hecw1
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  • Official Full Name
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  • Synonyms
  • HECW1;HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1;22195;ENSG00000002746;NEDL1;7p13;KIAA0322;E3 ubiquitin-protein ligase HECW1;E3 ubiquitin-protein ligase HECW1;HECT type E3 ubiquitin ligase;NEDD4-like ubiquitin-protein ligase 1;NEDD4-like E3 ubiquitin-protein ligase 1;HECT, C2 and WW domain-containing protein 1;
Cat.#:HECW1-13728HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HECW1, His-tagged
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Cat.#:HECW1-7563MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HECW1 Protein
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Cat.#:HECW1-2063RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HECW1 Protein, His-tagged
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Involved Pathway

HECW1 involved in several pathways and played different roles in them. We selected most pathways HECW1 participated on our site, such as Degradation of DVL, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with HECW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of DVL
DVL3; HECW1; HECW1B; KLHL12; DVL2; DVL1; DACT1
Signal Transduction
CALML4; RNF43; GPR177; EVC2; RGS6; ARHGEF1B; TMED5; RBP4; AKAP13; RAB6A
Signaling by Wnt
PRICKLE1; BCL9; KREMEN2; LGR4; SOX9B; LGR5; CSNK1G2; PYGO1; RSPO3; CCDC88C
TCF dependent signaling in response to WNT
LEO1; HECW1B; C; BCL9L; PYGO1; SOX6; DACT1; USP34; HECW1; ZNRF3

Protein Function

HECW1 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HECW1 itself. We selected most functions HECW1 had, and list some proteins which have the same functions with HECW1. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein TRIM56; UBR1; TRIM8; TRIM27; TRIM11; RNF6; ARIH1L; MUL1A; PDZRN3; NAPRT1
Function ubiquitin protein ligase activity
Related Protein MED1; RNF144B; RNF19B; CDC42; UBE2S; UBE2U; BRAP; RNF7; RNF111; MSL2A

Interacting Protein

HECW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HECW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HECW1.
FBXL15; CACNA1A; GFI1B; USP7; MPHOSPH8

HECW1 Related Articles

Zhi, X; Chen, CS; et al. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. CELLULAR AND MOLECULAR LIFE SCIENCES 69:1425-1434(2012).
Li, Y; Zhou, Z; et al. WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. ONCOGENE 28:2948-2958(2009).