• Official Full Name
  • grainyhead-like 3 (Drosophila)
  • Background
  • This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms
  • GRHL3; grainyhead-like 3 (Drosophila); TFCP2L4, transcription factor CP2 like 4; grainyhead-like protein 3 homolog; SOM; Drosophila; Grainyhead like 3; Grainyhead like protein 3 homolog; Sister of mammalian grainyhead protein; TFCP2L4; Transcription factor CP2 like 4; OTTHUMP00000003072; OTTHUMP00000003297; OTTHUMP00000003298; OTTHUMP00000234795; transcription factor hSOM1; sister of mammalian grainyhead; sister-of-mammalian grainyhead; transcription factor CP2-like 4
Source (Host):HEK293Species:Human
Product nameRecombinant Human GRHL3 Protein, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRHL3 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRHL3, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRHL3 Protein

Protein Function

GRHL3 has several biochemical functions, for example, chromatin DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL3 itself. We selected most functions GRHL3 had, and list some proteins which have the same functions with GRHL3. You can find most of the proteins on our site.
Related Protein
Function chromatin DNA binding
Related Protein RUVBL2; RELA; MYOG; BCL6; ATOH1; FOXO3; GRHL3; XBP1; EP300; MYOD1
Function protein binding
Related Protein GCNT1; ZSCAN21; C2orf51; KRTAP19-7; CHD2; MRPL11; KLRB1B; BANF1; ASF1B; CCDC148
Function sequence-specific DNA binding
Related Protein ISX; NKX6-1; NLRP3; NKX3.2; PKNOX1.1; DMRT2A; FOXF2; GATA5; NR1H4; LMX1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN14; FOXN3; DLX2; GRHL2A; GPBP1L1; SPI1A; ZNF621; ARNT2; FOXI1; FOXD1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein OVOL2; GATA1; NHLH1; NEUROD2; CSRNP2; ALX4; ETV5; TBX5; SRF; TRPS1

Interacting Protein

GRHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL3.

GRHL3 Related Articles

Pourhoseini, S; Seth, RK; et al. Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis. PLOS ONE 10:-(2015).
Gordon, WM; Zeller, MD; et al. A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia. JOURNAL OF CLINICAL INVESTIGATION 124:5205-5218(2014).