GUCY1A3
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Official Full Name
guanylate cyclase 1, soluble, alpha 3 -
Overview
soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006] -
Synonyms
GUCY1A3;guanylate cyclase 1, soluble, alpha 3;SGC;Gucy1a1;guanylate cyclase soluble subunit alpha-3;GCS-alpha-1;GCS-alpha-3;soluble guanylate cyclase large subunit;Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase);Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GUCY1A3-2478Z | Recombinant Zebrafish GUCY1A3 | Mammalian Cells | Zebrafish | His |
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| GUCY1A3-4489H | Recombinant Human GUCY1A3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GUCY1A3-627H | Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged | Sf9 Cells | Human | His |
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| GUCY1A3-7388M | Recombinant Mouse GUCY1A3 Protein | Mammalian Cells | Mouse | His |
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| GUCY1A3-5677HCL | Recombinant Human GUCY1A3 293 Cell Lysate | HEK293 | Human | Non |
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| GUCY1A3-3345HF | Recombinant Full Length Human GUCY1A3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 690 amino acids |
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| GUCY1A3-4009M | Recombinant Mouse GUCY1A3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GUCY1A3-4009M-B | Recombinant Mouse GUCY1A3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | GNA11,NFATC2,AKT2,PPP3CC,TRPC6,ATP1A3,PRKG1,PPP1CC,VDAC1,MYLK4 |
| Gap junction | GUCY1B3,PDGFA,HRASA,PDGFRA,EGFRA,TUBA8L3,Adcy4,TUBA1L,TUBA1L2,MAP2K1 |
| Renin secretion | PPP3CA,ITPR1,PPP3CC,PLCB2,GNAI2,NPR1,CLCA3,AGTR1A,REN,CLCA1 |
| Vascular smooth muscle contraction | PLA2G4AA,CALM1A,GNA11B,GNA12,PRKACB,PRKG1A,PLA2G2D,PLA2G2F,CALM3B,ROCK2A |
| Purine metabolism | PAPSS2B,PGM2,ADK,POLR2J2,PDE4B,NME5,PDE3A,POLR2J3,APRT,IMPDH1A |
| Oxytocin signaling pathway | SRC,CAMK4,ELK1,NPR2,PLA2G4A,NRAS,PPP1R12A,PIK3CB,ITPR3,CACNB2 |
| Long-term depression | GRID2,PPP2CB,GUCY1B3,ARAF,PPP2R1B,MAPK3,GNAI1,GNA11,PPP1R17,PLA2G4A |
| Circadian entrainment | Adcy4,PER2,CAMK2A,GNAI1,GRIA4,GRIN1,CALM3,PRKCG,PRKACB,NOS1 |
| Platelet activation | LYN,PLA2G4C,FGG,FERMT3,LCP2,NOS3,PIK3CB,PRKCZ,TLN1,FGB |
Protein Function
GUCY1A3 has several biochemical functions, for example, GTP binding,NOT adenylate cyclase activity,guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | MCC,NLGN3A,ITGB3A,XPR1,GRIN1A,NRXN1,IL18RAP,ATRN,SLC20A2,ITGB3B |
| protein heterodimerization activity | ZFP423,TOP2A,TLR1,TCF4,CEBPG,TAF6,TAF9B,THRA,AGTR1,MCL1 |
| GTP binding | GNL1,ERAL1,RHOD,RAB7,RAB3DB,RASL11A,RALBB,GNA11A,RAB7A,SEPT9 |
| NOT adenylate cyclase activity | GUCY2F,NPR1A,NPR1,GUCY1B3,GUCY2C,NPR3,GC3,GC2,NPR2 |
| protein binding | CDR2,GPA33,CYSLTR2,CDK2,FZD6,CSF2RA,TGS1,NDUFS2,RUVBL2,ZNF207 |
| heme binding | SDHD,CYP2C37,CYP2B19,CYP2AD6,EIF2AK1,CYP2AD3,CYP27B1,MFSD7C,CYP3A7,CYP46A1.1 |
| guanylate cyclase activity | GUCY2E,GC3,NPR1,GUCY2F,GUCY2C,GC2,NPR2,NPR1A,GUCY1B3 |
Interacting Protein
GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.
GUCY1B3;gtp;MAPK8;IKBKG
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References
- Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).
- Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).
