GUCY1A3

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GUCY1A3

Official Full Name guanylate cyclase 1, soluble, alpha 3
Background soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
Synonyms GUCY1A3; guanylate cyclase 1, soluble, alpha 3; SGC; Gucy1a1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; soluble guanylate cyclase large subunit; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase);
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GUCY1A3-4489H Recombinant Human GUCY1A3 Protein, GST-tagged Wheat Germ GST
    Human GUCY1A3-5677HCL Recombinant Human GUCY1A3 293 Cell Lysate HEK293 N/A
    Human GUCY1A3-627H Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged Sf9 Insect Cell His
    Mouse GUCY1A3-7388M Recombinant Mouse GUCY1A3 Protein Mammalian Cell His
    Zebrafish GUCY1A3-2478Z Recombinant Zebrafish GUCY1A3 Mammalian Cell His

    GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism PPAT; AMPD3B; NUDT5; AMPD2; IMPDH1B; URAD; ENTPD8; POLR1B; PDE6B; ATIC
    cGMP-PKG signaling pathway INS; CALM1; NPR1; NPR2; PPP3CB; GNAQ; CREB3L3; GNA12; AKT2; GNA11
    Vascular smooth muscle contraction MYL9A; MAPK3; ITPR1; KCNMB4; CALM1; CALM1B; GNA13A; PRKCBB; PRKCG; RHOAA
    Gap junction RAF1B; TJP1; PLCB1; DRD1B; GUCY1A3; TUBA8L2; TUBA8L4; PLCB4; HTR2CL1; TUBA4L
    Platelet activation FERMT3; MAPK11; PRKACA; GNAI1; AKT2; GP1BA; PLCB1; VWF; PTGS1; TBXA2R
    Circadian entrainment NOS1AP; RYR2; KCNJ5; GNG10; FOS; PRKCA; RYR1; ITPR1; CALM1; RPS6KA5
    Long-term depression ITPR3; GNA11; PLCB4; PPP2R1A; MAP2K1; CRHR1; RAF1; GNAZ; HRAS; NOS1
    Oxytocin signaling pathway OXT; RGS2; PPP1CC; PRKAG2; PLCB2; TRPM2; RYR2; PLA2G4D; NPR1; PPP3CB
    Renin secretion PLCB1; ORAI1; GNAI2; CLCA3; REN2; PDE1B; Ren1; GUCY1B3; CALML3; PRKACA
    Salivary secretion CST3; ATP1B4; CST1; ATP1B1; PRH2; ATP2B4; PRKCG; CST4; VAMP2; BEST2

    GUCY1A3 has several biochemical functions, for example, GTP binding, NOT adenylate cyclase activity, guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding EEF1A1L1; RAB7B; RHOC; GNA13A; RTKN; RAB36; SEPT12; GMPPAB; RAB42B; GIMAP2
    NOT adenylate cyclase activity GUCY2C; GUCY2F; NPR1A; GUCY1A3; NPR1; NPR2; GUCY1B3; NPR3; GC3; GC2
    guanylate cyclase activity NPR2; GUCY2E; GUCY1A3; GUCY2C; GC2; GUCY2F; NPR1; NPR1A; GC3; GUCY1B3
    heme binding CYP2D10; CYP27A1; STC2; CYP46A1.3; CYP4V8; CYGB; CYP19A1A; NR1D1; DUOX2; PTGS2
    protein binding RPL7A; NDUFS7; PSEN1; STOM; DNM3; CCDC117; BDKRB2; CX3CL1; RP2; CHMP4C
    protein heterodimerization activity CABYR; FLOT2; SFRP5; AGTR1; CAV1; DDX1; HIST1H2A9; CAV2; ABCG8; PKNOX1
    receptor activity V1RA8; ABP1; LYVE1; SELS; KIR2DL1; FAS; LILRA3; NLGN2A; NLGN2B; NPY2R

    GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.

    GUCY1B3; gtp; MAPK8; IKBKG

    Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).
    Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).

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