HSPA1B
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Official Full Name
heat shock 70kDa protein 1B -
Overview
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. -
Synonyms
HSPA1B;heat shock 70kDa protein 1B;heat shock 70kD protein 1B;heat shock 70 kDa protein 1A/1B;HSP70 2;HSP70-1/HSP70-2;HSP70.1/HSP70.2;heat shock 70 kDa protein 1/2;HSPA1A;HSP70-2;HSP70-1B;FLJ54328
Recombinant Proteins
- Human
- Cattle
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- Non
- GST
- SUMO
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HSPA1B-29395TH | Recombinant Human HSPA1B, His-tagged | E.coli | Human | His | Full L. |
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| HSPA1B-29397TH | Recombinant Human HSPA1B | E.coli | Human | Non | Full L. |
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| HSPA1B-29399TH | Recombinant Human HSPA1B, His-tagged | Human | His | Full L. |
|
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| HSPA1B-29401TH | Recombinant Human HSPA1B | Human | Non | Full L. |
|
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| HSPA1B-29402TH | Recombinant Human HSPA1B | E.coli | Human | Non | Full L. |
|
| HSPA1B-402C | Recombinant Cattle HSPA1B Protein, His-tagged | E.coli | Cattle | His | Met1~Asp641 |
|
| Hspa1b-403M | Recombinant Mouse Hspa1b Protein, His-tagged | E.coli | Mouse | His | Met1~Asp642 |
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| HSPA1B-5102H | Recombinant Human HSPA1B Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HSPA1B-7905M | Recombinant Mouse HSPA1B Protein | Mammalian Cells | Mouse | His |
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| HSPA1B-2623H | Recombinant Human HSPA1B protein(381-610 aa), C-His-tagged | E.coli | Human | His | 381-610 aa |
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| Hspa1b-3057M | Recombinant Mouse Hspa1b protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | 2-642aa |
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| HSPA1B-4355M | Recombinant Mouse HSPA1B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HSPA1B-4355M-B | Recombinant Mouse HSPA1B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HSPA1B involved in several pathways and played different roles in them. We selected most pathways HSPA1B participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PLD2,ACAP2,SNX6,ERBB3,ZFYVE27,DDL-2,EPS15L1,CHMP2BA,RAB11FIP4,ASAP2A |
| Protein processing in endoplasmic reticulum | RRBP1,PKZ,DNAJC5B,BCAP31,SEC24B,LMAN1,UGGT2,HSP90AA1.1,DNAJC5G,RNF185 |
| Legionellosis | PYCARD,SAR1B,ITGAM,RAB1B,APAF1,HSPA1L,NAIP1,NFKBIA,HSPA1A,Itgam&Itgb2 |
| Spliceosome | PPIL1,U2AF2B,SF3B3,PUF60A,U2AF2A,HNRNPK,SF3A1,SNRPF,SF3B5,CTNNBL1 |
| Influenza A | PIK3CD,IFNAR2,IFNA7,LOC100686744,HLA-DRB5,IFIH1,IFNA3,TNFRSF10C,GSK3B,NFKBIA |
| Measles | IL2RB,PIK3R1,MAP3K7,CD3E,IFNA6,IFNA17,CD209A,MAVS,IFNA7,Ifna11 |
| Estrogen signaling pathway | PIK3R1,HSP90AA1,KCNJ6,FKBP4,PIK3CA,PRKACB,KRAS,GABBR1,SRC,MAP2K2 |
| MAPK signaling pathway | JIP1,FLNA,MAP2K4A,RASGRF2B,TRP53,DUSP3,NRAS,CACNG4,PRKACB,TRAF2 |
| Epstein-Barr virus infection | HLA-DPA1,TBK1,PSMC3,ENTPD1,IL10RA,YWHAE,IRF3,GTF2B,HSPA1A,SPI1 |
Protein Function
HSPA1B has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1B itself. We selected most functions HSPA1B had, and list some proteins which have the same functions with HSPA1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | USP25,XBP1,RNF20,EIF4E2,VCP,PRKAR2B,LC3,Fzd4,JAK1,NDUFS2 |
| ATPase activity | ATAD1B,DNAHC8,ACTC1,KIF2C,CENPE,SWSAP1,BLM,ABCA6,ATP13A,VPS4A |
| receptor binding | FZD1,PTK2,PTK2BB,NTF7,WNT2BB,DIAPH1,LGI1,SRC,SCYL2,APLN |
| C3HC4-type RING finger domain binding | KCNH2,HSPA8,HSPA1A,DNAJA1,PINK1 |
| ATP binding | RAD54B,CKMT2B,PHKG1,GTF2F2,DDX39A,MAP2K4A,CDK1,NSFB,MARS2,ACVR1C |
| G-protein coupled receptor binding | PROK2,RSPO3,GNAI2A,NPFFL,INSL3,GNA11B,GNA13B,RSPO1,UCN3,GNAT3 |
| heat shock protein binding | DAXX,BAK1,FAF1,NFKBIA,DLST,GRXCR2,PPID,TFAM,CDC37,HDAC2 |
| enzyme binding | HAND2,KDM4C,DHCR24,CDK19,RXRA,HDAC2,SIRT3,PLCB1,HDHD2,RPS2 |
| unfolded protein binding | PFDN2,TCP1,CCT8,RUVBL2,DNAJA2,H2-KE2,HSP90AA1,HSPA9,HSP90B1,DNAJB6 |
Interacting Protein
HSPA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1B.
EGFR;STUB1;SNCA;HSP90AA1
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References
- Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
- Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).
