hdac1
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  • Official Full Name
  • histone deacetylase 1
  • Background
  • Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1;
Cat.#:HDAC1-4638HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC1 Protein, GST-tagged
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Cat.#:HDAC1-1587HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, GST-tagged
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Cat.#:HDAC1-374HTag:His/Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, His-FLAG Tagged
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Cat.#:HDAC1-1339HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1, His-tagged
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Cat.#:HDAC1-13703HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC1, GST-tagged
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Cat.#:HDAC1-27260THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-29190THTag:Flag/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-527HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-8331HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HDAC1, His tagged
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Cat.#:HDAC1-91HTag:FLAG/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC1 Protein, FLAG/His-tagged
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Cat.#:HDAC1-7526MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC1 Protein
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Cat.#:HDAC1-2814RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDAC1 Protein
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Cat.#:HDAC1-5732CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC1
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Cat.#:HDAC1-9510ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDAC1
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Cat.#:HDAC1-392HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, His-tagged
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Cat.#:HDAC1-1353HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC1 (Active), GST-tagged
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Cat.#:HDAC1-5608HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC1 293 Cell Lysate
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Cat.#:Kit-1737Tag:
Source (Host):Species:
Product nameHDAC1 Kinetic Assay Kit
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Cat.#:Kit-2283Tag:
Source (Host):Species:
Product nameHDAC1 Immunoprecipitation (IP) & Activity Assay Kit
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Involved Pathway

HDAC1 involved in several pathways and played different roles in them. We selected most pathways HDAC1 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
MDM2; YWHABB; STAG2; RAD9A; THRSP; CDKN1BA; NIPBLB; TUBGCP2; TUBG2; CCND3
Notch signaling pathway
NUMBL; DLL3; SNW1; DNER; JAG1A; DTX2; DLL4; TLE3A; DLB; MARK2
Thyroid hormone signaling pathway
MED13; HDAC1; PRKACB; NCOA1; PLCZ1; RHEB; ATP1B2; PLN; PLCB3; ACTG1
Huntingtons disease
COX7A1; SLC25A31; NRF1; NDUFV3; POLR2K; SLC25A6; TRP53; GRM5; NDUFS2; TFAM
Amphetamine addiction
PPP3R2; DRD1A; CALML3; CALML5; CREB3L1; CREB3; CREB3L3; GRIA3; GRIA1; ATF2
Alcoholism
GNB1; H2AFB2; HIST1H4N; HIST1H2AO; ATF4; PPP1CA; GNG4; H2AFY; PPP1CC; H2BFWT
Epstein-Barr virus infection
ICAM1; LYN; FCER2; TP53; GTF2B; HDAC2; RIPK1; NFKBIB; POLR3F; PLCG1
Pathways in cancer
RET; PIK3CB; MSH2; PDGFRA; LAMC1; EGLN1; TRAF2; GNG10; FGF11; VEGFC
Transcriptional misregulation in cancer
MMP3; BMP2K; PML; PFTK1; HIST1H3G; PRCC; MPO; FLI1; HIST1H3C; HDAC1
Viral carcinogenesis
YWHAB; PSMC1; TRADD; PIK3R2; STAT3; HIST1H4E; PRKACG; VAC14; GTF2H3; HIST1H4M
MicroRNAs in cancer
ITGA5; BCL2L2; THBS1; STMN1; FZD3; MAP2K1; Abcb1b; CDC25B; BMI1; TNC
Chronic myeloid leukemia
PIK3R3; SOS1; KRAS; CTBP1; PIK3CA; RB1; TP53; CBLC; SHC1; MAP2K2

Protein Function

HDAC1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC1 itself. We selected most functions HDAC1 had, and list some proteins which have the same functions with HDAC1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC9B; HDAC2; HDAC11; HDAC8; HDAC3; HDAC4; HDAC1; HDAC6; HDAC5; HDAC9
Function NF-kappaB binding
Related Protein FOXP3; ANKRD42; EP300; NFKBID; HIF1AN; ANXA4; FAF1; CDKN2A; HDAC1; BRMS1
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein GATAD2B; SMARCA4; HDAC2; SMARCC2; RBBP4; SMARCB1; ACTL6A; MBD3; MTA2; ACTB
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein SMARCC2; SMARCA4; ACTL6A; MTA2; HDAC1; SMARCE1; SMARCC1; HDAC2; RBBP4; SMARCB1
Function RNA polymerase II repressing transcription factor binding
Related Protein MKKS; RBBP8; GSC; BBS7; BBS2; BBS5; TBX5A; BBS10; MTA1; DMAP1
Function RNA polymerase II transcription corepressor activity
Related Protein TBX18; TXLNB; HEYL; UXT; TFAP2B; ELANE; CTBP1; CITED2; SIN3A; HDGF
Function activating transcription factor binding
Related Protein HDAC7A; PPARG; EEF1D; HDAC4; ATOH8; PSIP1; RELA; MEF2C; MEF2D; ZFP516
Function core promoter binding
Related Protein IFI16; RB1; EP300; SPI1; NPAS2; HNRNPU; SFPI1; CALCOCO1; XBP1; KLF4
Function deacetylase activity
Related Protein AADAC; MACROD1; NDST1; HDAC2; C6orf130; NDST4; MACROD2; SIRT1; NDST3; MAPK1IP1L
Function enzyme binding
Related Protein BCR; PRMT1; CAT; RYR2; CSF3; PUS7; TRIO; CD40; PPP1R3D; ABCD1
Function histone deacetylase activity
Related Protein HDAC1; NACC2; HDAC4; HDAC7; HDAC3; HDAC5; SIRT2; HDAC8; ATXN3L; HDAC9
Function histone deacetylase binding
Related Protein MYOCD; TOP2A; NIPBL; HDAC9; USF1; TFAP4; PKN2; MAPK8; CCND1; MEF2B
Function contributes_to nucleosomal DNA binding
Related Protein MBD3; HDAC2; CHD4; HDAC1; ACTB; RBBP4; SMARCC1; SMARCA4; GATAD2B; ACTL6A
Function protein N-terminus binding
Related Protein STX5A; NCOA3; MECP2; VPS25; ZWINT; PPP1CC; SNCA; MNAT1; GLRX; RBPJ
Function protein binding
Related Protein ZNF167; GNB2L1; RNF5; RASSF1; SIGIRR; SIGLEC8; TCF7L1A; SPOPL; TAGLN; TEC
Function protein deacetylase activity
Related Protein HDAC10; HDAC4; HDAC1; HDAC9; SIRT2; SIN3A; HDAC5; SIRT1; HDAC2; HDAC3
Function repressing transcription factor binding
Related Protein RELA; MYC; HDAC1; PARK7; CBX5; HDAC7A; EIF4E; MAGEA2; NFYB; DDX20
Function transcription factor activity, sequence-specific DNA binding
Related Protein GCM2; RXRA; ZFP746; NR1D1; ZNF16; PRRX2; HOXA6; NR2C2; ZNF726; CSRNP1
Function transcription factor binding
Related Protein POU5F1; GCM1; E2F5; DNAJA3; KAT2A; IFT172; E2F1; PIAS1; RNF4; C1QBP
Function transcription regulatory region DNA binding
Related Protein ZNF217; BCL11AB; SOX7; MSX2; SNCA; IKZF2; CREB3L1; CTNNB1; FOXA3; DDIT3
Function transcription regulatory region sequence-specific DNA binding
Related Protein BACH1B; ZNF658; SOX2; PITX2; SOX11; MEF2AA; PER2; SUV39H1; POU5F1; EGR1

Interacting Protein

HDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC1.
HDAC2; MTA2; RBBP7

HDAC1 Related Articles

Kim, JH; Jee, BC; et al. Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men. YONSEI MEDICAL JOURNAL 55:1333-1340(2014).
Zou, JY; Crews, FT; et al. Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling. PLOS ONE 9:-(2014).