Recombinant Mouse Hdac1 Protein, Myc/DDK-tagged

• Cat.No.: Hdac1-3366M
• Product Overview: Purified recombinant protein of mouse full-length histone deacetylase 1 (Hdac1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 55.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hdac1 histone deacetylase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Hdac1
• Synonyms: HDAC1; histone deacetylase 1; HD1; RPD3; MommeD5; Hdac1-ps; MGC102534; MGC118085
• Gene ID: 433759
• mRNA Refseq: NM_008228
• Protein Refseq: NP_032254
• UniProt ID: O09106

Reviews

03/12/2022

The HDAC1 proteins purchased from your company is suitable for ELISA.

09/24/2021

The shipping was prompt enough for me to get into the experiment in the shortest time possible.

12/01/2020

Friendly customer service and detailed answers to all the questions I asked!

Q&As

What diseases has HDAC1 been associated with the study of?

HDAC1 is closely related to the study of diseases such as lung cancer and esophageal squamous carcinoma.

What is the relationship between HDAC1 and Adriamycin?

Adriamycin specifically reduces HDAC1 protein expression.

How is HDAC1 expressed in esophageal squamous carcinoma tissues?

HDAC1 protein is highly expressed in esophageal squamous carcinoma tissues, and its high expression correlates with the development of esophageal squamous carcinoma.

What biological function does HDAC1 have?

HDAC1 is a key enzyme in the histone deacetylation process and is involved in the regulation of histone acetylation levels.