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GUCY1A3

  • Official Full Name

    guanylate cyclase 1, soluble, alpha 3

  • Overview

    soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
  • Synonyms

    GUCY1A3; guanylate cyclase 1, soluble, alpha 3; SGC; Gucy1a1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; soluble guanylate cyclase large subunit; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GUCY1A3-4489H Recombinant Human GUCY1A3 Protein, GST-tagged Wheat Germ GST
Human GUCY1A3-627H Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged Sf9 Insect Cell His
Human GUCY1A3-5677HCL Recombinant Human GUCY1A3 293 Cell Lysate HEK293 N/A
Human GUCY1A3-3345HF Recombinant Full Length Human GUCY1A3 Protein, GST-tagged In Vitro Cell Free System GST 690 amino acids
Mouse GUCY1A3-7388M Recombinant Mouse GUCY1A3 Protein Mammalian Cell His
Mouse GUCY1A3-4009M Recombinant Mouse GUCY1A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GUCY1A3-4009M-B Recombinant Mouse GUCY1A3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GUCY1A3-2478Z Recombinant Zebrafish GUCY1A3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GUCY1A3 Related Articles

GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismNPR1A;POLE4;AK5;PNP5A;ENTPD2;NME2B.2;NME3;POLE3;GUCY2E
cGMP-PKG signaling pathwayTRPC6;SRF;PPP1CC;PPP3R2;PPP3CB;PPP1CB;CALM4;IRS4;RAF1
Vascular smooth muscle contractionROCK2A;GNA12;CALM3;ARHGEF12;ITPR1;PRKCB;GNAS;MYL6B;PLA2G1B
Gap junctionPDGFB;PDGFD;PLCB3;MAP3K2;GNAI3;TUBB5;CDK1;TUBA8L4;TUBA1L
Platelet activationVWF;PPP1CB;COL24A1;ORAI1;PLA2G4F;MYLK;FYN;PLCB2;MYL12A
Circadian entrainmentMTNR1A;GNAI3;ITPR1;NOS1AP;Adcy4;AKR1C1;PER1;CACNA1G;PLCB3
Long-term depressionGNAI2;IGF1R;GNAS;PPP2CA;BRAF;GNAQ;GRM1;ITPR3;GRIA1
Oxytocin signaling pathwayCAMK2B;ITPR1;CALML3;CAMK4;MYLK3;PPP3CC;CAMKK2;CACNB4;NFATC4
Renin secretionCLCA1;PRKACG;PRKG2;PTGER2;CALML3;PDE1C;PDE1A;GNAQ;REN
Salivary secretionTRPV6;AMY1A;DMBT1;PLCB1;FXYD2;PRKACG;BEST2;ITPR1;AMY1B

GUCY1A3 has several biochemical functions, for example, GTP binding, NOT adenylate cyclase activity, guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.

Function Related Protein
GTP bindingARL4AB;DNM2B;RAB32;RHOB;RAC3B;RAB3D;GNA15;RAC1;DIRAS3
NOT adenylate cyclase activityGUCY1B3;GUCY2F;NPR3;NPR1;NPR2;GUCY1A3;GC2;NPR1A;GUCY2C
guanylate cyclase activityGUCY1B3;GUCY2C;GC2;GC3;NPR2;GUCY2E;NPR1A;GUCY2F;NPR1
heme bindingJAK2;HBE1;CYP2C54;DGCR8;CYP4A11;CYP1C2;CYP4B1;CYP2A12;SRC
protein bindingANG;OSBPL7;TOP3A;RIPPLY2;JAK2;PIK3R2;ARVCF;CSE1L;HIST1H2AK
protein heterodimerization activityHIST1H2B8;EXT1;PDSS2;JDP2;HIST1H4G;TOP2A;SOX17;FLOT2;MYOG
receptor activityANTXRL;RTN4RL1;PAQR5;FPR3;PVRL3B;CD160;RNF139;PAQR5B;PVR

GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.

GUCY1B3; gtp; MAPK8; IKBKG

Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).
Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).
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