Recombinant Human HDAC1, GST-tagged

Cat.No. : HDAC1-13703H
Product Overview : Recombinant Human HDAC1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Source : E.coli
Species : Human
Tag : GST
Protein length : 183-482a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : HDAC1 histone deacetylase 1 [ Homo sapiens ]
Official Symbol : HDAC1
Synonyms : HDAC1; histone deacetylase 1; RPD3L1; GON 10; HD1; reduced potassium dependency, yeast homolog-like 1; RPD3; GON-10; DKFZp686H12203;
Gene ID : 3065
mRNA Refseq : NM_004964
Protein Refseq : NP_004955
MIM : 601241
UniProt ID : Q13547
Chromosome Location : 1p34
Pathway : Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); RNA polymerase II transcription corepressor activity; activating trans

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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What diseases has HDAC1 been associated with the study of? 08/13/2022

HDAC1 is closely related to the study of diseases such as lung cancer and esophageal squamous carcinoma.

What is the relationship between HDAC1 and Adriamycin? 07/14/2022

Adriamycin specifically reduces HDAC1 protein expression.

How is HDAC1 expressed in esophageal squamous carcinoma tissues? 01/25/2022

HDAC1 protein is highly expressed in esophageal squamous carcinoma tissues, and its high expression correlates with the development of esophageal squamous carcinoma.

What biological function does HDAC1 have? 03/13/2021

HDAC1 is a key enzyme in the histone deacetylation process and is involved in the regulation of histone acetylation levels.

Customer Reviews (3)

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03/12/2022

    The HDAC1 proteins purchased from your company is suitable for ELISA.

    09/24/2021

      The shipping was prompt enough for me to get into the experiment in the shortest time possible.

      12/01/2020

        Friendly customer service and detailed answers to all the questions I asked!

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