FGFR1
-
Official Full Name
fibroblast growth factor receptor 1
-
Overview
Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. -
Synonyms
FLG; FGFR1; fibroblast growth factor receptor 1; CEK; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; H2; H3; H4; H5; Basic fibroblast growth factor receptor 1; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Heparin binding growth factor receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Cynomolgus Monkey
- Gallus gallus (Chicken)
- Human
- Human
- Monkey
- Mouse
- Rat
- Rhesus
- Rhesus Macaque
- Xenopus laevis (African clawed frog)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human cells
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- SF9 insect cells
- Wheat Germ
- Yeast
- C
- hFc
- His
- DDK|His
- Fc
- Fc|His
- His(C
- ter)
- Flag
- GST
- GST|His
- his
- His (Fc)
- Avi
- His|GST
- His|S
- His|T7
- sumostar
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Strep
- T7|His
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- FGFR1 Related Articles
- FGFR1 Related Gene Family
- FGFR1 Related Research Area
- FGFR1 Related Signal Pathway
What is fgfr1 protein?
FGFR1 protein stands for Fibroblast Growth Factor Receptor 1. It is a transmembrane receptor tyrosine kinase that is integral to many important biological processes:FGFR1 helps mediate the effects of fibroblast growth factors (FGFs), which are involved in processes like embryonic development, cell differentiation, cell proliferation, tumor growth, and angiogenesis.When FGFs bind to FGFR1, it causes FGFR1 to dimerize and autophosphorylate its cytoplasmic tyrosine kinase domains.This leads to activation of downstream signaling cascades like Ras-MAPK, PI3K-Akt, and PLCγ pathways.
FGFR1 is expressed in many tissues including epithelial, neuronal, endothelial cells during development and tumorigenesis.Gain-of-function mutations in FGFR1 can cause diseases by overactivating downstream signaling. Loss of function mutations also lead to diseases.FGFR1 play essential roles in development of tissues like bone, brain, lungs. It also contributes to wound healing, regeneration and various cancers when dysregulated.FGFR1 is a key cell surface receptor that mediates many critical FGF-induced biological functions through activation of intracellular signaling pathways upon ligand binding.
What is the function of fgfr1 protein?
Signal transduction: FGFR1 acts as a receptor for fibroblast growth factors (FGFs) on the cell surface. Binding of FGF ligands causes FGFR1 dimerization and autophosphorylation of its tyrosine kinase domains. This leads to activation of intracellular signaling cascades like Ras-MAPK, PI3K-Akt, PLCγ pathways.
Cell proliferation: FGFR1 signaling promotes proliferation of many cell types during development and tissue repair. It plays a role in regulating cell cycle progression, mitosis, and is crucial for growth and survival.
Embryonic development: FGFR1 signaling controls key processes like angiogenesis, limb development, bone formation, organogenesis etc. Important for development of tissues like lung, brain, bone during embryonic morphogenesis.
Fgfr1 related signaling pathway
RAS-MAPK pathway: Binding of FGF ligands leads to autophosphorylation and recruitment of FGFR substrate 2 (FRS2). This activates RAS, RAF, MEK and ERK kinases inducing gene expression changes influencing proliferation, differentiation and survival.
PI3K-Akt pathway: FRS2 also recruits and activates PI3K, leading to phosphorylation and activation of Akt. This pathway regulates cell growth, survival and metabolism.
PLCγ pathway: PLCγ is phosphorylated by FGFR1 inducing downstream PKC and calcium signaling regulating various cellular responses.
Fgfr1 Related Diseases
- Kallmann Syndrome: Genetic defect in FGFR1 causes hypogonadotropic hypogonadism and anosmia.
- Pfeiffer Syndrome: Dominant FGFR1/FGFR2 mutations lead to craniosynostosis, limb/digital anomalies.
- Bladder cancer: FGFR3-TACC3 gene fusions activate FGFR1 signaling driving invasive phenotypes.
- Cancer therapeutic target: Inhibitors targeting FGFR1 signaling show promise in clinical trials for advanced cancers dependent on FGFR activation.
- Angiogenesis modulator: Agents modulating FGFR1 activity influence neovascularization, have scope in treating ischemic diseases and cancer anti-angiogenic strategies.
Biomedical Application of fgfr1 Protein
- Cancer therapeutic target: Inhibitors targeting FGFR1 signaling show promise in clinical trials for advanced cancers dependent on FGFR activation.
- Biomarker for cancer diagnosis: FGFR1 amplification, mutation, expression status used to classify cancer subtypes and guide targeted therapies.
- Tissue regeneration: FGFR1 plays roles in development; enhancing its signaling may aid wound healing, organ reconstruction in regenerative medicine.
- Tissue regeneration: FGFR1 plays roles in development; enhancing its signaling may aid wound healing, organ reconstruction in regenerative medicine.
High Purity
Fig1. SDS-PAGE (FGFR1-18H)
High Bioactivity & Detection Sensitivity
Fig2. Immobilized humen FGF10 (10573-HNAE) at 10 μg/ml (100 μl/well) can bind Rhesus FGFR1-Fc with a linear range of 31.25-2000 ng/mL.2. Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.1-0.6 ng/Ml
(Cheng-Hsiang Kuo, 2015)
Fig3. rTMD23 proteins interact with syndecan-4 and FGFR1. rTMD23 pull-down assay. The pull-down complex was analysed by western blot with antibodies against FGFR1, syndecan-4, and α-tubulin. (A) Pull-down assay in HUVECs. (B) Pull-down assay in FGFR1-expressing HEK293 cells.
Fig4. rTMD23 enhances the phosphorylation of FGFR1. After serum-deprived starvation, HUVECs or HEK293 cells were stimulated with various rTMD23 proteins for the indicated time. Cell lysates were analysed by western blot with specific antibodies against phosphorylated FGFR1-Y653/654, FGFR1, and α-tubulin. (A) rTMD23 enhances the phosphorylation of FGFR1 in HUVECs in a dose-dependent manner. (B) The PD173074 compound suppresses the activation of FGFR1 in FGFR1-expressing HEK293 cells.
FGFR1 involved in several pathways and played different roles in them. We selected most pathways FGFR1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
MAPK signaling pathway | CDC25B;PRKACG;FGF16;STMN1;MAPK8B;PPP3CCB;GADD45BA;AKT3A;ZAK |
Ras signaling pathway | GNG13;PRKCA;KRAS;AKT1;MAP2K2;PRKACB;NF1;ETS2;NFKB1 |
Rap signaling pathway | RRAS;LPAR2;PDGFRB;PIK3CG;PFN3;PARD3;PRKCG;AKT1;FGF13 |
PIK-Akt signaling pathway | COL4A1;FGF16;PPP2R2C;GNG12;TLR2;FGF22;ITGB7;GH2;BRCA1 |
Adherens junction | WASF2;ACTB1;CDH1;VCL;IGF1R;BAIAP2A;NLK1;RAC3B;EP300 |
Signaling pathways regulating pluripotency of stem cells | PCGF6;AKT1;DLX5;ZIC3;WNT10B;GSK3B;WNT6;MAPK1;BMI1 |
Regulation of actin cytoskeleton | MYL12.1;ACTG1;FGF8;RAC1B;ACTN3B;RAC3;ACTB1;RAC3B;ITGA8 |
Pathways in cancer | HSP90B1;Kitl;TCEB1;NTRK1;MAPK1;WNT9B;IKBKG;STAT5A;APC |
Proteoglycans in cancer | PIK3R1;NUDT16L1;PTK2;MSN;ACTG1;IL12B;SMAD2;ITPR3;ARAF |
Prostate cancer | RB1;IKBKG;NFKB1;RELA;PDGFC;HRAS;SMARCA4;SPRY1;HSP90B1 |
Melanoma | FGF20;PIK3CB;PIK3CD;ARAF;FGF16;NRAS;FGF22;FGF4;HGF |
Central carbon metabolism in cancer | PIK3R2;FGFR1;PIK3R1;SLC2A1;SLC1A5;MAPK1;FGFR3;NRAS;SIRT3 |
FGFR1 has several biochemical functions, for example, ATP binding, cell adhesion molecule binding, fibroblast growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1 itself. We selected most functions FGFR1 had, and list some proteins which have the same functions with FGFR1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | TLK1A;SUCLA2;TBK1;MCCC2;FAM20C;YME1L1;SCYL2;CDK10;CDC42BPA |
cell adhesion molecule binding | GRIN2A;Fert2;POSTN;PVRL1;LILRB2;ADAM8;FGG;SMAGP;PVRL2 |
fibroblast growth factor binding | FGFR4;FGFR3;RPS19;FGFRL1;CXCL13;Api5;FGFBP1;RPS2;KLB |
fibroblast growth factor-activated receptor activity | FGFR4;FGFR3;FGFR1B;FGFR1;FGFR1A;FGFRL1;FGFR2 |
glycoprotein binding | STX1A;EDEM1;FBXO2;LDLR;RASA1;ITGB2;IDE;THBS1;SERPINA1A |
heparin binding | HSD17B12;PLA2G2D;SERPIND1;LTF;FBLN7;CECR1;TENM1;WISP1B;AAMP |
identical protein binding | S100A4;COL1A1;DCTPP1;HAND1;DNMT3A;CXADR;BCL2L1;SOX10;PUF60 |
protein binding | ATP5F1;MBL2;C12orf68;MESDC1;PRKRIR;RGS16;ZFAND2B;LRP1;TBK1 |
protein complex binding | GIT1;PTK2B;PPARA;C8B;EP300;KIF11;SKIL;RPAIN;TWF1 |
protein homodimerization activity | OXA1L;MYO7A;PDK2;PVRL4;CEBPA;NR4A3;ERP29;ASNSD1;HINT2 |
protein tyrosine kinase activity | FGFR1B;FGFR1;PTK2AB;SRMS;EPHB2B;CAMKK2;LTK;BCR;INSRA |
FGFR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1.
PLCG1; HTR1A; FGF2
- Q&As
- Reviews
Q&As (5)
Ask a questionDEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.
Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.
While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.
DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.
DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.
Customer Reviews (3)
Write a reviewFGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.
When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.
The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.
Ask a Question for All FGFR1 Products
Required fields are marked with *
My Review for All FGFR1 Products
Required fields are marked with *