Recombinant Human HDAC1, GST-tagged

• Cat.No.: HDAC1-13703H
• Product Overview: Recombinant Human HDAC1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 183-482a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HDAC1 histone deacetylase 1 [ Homo sapiens ]
• Official Symbol: HDAC1
• Synonyms: HDAC1; histone deacetylase 1; RPD3L1; GON 10; HD1; reduced potassium dependency, yeast homolog-like 1; RPD3; GON-10; DKFZp686H12203
• Gene ID: 3065
• mRNA Refseq: NM_004964
• Protein Refseq: NP_004955
• MIM: 601241
• UniProt ID: Q13547
• Chromosome Location: 1p34
• Pathway: Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); RNA polymerase II transcription corepressor activity; activating trans

Reviews

03/12/2022

The HDAC1 proteins purchased from your company is suitable for ELISA.

09/24/2021

The shipping was prompt enough for me to get into the experiment in the shortest time possible.

12/01/2020

Friendly customer service and detailed answers to all the questions I asked!

Q&As

What diseases has HDAC1 been associated with the study of?

HDAC1 is closely related to the study of diseases such as lung cancer and esophageal squamous carcinoma.

What is the relationship between HDAC1 and Adriamycin?

Adriamycin specifically reduces HDAC1 protein expression.

How is HDAC1 expressed in esophageal squamous carcinoma tissues?

HDAC1 protein is highly expressed in esophageal squamous carcinoma tissues, and its high expression correlates with the development of esophageal squamous carcinoma.

What biological function does HDAC1 have?

HDAC1 is a key enzyme in the histone deacetylation process and is involved in the regulation of histone acetylation levels.