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HCN2

  • Official Full Name

    hyperpolarization activated cyclic nucleotide-gated potassium channel 2

  • Overview

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.
  • Synonyms

    HCN2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCN2-1181HFL Recombinant Human HCN2 protein, His&Flag-tagged HEK293 His&Flag 1-889 aa
Mouse HCN2-7520M Recombinant Mouse HCN2 Protein Mammalian Cell His
Mouse HCN2-4083M Recombinant Mouse HCN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HCN2-4083M-B Recombinant Mouse HCN2 Protein Pre-coupled Magnetic Beads HEK293
Rat HCN2-2807R Recombinant Rat HCN2 Protein Mammalian Cell His
Rat HCN2-2462R-B Recombinant Rat HCN2 Protein Pre-coupled Magnetic Beads HEK293
Rat HCN2-2462R Recombinant Rat HCN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HCN2 Related Articles

HCN2 involved in several pathways and played different roles in them. We selected most pathways HCN2 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayPLD2;PPP1CC;CREB3L3;BAD;CALM1;CAMK4;RHOA;GRIN2B;CREB3L2

HCN2 has several biochemical functions, for example, cAMP binding, identical protein binding, intracellular cAMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCN2 itself. We selected most functions HCN2 had, and list some proteins which have the same functions with HCN2. You can find most of the proteins on our site.

Function Related Protein
cAMP bindingRAPGEF4;PDE11A;PRKAR2A;PDE3A;CNGA2;PDE4B;HCN4;CNGA4;PRKAR1B
identical protein bindingVWA2;PTPRM;RBM10;HAND2;IAPP;VAMP2;BNIPL;CLDN1;DAPK3
intracellular cAMP activated cation channel activityCNGA3;HCN2;CNGA4;CNGA5;HCN4;CNGA1
voltage-gated potassium channel activityKCNC1B;KCNH6A;KCNH5A;KCNA2;KCNA1;KCNC3A;KCNH6;KCNMA1A;KCNA2B
voltage-gated sodium channel activitySCN3B;SCN9A;SCN4AB;SCN4A;SCN1LAB;SCN12AA;HCN4;SCN1A;SCN3A

HCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCN2.

Riesen, SC; Schober, KE; et al. Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy. SCHWEIZER ARCHIV FUR TIERHEILKUNDE 155:143-147(2013).
Yang, S; Xiong, CJ; et al. The distribution of HCN2-positive cells in the gastrointestinal tract of mice. JOURNAL OF ANATOMY 221:303-310(2012).
  • Q&As
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