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HEYL

  • Official Full Name

    hairy/enhancer-of-split related with YRPW motif-like

  • Overview

    Heyl is a member of the Hairy/ Enhancer of split (E(spl))-related with YRPW motif (Hey) genes, which are a subfamily of mammalian (E(spl))-related basic helix-loop-helix (bHLH) genes that encode a carboxy-terminal KPYRPWG sequence3. The proteins are also
  • Synonyms

    HEYL; hairy/enhancer-of-split related with YRPW motif-like; hairy/enhancer-of-split related with YRPW motif-like protein; bHLHb33; hairy/enhancer of split related with YRPW motif 3; HEY3; HRT-3; hHRT3; hHeyL; HEY-like protein; hairy-related transcription;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HEYL-13757H Recombinant Human HEYL, His-tagged E.coli His 1-328a.a.
Human HEYL-4719H Recombinant Human HEYL Protein, GST-tagged Wheat Germ GST
Human HEYL-5573HCL Recombinant Human HEYL 293 Cell Lysate HEK293 N/A
Human HEYL-3530HF Recombinant Full Length Human HEYL Protein, GST-tagged In Vitro Cell Free System GST 328 amino acids
Mouse HEYL-7600M Recombinant Mouse HEYL Protein Mammalian Cell His
Mouse HEYL-4143M-B Recombinant Mouse HEYL Protein Pre-coupled Magnetic Beads HEK293
Mouse HEYL-4143M Recombinant Mouse HEYL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HEYL-9634Z Recombinant Zebrafish HEYL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HEYL Related Articles

HEYL involved in several pathways and played different roles in them. We selected most pathways HEYL participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEYL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsHDAC5;CCNC;JAG1;HDAC6;HEY2;HEYL;CDK8;HEY1;ADAM10
Constitutive Signaling by NOTCH1 PEST Domain MutantsCDK8;HEY1;ADAM10;HDAC6;CCNC;HEY2;MIB1;JAG1;HDAC5
DiseaseCCDC167;PDCD6IP;OPN1MW2;CYP11A1;GYG2;TCEB3;AP1M2;HEYL;AP1B1
Diseases of signal transductionOPN1MW;TRAT1;MYO18A;RBP1;CCNC;CDK8;HDAC5;KREMEN1;CDC37
NOTCH1 Intracellular Domain Regulates TranscriptionTLE3;TLE1;HEY2;HEYL;TLE2;HEY1;TLE4;TUBB3
Signal TransductionGRB10A;ADM2A;LPAR2A;FSTL1;RNF43;MYO9B;APOA4A;NPSR1;RDH14B
Signaling by NOTCHDTX2;DNER;TLE2;TLE4;MDK;DLK1;MDKB;MDKA;RAB6A
Signaling by NOTCH1DLK1;DNER;HEYL;DTX2;TLE3

HEYL has several biochemical functions, for example, AF-1 domain binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEYL itself. We selected most functions HEYL had, and list some proteins which have the same functions with HEYL. You can find most of the proteins on our site.

Function Related Protein
AF-1 domain binding
RNA polymerase II core promoter sequence-specific DNA bindingSP3;TAL1;H2AFY;PAX6;ZNF277;EP300;H3F3B;TP53;ZFP335
RNA polymerase II transcription corepressor activityOLIG3;HEYL;TCERG1;URI1;HDGF;SIN3A;RBBP8;CTBP1;UXT
microsatellite bindingHEY1;HEY2;HEYL
protein bindingBRK1;C19orf44;CAPZA1;CUL4A;TLE2;FEM1B;RXRB;KLF13;LMO2
protein heterodimerization activityHIST1H2BB;HIST1H3A;TFAP2B;RBP4;BCL2A;Fzd4;MAFA;MCL1B;GCLC
protein homodimerization activityHSP90AA1;GNPTG;GRM6;SUMF1;VWF;CTSE;MBL1;CADM1;NLRC4
transcription corepressor activityBCOR;CDX2;RLIM;MNT;TFAP2B;SP100;MECP2;TBL1XR1A;DRAP1
transcription factor activity, RNA polymerase II core promoter sequence-specificTFAP2B;MEF2C;PAX7;HEY2;NKX3;MAX;HEYL;SMAD3;HEY1
transcription factor activity, protein bindingHEYL;HEY1;HEY2
transcription factor activity, sequence-specific DNA bindingZNF287;USF2;SOLH;MYRFL;BACH1A;TAF13;ZSCAN4F;HMGA1;FOXP4
transcription factor bindingPSMC5;NIF3L1;NAB2;ETS1;VDRA;AHR;TP73;SOX10;TBX5
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTFAP2C;CDX4;HEYL;Ar;ISL1;STAT3;DLX3;POU3F2;POU2F2

HEYL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEYL here. Most of them are supplied by our site. Hope this information will be useful for your research of HEYL.

RBPMS; MDFI; RPGRIP1; SMAD7; SMAD9; SKIL; HTT; ATXN1; PPP1CA; SMAD3; LAPTM5; ATF7IP

Fukada, S; et al. Molecular Regulation of Muscle Stem Cells by 'Quiescence Genes'. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131:1329-1332(2011).
Chen, LH; Al-Awqati, Q; et al. Segmental expression of Notch and Hairy genes in nephrogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 288:F939-F952(2005).
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