HSPA1B Protein, heat shock 70kDa protein 1B

HSPA1B

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HSPA1B

Official Full Name heat shock 70kDa protein 1B
Background This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Synonyms HSPA1B; heat shock 70kDa protein 1B; heat shock 70kD protein 1B; heat shock 70 kDa protein 1A/1B; HSP70 2; HSP70-1/HSP70-2; HSP70.1/HSP70.2; heat shock 70 kDa protein 1/2; HSPA1A; HSP70-2; HSP70-1B; FLJ54328
    • Species :
    • Cattle
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA1B-28995TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-29395TH Recombinant Human HSPA1B, His-tagged E.coli His
    Human HSPA1B-29397TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-29399TH Recombinant Human HSPA1B, His-tagged His
    Human HSPA1B-29401TH Recombinant Human HSPA1B N/A
    Human HSPA1B-29402TH Recombinant Human HSPA1B E.coli N/A
    Human HSPA1B-5102H Recombinant Human HSPA1B Protein, GST-tagged Wheat Germ GST
    Mouse Hspa1b-403M Recombinant Mouse Hspa1b Protein, His-tagged E.coli His
    Mouse HSPA1B-7905M Recombinant Mouse HSPA1B Protein Mammalian Cell His
    Cattle HSPA1B-402C Recombinant Cattle HSPA1B Protein, His-tagged E.coli His

    HSPA1B involved in several pathways and played different roles in them. We selected most pathways HSPA1B participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome LSM4; CHERP; ALYREF; PQBP1; SRSF3; SR140; RBM8A; SF3A2; XAB2; HNRNPK
    MAPK signaling pathway NTF3; PPM1BA; PRKACG; FGF10A; FGF22; CACNB2A; MAPK3; MKNK2A; GADD45BB; GRB2B
    Protein processing in endoplasmic reticulum UBE2D2L; DNAJC5AA; STT3A; CALRL2; RNF185; ATF6; ATXN3L; UBE2J2; UBE4B; SAR1B
    Endocytosis KIF5A; HLA-G; TGFBR1A; KITA; VPS4A; TFR1A; ARPC5B; VPS37D; SMURF1; SNX2
    Antigen processing and presentation KIR3DL2; KLRC4; HLA-DMB; H2-Q10; HLA-DPA1; CD8B; HLA-DQA2; HSPA1A; HSPA1B; HLA-DMA
    Estrogen signaling pathway HSP90AA1; CREB3L2; KCNJ5; PIK3R2; MAPK1; KCNJ6; HSPA1L; CALM3; CALML5; PIK3CA
    Legionellosis C3; NAIP6; TNF; HSPA8; CXCL1; HSF1; CASP9; ITGAM; TLR5; IL-8
    Toxoplasmosis CASP8; BCL2; MAPK8; STAT1; IFNG; Casp3; MAPK3; MAPK10; CD40LG; LAMC2
    Measles EIF2AK3; TYK2; OAS1; FAS; IL2RA; Ifna11; IL4; CD3E; IKBKE; TNFRSF10A
    Influenza A IL-8; HLA-DQB1; MAVS; ICAM1; IFNG; HSPA1A; IL12B; XPO1; PIK3CA; VDAC1
    Epstein-Barr virus infection HLA-G; PLCG2; RAN; POLR3GL; CCNA1; PIK3R5; TBPL1; SYK; HSPA8; NEDD4

    HSPA1B has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1B itself. We selected most functions HSPA1B had, and list some proteins which have the same functions with HSPA1B. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP2K5; PNKP; PIK3C3; RUNX2A; ACSL3; SLKA; TNK2; UBE2Q2; HSP90AA1.2; ATP2B4
    ATPase activity ATAD1B; HLTF; KIF4; ABCF3; TOR1A; KIF12; PSMC6; VPS4A; MLH3; ABCA4
    ATPase activity, coupled PEX1; MYH3; NSF; HSPA8; HSPA1B; HSPA6; MYO1E; ABCB1A; VPS4A; HSP104
    C3HC4-type RING finger domain binding KCNH2; HSPA1A; PINK1; HSPA1B; DNAJA1; HSPA8
    G-protein coupled receptor binding PPY; NPB; CORT; GPRC5B; GNAV1; SFTPB; GNAI2B; UCN3; HSPA1A; GNA15
    enzyme binding EGLN1; ZFHX3; ATG3; PHKG2; KALRN; HSPA5; PARK2; APBA3; SNX12; HDAC2
    heat shock protein binding APAF1; DNAJB6; SSUH2RS1; HSPA6; DNAJA3B; DNAJA3; TOMM34; BAK1; DAXX; GPR37
    protein binding Pilrb1; Casp3; ATG4A; C1QTNF9B-AS1; NLRC4; RAC3; BPTF; HOXB6; STX6; DARS2
    protein binding involved in protein folding HSPA1A; PFDN1; PDCL3; CLGN; RIC3; DNAJB8; CALR3; CD74; PFDN2; CALR
    receptor binding LPL; INSL3; APP; IZUMO1; SRPX2; FZD1; DECR2; Fert2; CXADR; P2RX4
    ubiquitin protein ligase binding ARIH1; ARRB2; VCP; BAG5; ATXN3; UBE2B; SMC6; CXCR4; HSPA9; AMBRA1
    unfolded protein binding DNAJB5; CRYABB; CCT7; CCT2; HSP90B1; AIP; GRPEL1; HSPA2; MKKS; NAP1L4
    virus receptor activity TNFRSF14; SERPINB4; SLC52A2; HLA-DRB1; CD4; HTR2A; AXL; SLC10A1; CXADR; PVRL1

    HSPA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1B.

    EGFR; STUB1; SNCA; HSP90AA1

    Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).

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