heyl
Share
  • Official Full Name
  • hairy/enhancer-of-split related with YRPW motif-like
  • Background
  • Heyl is a member of the Hairy/ Enhancer of split (E(spl))-related with YRPW motif (Hey) genes, which are a subfamily of mammalian (E(spl))-related basic helix-loop-helix (bHLH) genes that encode a carboxy-terminal KPYRPWG sequence3. The proteins are also
  • Synonyms
  • HEYL; hairy/enhancer-of-split related with YRPW motif-like; hairy/enhancer-of-split related with YRPW motif-like protein; bHLHb33; hairy/enhancer of split related with YRPW motif 3; HEY3; HRT-3; hHRT3; hHeyL; HEY-like protein; hairy-related transcription
Cat.#:HEYL-4719HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HEYL Protein, GST-tagged
+Inquiry
Cat.#:HEYL-13757HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEYL, His-tagged
+Inquiry
Cat.#:HEYL-7600MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HEYL Protein
+Inquiry
Cat.#:HEYL-9634ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HEYL
+Inquiry
Cat.#:HEYL-5573HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HEYL 293 Cell Lysate
+Inquiry

Involved Pathway

HEYL involved in several pathways and played different roles in them. We selected most pathways HEYL participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEYL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
JAG2; JAG1; ADAM10; CCNC; CDK8; HDAC5; HDAC6; HEYL; MIB1; HEY2
Constitutive Signaling by NOTCH1 PEST Domain Mutants
HDAC6; HEY2; JAG2; MIB1; JAG1; CDK8; HEYL; CCNC; ADAM10; HDAC5
Disease
PRELP; RBP4; PPIAL4A; CTDP1; TCEA1; KREMEN1; JAG1; MMADHC; TCEB3; TNKS2
Diseases of signal transduction
TRAT1; CTBP1; OPN1MW2; CCNC; TTR; OPN1LW; CPSF6; OS9; RNF43; LRRFIP1
NOTCH1 Intracellular Domain Regulates Transcription
TLE2; HEY2; TUBB3; HEY1; TLE3; HEYL; TLE1; TLE4
Signal Transduction
IFT52; TAGAP1; LGR5; ABI1A; LINGO1; ALDH8A1; DZIP1; FAM13A; RAMP1; TAS2R13
Signaling by NOTCH
TLE2; MDKA; HEYL; TLE3; DLK1; MDKB; MDK; TLE4; DNER; DTX2
Signaling by NOTCH1
DLK1; HEYL; DNER; TLE3; DTX2

Protein Function

HEYL has several biochemical functions, for example, AF-1 domain binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEYL itself. We selected most functions HEYL had, and list some proteins which have the same functions with HEYL. You can find most of the proteins on our site.
Function
Related Protein
Function AF-1 domain binding
Related Protein HEYL
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein MTF1; STAT5A; RUNX2; SP1; STAT6; TRP53; FOS; HNF4A; TCF7L2; MITF
Function RNA polymerase II transcription corepressor activity
Related Protein TBX15; N4BP2L2; SOX3; SIN3AA; OLIG3; CTBP1; RBBP8; TCERG1; HEYL; TLE1
Function microsatellite binding
Related Protein HEY1; HEYL; HEY2
Function protein binding
Related Protein IKBKG; RAB2A; GOLGA1; MX2; S100A11; PIH1D1; SAMM50; ERO1L; GRIN3A; ZBTB44
Function protein heterodimerization activity
Related Protein SNX5; PPP1CBL; TAS1R1; SFRP5; CREB3L3; WHRN; VEGFB; MLXIPL; SOX17; ANO2
Function protein homodimerization activity
Related Protein DMRT1; MYOM3; NR2C1; DAPK3; TRIM5; TENM1; SYNDIG1; TOX3; PPP2R4; HNF4A
Function transcription corepressor activity
Related Protein ATF3; PPP1R13L; TAF9B; CBFA2T2; RCOR2; NR0B2A; HDAC5; KLF12; HIPK2; ASXL1
Function transcription factor activity, RNA polymerase II core promoter sequence-specific
Related Protein TFAP2B; HEYL; HEY1; MAX; PAX7; NKX3; SMAD3; MEF2C; HEY2
Function transcription factor activity, protein binding
Related Protein HEY1; HEY2; HEYL
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXO3A; ZFP161; HNF4A; THRA; RAI1; HOXB2; SALL1; TCF12; TFE3; HOXB6
Function transcription factor binding
Related Protein PIK3R1; CTBP1; SOST; CDKN2A; LCOR; NFATC3; CD34; APBB2; PARK7; PIAS1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein ETV6; POU4F3; ATF2; MEIS3; GABPA; NUCKS1; GATA1; PHOX2B; RELA; PLSCR1

Interacting Protein

HEYL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEYL here. Most of them are supplied by our site. Hope this information will be useful for your research of HEYL.
RBPMS; MDFI; RPGRIP1; SMAD7; SMAD9; SKIL; HTT; ATXN1; PPP1CA; SMAD3; LAPTM5; ATF7IP

HEYL Related Articles

Fukada, S; et al. Molecular Regulation of Muscle Stem Cells by 'Quiescence Genes'. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131:1329-1332(2011).
Chen, LH; Al-Awqati, Q; et al. Segmental expression of Notch and Hairy genes in nephrogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 288:F939-F952(2005).