HDAC1 Protein, histone deacetylase 1

HDAC1

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HDAC1

Official Full Name histone deacetylase 1
Background Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Synonyms HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • His/FLAG
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC1-45H Recombinant Human HDAC1 Protein, His/FLAG-tagged Insect Cell His/FLAG
    Human HDAC1-549H Recombinant Human HDAC1 Protein (1-482 aa), His-SUMO-tagged E.coli His/SUMO
    Human HDAC1-1339H Recombinant Human HDAC1, His-tagged Insect Cell His
    Human HDAC1-1353H Recombinant Human HDAC1 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC1-13703H Recombinant Human HDAC1, GST-tagged E.coli GST
    Human HDAC1-1587H Recombinant Human Histone Deacetylase 1, GST-tagged Sf9 Insect Cell GST
    Human HDAC1-27260TH Recombinant Human HDAC1 Insect Cell N/A
    Human HDAC1-29190TH Recombinant Human HDAC1 Insect Cell Flag/His
    Human HDAC1-374H Recombinant Human Histone Deacetylase 1, His-FLAG Tagged Sf9 Insect Cell His/Flag
    Human HDAC1-392H Recombinant Human Histone Deacetylase 1, His-tagged Insect Cell His
    Human HDAC1-4638H Recombinant Human HDAC1 Protein, GST-tagged Wheat Germ GST
    Human HDAC1-527H Recombinant Human HDAC1 Mammalian Cell His
    Human HDAC1-5608HCL Recombinant Human HDAC1 293 Cell Lysate HEK293 N/A
    Human HDAC1-8331H Recombinant Human HDAC1, His tagged Hi-5 Insect Cell His
    Human HDAC1-91H Recombinant Human HDAC1 Protein, FLAG/His-tagged Insect Cell Flag/His
    Mouse HDAC1-7526M Recombinant Mouse HDAC1 Protein Mammalian Cell His
    Rat HDAC1-2814R Recombinant Rat HDAC1 Protein Mammalian Cell His
    Chicken HDAC1-5732C Recombinant Chicken HDAC1 Mammalian Cell His
    Zebrafish HDAC1-9510Z Recombinant Zebrafish HDAC1 Mammalian Cell His
    Kit-1737 HDAC1 Kinetic Assay Kit N/A
    Kit-2283 HDAC1 Immunoprecipitation (IP) & Activity Assay Kit N/A

    HDAC1 involved in several pathways and played different roles in them. We selected most pathways HDAC1 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle H3F3D; AHCTF1; PRKDC; RBX1; CUL1; CEP164; B9D2; LIN54; NDC80; LEMD3
    Notch signaling pathway NOTCH3; HDAC2; PSEN2; MARK2; NOTCH2; APH1B; DLA; YY1; HER15.1; HER12
    Thyroid hormone signaling pathway SLC2A1; ATP1A3; ATP2A2; PRKCA; FOXO1; PLCB1; RXRB; HDAC1; MAPK3; TBC1D4
    Huntingtons disease TRP53; POLR2B; DNAH5; TFAM; COX5A; POLR2E; PLCB4; PPARG; DNAIC2; mt-Atp8
    Amphetamine addiction GRIN2A; SIRT1; SLC18A2; GRIN2D; PPP1CA; CREB5; PRKCG; TH; CREB3; SLC14A2
    Alcoholism GRIN2C; DRD2; MAP2K1; HDAC6; HIST4H4; HDAC1; GNG7; GNB2; HIST1H4G; GM14478
    Epstein-Barr virus infection MAP3K14; RB1; PSMD2; HLA-DQB1; TNFAIP3; MAP2K7; POLR3GL; CD40; PSMC5; TP53
    Pathways in cancer Adcy4; CCDC6; SMO; TGFBR1; BID; TGFB3; MAPK9; TP53; RARB; Shh
    Transcriptional misregulation in cancer H3F3C; FUT8; NCOR1; HOXA11; REL; TP53; NGFR; IGF1R; WNT16; HIST1H3D
    Viral carcinogenesis RAC1; HIST1H2BE; HIST1H4E; HIST1H2BK; GTF2A1; HIST1H2BF; ATP6V0D2; CCND1; CDK1; HIST1H4L
    MicroRNAs in cancer SHC4; MAPK1; CCNG1; CCNE2; TRP53; STAT3; Abcb1b; CDC25B; BCL2L2; HOXD10
    Chronic myeloid leukemia SOS1; SHC1; RB1; CBLC; PIK3CB; IKBKB; CTBP2; CDK6; KRAS; TGFBR2

    HDAC1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC1 itself. We selected most functions HDAC1 had, and list some proteins which have the same functions with HDAC1. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC10; HDAC9; HDAC7A; HDAC8; HDAC2; HDAC9B; HDAC4; HDAC7; HDAC3; HDAC5
    NF-kappaB binding CDKN2A; RNF25; FOXP3; NPM1; AP1S2; EP300; HSPA6; HIF1AN; TAF4B; COMMD6
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding CHD4; SMARCE1; HDAC2; ACTL6A; GATAD2B; MBD3; SMARCC1; HDAC1; SMARCA4; MTA2
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding RBBP4; HDAC1; ACTL6A; SMARCE1; SMARCB1; GATAD2B; MTA2; SMARCA4; SMARCC1; MBD3
    RNA polymerase II repressing transcription factor binding BBS4; TBP; BBS2; PPARA; STAT3; GSC; CHD4; SP1; TCF7L2; HDAC2
    RNA polymerase II transcription corepressor activity N4BP2L2; TBX18; HDGF; TCERG1; SIN3B; SIN3AA; HEYL; TLE1; TBX15; HDAC1
    activating transcription factor binding ATOH8; PPARG; EEF1D; HDAC1; ZFP516; DGKQ; SMAD2; MEF2A; PRDM16; EP300
    core promoter binding NKX3-1; NPAS2; GADD45A; XBP1; GATA1; CRY1; MED1; SFPI1; IFI16; MYOD1
    deacetylase activity SIRT1; NDST4; NDST3; MAPK1IP1L; HDAC1; NDST1; MACROD1; C6orf130; MACROD2; AADAC
    enzyme binding GSTM7; N4BP2L2; ERN1; CCND1; PEX7; GSTM1; RARA; GBP1; BIRC5; TOP2B
    histone deacetylase activity HDAC5; SIRT1; MTA2; HDAC3; HDAC11; HDAC6; NACC2; HDAC7; HDAC9; HDAC8
    histone deacetylase binding MAGEA2B; D7ERTD443E; BRMS1; CAMTA2; SUDS3; HDAC3; SOD3; CRY1; ANKRD1; RUNX2
    contributes_to nucleosomal DNA binding SMARCC2; ACTB; SMARCA4; SMARCB1; HDAC1; RBBP4; SMARCC1; GATAD2B; HDAC2; CHD4
    protein N-terminus binding FEZ1; SCFD1; RBPJ; PDLIM5; ALG2; RPS21; KCNIP1; VWF; EXOC4; TGFB1
    protein binding SOCS3; SOX17; GCG; Pilrb1; MAP2; H3F3A; TBCA; NFS1; FBXO3; SULT2A1
    protein deacetylase activity SIRT1; HDAC5; HDAC4; SIRT2; HDAC1; SIN3A; HDAC9; HDAC3; HDAC10; HDAC2
    repressing transcription factor binding EIF4E; HDAC5; RELA; CTNNB1; HDAC1; CBX5; PRDM5; MAGEA2; HDAC7A; PARK7
    transcription factor activity, sequence-specific DNA binding NR2C2; RARGA; HMGA1A; NKX3; POU6F1; HOXB8; MNX1; SKINT8; HOXB7A; TBX16
    transcription factor binding FOXA1; NKX3; SP100; TFDP1A; HDAC2; RNF19A; TFDP1B; SIRT1; MECP2; SRY
    transcription regulatory region DNA binding KCNA3; BCL11AA; CBX4; TAF7; CREB3L2; NFKB1; TFE3; RCOR1; WNT11; TAF9
    transcription regulatory region sequence-specific DNA binding NR5A2; SOX12; CREB3L3; POU2F1; NKX3; BACH1B; NFE2L3; PITX2; GATA3; GATA1

    HDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC1.

    HDAC2; MTA2; RBBP7

    Kim, JH; Jee, BC; et al. Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men. YONSEI MEDICAL JOURNAL 55:1333-1340(2014).
    Zou, JY; Crews, FT; et al. Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling. PLOS ONE 9:-(2014).

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