Recombinant Human GUCY1B3, His-tagged

• Cat.No.: GUCY1B3-13619H
• Product Overview: Recombinant Human GUCY1B3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 282-619a.a.
• Description: Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GUCY1B3 guanylate cyclase 1, soluble, beta 3 [ Homo sapiens ]
• Official Symbol: GUCY1B3
• Synonyms: GUCY1B3; guanylate cyclase 1, soluble, beta 3; GUC1B3; guanylate cyclase soluble subunit beta-1; GC S beta 1; GC SB3; GCS-beta-1; GCS-beta-3; soluble guanylate cyclase small subunit; guanylate cyclase soluble subunit beta-3; GUCB3; GC-SB3; GUCSB3; GUCY1B1; GC-S-beta-1
• Gene ID: 2983
• mRNA Refseq: NM_000857
• Protein Refseq: NP_000848
• MIM: 139397
• UniProt ID: Q02153
• Chromosome Location: 4q31.3-q33
• Pathway: Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Hemostasis, organism-specific biosystem; Long-term depression, organism-specific biosystem; Long-term depression, conserved biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem
• Function: GTP binding; Hsp90 protein binding; guanylate cyclase activity; heme binding; ion binding; metal ion binding; nucleotide binding; protein heterodimerization activity; receptor activity