hdac1
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  • Official Full Name
  • histone deacetylase 1
  • Background
  • Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1;
Cat.#:HDAC1-549HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC1 Protein (1-482 aa), His-SUMO-tagged
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Cat.#:HDAC1-4638HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC1 Protein, GST-tagged
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Cat.#:HDAC1-1587HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, GST-tagged
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Cat.#:HDAC1-374HTag:His/Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, His-FLAG Tagged
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Cat.#:HDAC1-1339HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1, His-tagged
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Cat.#:HDAC1-13703HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC1, GST-tagged
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Cat.#:HDAC1-27260THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-29190THTag:Flag/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-527HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HDAC1
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Cat.#:HDAC1-8331HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HDAC1, His tagged
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Cat.#:HDAC1-91HTag:FLAG/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC1 Protein, FLAG/His-tagged
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Cat.#:HDAC1-7526MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC1 Protein
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Cat.#:HDAC1-2814RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDAC1 Protein
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Cat.#:HDAC1-5732CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC1
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Cat.#:HDAC1-9510ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDAC1
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Cat.#:HDAC1-392HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 1, His-tagged
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Cat.#:HDAC1-1353HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC1 (Active), GST-tagged
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Cat.#:HDAC1-5608HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC1 293 Cell Lysate
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Cat.#:Kit-1737Tag:
Source (Host):Species:
Product nameHDAC1 Kinetic Assay Kit
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Cat.#:Kit-2283Tag:
Source (Host):Species:
Product nameHDAC1 Immunoprecipitation (IP) & Activity Assay Kit
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Involved Pathway

HDAC1 involved in several pathways and played different roles in them. We selected most pathways HDAC1 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
FAM175A; SKP1; NEK6; CDKN2A; BUB3; DBF4; TUBGCP2; CETN2; HDAC2; PLK4
Notch signaling pathway
RBPJA; RBPJB; DLL1; DLL4; HDAC1; LNX1; PSEN2; DTX3L; EP300; DLB
Thyroid hormone signaling pathway
ATP1B1; MED30; MED12L; MED27; THRA; RHEB; HDAC2; PLCD4; NCOA1; MED1
Huntingtons disease
NDUFA4L2; DNALC4; TBPL1; TP53; NDUFA3; NDUFS7; RCOR1; PLCB3; NDUFV3; POLR2C
Amphetamine addiction
CREB3L2; SLC18A1; PPP1CC; SLC14A2; PDYN; DRD1A; FOS; PRKCG; CAMK2B; GRIA2
Alcoholism
HDAC7; CAMKK2; H2AFZ; HIST1H3D; ATF2; GM14477; HIST3H3; ATF4; PPP1CB; HIST1H4F
Epstein-Barr virus infection
RIPK1; CD58; PSMD6; MAPK11; MAP2K7; MDM2; EIF2AK1; FGR; RBPJ; TRAF5
Pathways in cancer
WNT5A; FGF9; TFG; SKP2; WNT11; FGF22; IKBKG; EGLN3; TPM3; TRAF6
Transcriptional misregulation in cancer
RXRB; ETV6; IL2RB; DOT1L; RUNX1T1; SMAD1; ZBTB16; MLLT1; TSPAN7; NUPR1
Viral carcinogenesis
CREB3L2; TRAF1; CCNA2; BAK1; NFKB2; PXN; CDC42; ACTN4; GTF2H2C; HIST2H2BE
MicroRNAs in cancer
THBS1; CCNE2; BMI1; MMP16; BRCA1; Casp3; MAPK1; BMF; PDGFB; BCL2
Chronic myeloid leukemia
CRKL; TP53; PIK3CG; CBLC; RUNX1; CBLB; STAT5A; GAB2; RELA; PIK3R1

Protein Function

HDAC1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC1 itself. We selected most functions HDAC1 had, and list some proteins which have the same functions with HDAC1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7; HDAC2; HDAC8; HDAC1; HDAC9; HDAC11; HDAC9B; HDAC10; HDAC7A; HDAC3
Function NF-kappaB binding
Related Protein RNF25; AP1S2; BCL10; BRMS1; HIF1AN; FOXP3; GSK3B; COMMD7; PSMA6; HDAC3
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SMARCE1; MTA2; MBD3; GATAD2B; ACTL6A; SMARCC2; HDAC1; SMARCA4; CHD4; SMARCC1
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein SMARCC1; HDAC2; SMARCA4; ACTL6A; RBBP4; GATAD2B; MBD3; MTA2; SMARCB1; CHD4
Function RNA polymerase II repressing transcription factor binding
Related Protein GTF2A2; BBS10; BBS2; HDAC2; SP1; MTA1; HDAC1; BBS4; SIN3A; MIXL1
Function RNA polymerase II transcription corepressor activity
Related Protein UXT; HEYL; CTBP1; SOX3; RERE; TXLNB; HDAC1; TFAP2B; SIN3B; OLIG3
Function activating transcription factor binding
Related Protein PSIP1; SMAD2; GATA4; RELA; PPARG; MEF2D; ATOH8; HDAC7A; TAF9; EP300
Function core promoter binding
Related Protein NEUROG3; SAFB; HDAC5; RELB; MYOG; FOXO3; AGO2; EZH2; ELK1; GATA1
Function deacetylase activity
Related Protein MACROD2; SIRT1; HDAC1; NDST4; AADAC; HDAC2; C6orf130; MAPK1IP1L; NDST3; NDST1
Function enzyme binding
Related Protein RAD9A; KRT79; NOXA1; LAMP1; CBX1; ZNHIT6; STUB1; ABCD1; A2M; CREB1
Function histone deacetylase activity
Related Protein HDAC10; HDAC5; NACC2; HDAC7; HDAC8; SIRT2; HDAC9; HDAC11; SIRT1; HDAC6
Function histone deacetylase binding
Related Protein RFXANK; MECP2; RUNX2; TAL1; ZFP932; MEF2A; HDAC9; ANKRA2; SP1; BRMS1
Function contributes_to nucleosomal DNA binding
Related Protein HDAC2; ACTL6A; RBBP4; CHD4; MTA2; SMARCB1; MBD3; ACTB; HDAC1; GATAD2B
Function protein N-terminus binding
Related Protein MYO7A; NFE2; DCN; HDAC1; KCNIP2; SERPINB1A; ALOX5AP; CSNK2A1; EIF5A; STX1A
Function protein binding
Related Protein TMEM27; DAK; AZIN1; C11orf68; CANX; WLS; MMS19; RTP3; BEX2; STX5
Function protein deacetylase activity
Related Protein HDAC2; HDAC5; HDAC1; HDAC4; SIN3A; HDAC10; SIRT1; SIRT2; HDAC3; HDAC9
Function repressing transcription factor binding
Related Protein CTBP1; HDAC9; SKI; HDAC7; PARK7; HDAC7A; HDAC4; KAT5; MAGEA2B; HDAC1
Function transcription factor activity, sequence-specific DNA binding
Related Protein BHLHE22; BSX; NOTCH1; FLI1A; FEV; ZNF549; IKZF3; HES1; PLAGL2; TBX3A
Function transcription factor binding
Related Protein SORBS3; RNF19A; SOST; JUND; DDIT3; ARHGEF2; RB1; KDM1A; TAF12; HMGA1-RS1
Function transcription regulatory region DNA binding
Related Protein TBX16; ATMIN; ARRB1; IKZF3; CDK5RAP2; MTERFD3; ATF5; GABPB2; Arid4b; TP53
Function transcription regulatory region sequence-specific DNA binding
Related Protein PSPC1; KDM3A; PITX2; SUV39H2; NR5A2; CRY2; NR5A5; MEF2AA; POU2F1; HDAC1

Interacting Protein

HDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC1.
HDAC2; MTA2; RBBP7

HDAC1 Related Articles

Kim, JH; Jee, BC; et al. Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men. YONSEI MEDICAL JOURNAL 55:1333-1340(2014).
Zou, JY; Crews, FT; et al. Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling. PLOS ONE 9:-(2014).