gucy1b3
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  • Official Full Name
  • Guanylate cyclase 1, soluble, beta 3
  • Background
  • Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
  • Synonyms
  • GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1; GUCY1B3; GCS-beta-1; GCS-beta-3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit
Cat.#:GUCY1B3-4491HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GUCY1B3 Protein, GST-tagged
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Cat.#:GUCY1B3-13619HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUCY1B3, His-tagged
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Cat.#:GUCY1B3-2755RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GUCY1B3 Protein
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Cat.#:GUCY1B3-2019RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GUCY1B3 Protein, His-tagged
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Cat.#:GUCY1B3-8100ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GUCY1B3
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Cat.#:GUCY1B3-5676HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GUCY1B3 293 Cell Lysate
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Involved Pathway

GUCY1B3 involved in several pathways and played different roles in them. We selected most pathways GUCY1B3 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1B3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GDA; NME2; ITPA; POLR2C; ADCY1A; PFAS; PDE4A; DGUOK; PKM2; PKMA
cGMP-PKG signaling pathway
MEF2D; IRS2; GTF2IRD1; ATP1B3; RAF1; INSR; TRPC6; NFATC3; INS; PDE3A
Vascular smooth muscle contraction
ARHGEF1; PLA2G2D; MYL9B; GNA11A; PLCB2; CALM2; CALM2A; PRKCBB; RHOAD; CALM
Gap junction
TUBA8L4; HTR2A; PRKACAB; GRB2; CX35B; TUBA8L2; TUBA1C; ADCY1B; TUBA3B; TUBA1A
Platelet activation
SRC; BTK; MYLK4; AKT2; ARHGAP35; GP9; TBXAS1; PRKACB; MYL12A; PLA2G4A
Circadian entrainment
CALM1; GNG4; PRKACB; MTNR1A; NOS1; PLCB2; MAPK3; PLCB4; GNG5; CAMK2G
Long-term depression
GRID2; GUCY1A3; PPP2CB; GNAS; PRKG2; IGF1; PRKCA; PLCB2; GNAI2; IGF1R
Oxytocin signaling pathway
CACNG8; CAMKK1; PLCB3; CACNA2D3; RAF1; MAP2K1; CAMK1; PIK3CB; PLA2G4D; PLA2G4C
Renin secretion
CALM3; CLCA2; ITPR1; CLCA5; PRKG2; PLCB1; PPP3CA; CALML5; REN2; AGTR1A
Salivary secretion
PRH2; PLCB1; PRKCB; GNAS; DMBT1; CAP18; PLCB3; PRB1; ATP1B1; ITPR3

Protein Function

GUCY1B3 has several biochemical functions, for example, GTP binding, NOT adenylate cyclase activity, guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1B3 itself. We selected most functions GUCY1B3 had, and list some proteins which have the same functions with GUCY1B3. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein GFM2; GIMAP1; SEPT8B; DNM1L; ANXA6; EEF2B; EHD2; OPA1; GNL1; TUBB2
Function NOT adenylate cyclase activity
Related Protein NPR2; GUCY2F; NPR3; NPR1; GC2; GUCY1A3; GC3; GUCY2C; NPR1A; GUCY1B3
Function guanylate cyclase activity
Related Protein GC2; NPR1A; NPR2; GUCY2C; GUCY1A3; NPR1; GUCY1B3; GUCY2F; GC3; GUCY2E
Function heme binding
Related Protein IRGM1; NOX5; CYGB1; ABCB6; CYP2A4; CYP4Z1; XGB; TDO2B; CYP3C4; CYP2C50
Function metal ion binding
Related Protein ZDHHC5A; ZFP653; ILKAP; ZNF143; SMYD2A; AARS; SP4; ACLY; FAM96A; EPX
Function protein binding
Related Protein TFDP1; CD200R4; DYNLRB1; CXorf40A; WASF2; RUNDC3A; THOC4; POU2AF1; NTF4; ADI1
Function receptor activity
Related Protein MED13; CD4; GUCY1B3; CADM4; PROCR; CD86; CD33; GFRA1A; PVRL1B; CD200R2

Interacting Protein

GUCY1B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1B3.
GUCY1A3; LIN7A