165240
• UniProt ID: P10071