HDAC10
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Official Full Name
histone deacetylase 10 -
Overview
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HDAC10;histone deacetylase 10;DKFZP761B039;HD10;MGC149722
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- GST
- His
- Flag
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
HDAC10 involved in several pathways and played different roles in them. We selected most pathways HDAC10 participated on our site, such as Alcoholism,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | YWHAG,GTF2E1,ACTN1,GTF2E2,HIST1H2BN,HPN,CCNA2,HDAC7,PKM,HIST1H2BI |
| Alcoholism | CALML5,H3F3C,GNG13,H2AFY,GM14478,HIST3H2A,HIST1H2AO,HIST1H4J,NTRK2,HIST1H3F |
Protein Function
HDAC10 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),enzyme binding,histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC10 itself. We selected most functions HDAC10 had, and list some proteins which have the same functions with HDAC10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein deacetylase activity | HDAC1,HDAC2,HDAC4,SIN3A,HDAC9,SIRT2,SIRT1,HDAC3,HDAC5 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC4,HDAC2,HDAC7,HDAC1,HDAC3,HDAC8,HDAC9B,HDAC9,HDAC5,HDAC6 |
| enzyme binding | PCCA,PDE4D,SCN5A,NKX2-1,MAPT,SLC27A2,POR,MDM2,PCBP2,LDB2 |
| protein binding | RBFOX2,TRPV5,RGS14,NPPB,COX5B,DARS,SNAPC5,POU1F1,CRY1A,POLI |
| histone deacetylase binding | CCND1,RELA,PARK2,HDAC3,PHB,KAT2B,SP1,MYOCD,ANKRD1,GMNN |
| histone deacetylase activity | SIRT2,HDAC9B,HDAC11,HDAC9,NACC2,HDAC8,MTA2,HDAC3,HDAC2,HDAC5 |
Interacting Protein
HDAC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC10.
HDAC3;HDAC2;NCOR2;P4HA1;RAC2;PDIA3;DNAJA1;FDFT1;COPB1;TXNDC5
HDAC10 Related Signal Pathway
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