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HSPA4

  • Official Full Name

    heat shock 70kDa protein 4

  • Overview

    Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients
  • Synonyms

    HSPA4; heat shock 70kDa protein 4; heat shock 70kD protein 4; heat shock 70 kDa protein 4; HS24/P52; hsp70 RY; HSPH2; heat shock protein, 110 kDa; heat shock 70-related protein APG-2; RY; APG-2; hsp70; hsp70RY; MGC131852;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA4-1560H Active Recombinant Human HSPA4 Protein (Full Length, 1-641) E.coli 1-641
Human HSPA4-8938H Recombinant Human HSPA4, GST-tagged E.coli GST False
Human HSPA4-16H Recombinant Human HSPA4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSPA4-17H Recombinant Human HSPA4 protein, His/T7-tagged E.coli His/T7
Human HSPA4-5106H Recombinant Human HSPA4 Protein, GST-tagged Wheat Germ GST
Human HSPA4-2550H Recombinant Human HSPA4 E.coli N/A
Human HSPA4-823HCL Recombinant Human HSPA4 cell lysate N/A
Human HSPA4-7441HFL Recombinant Full Length Human HSPA4 protein, Flag-tagged Mamanlian cells Flag
Human HSPA4-5743H Recombinant Human HSPA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSPA4-012H Active Recombinant Human HSPA4 Protein Insect Cell 2-641
Human HSPA4-3088H Recombinant Human HSPA4 Protein (Ser258-Glu511), N-His tagged E.coli N-His Ser258-Glu511
Human HSPA4-898H Recombinant Human HSPA4 protein, GST-tagged E. coli GST 291-641 aa
Human HSPA4-3819HF Recombinant Full Length Human HSPA4 Protein, GST-tagged In Vitro Cell Free System GST 148 amino acids
Human HSPA4-015H Active Recombinant Human HSPA4 Protein Insect Cell 2-641
Mouse Hspa4-1191M Recombinant Mouse Hspa4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HSPA4-2947R Recombinant Rat HSPA4 Protein Mammalian Cell His
Rat HSPA4-2602R Recombinant Rat HSPA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSPA4-2602R-B Recombinant Rat HSPA4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA4 Related Research Area

HSPA4 involved in several pathways and played different roles in them. We selected most pathways HSPA4 participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationHSPA6;HSPA1B;RFX5;Ctsl;KIR2DS3;HLA-A;B2M;HLA-DPA1;KLRC4

HSPA4 has several biochemical functions, for example, ATP binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA4 itself. We selected most functions HSPA4 had, and list some proteins which have the same functions with HSPA4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP8B1;MCM9;UCK2B;ACTB1;DYNC2H1;FIGN;STK25B;NEK11;HK3
protein bindingTXNDC12;ACCS;PDLIM2;CDK1;SZT2;CDT1;PSMB8;RAB5C;C1orf109

HSPA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA4.

AGTRAP; APPBP2; EGFR; P; HSPA8; YWHAZ; TRAF2; TAB1; MAP3K3; GAMMAHV.ORF40; PRSS23; HSPB1; CDC73

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can HSPA4 protein be used in personalized medicine? 05/29/2021

Understanding the role of HSPA4 protein in disease may lead to personalized treatment strategies based on an individual's protein expression levels.

How is HSPA4 protein regulated in cells? 01/15/2020

HSPA4 protein is regulated by various cellular pathways, including heat shock response and other stress-related signaling mechanisms.

How is HSPA4 protein involved in cardiovascular diseases? 04/24/2018

HSPA4 protein has been linked to the protection of cardiac cells during stress conditions, making it a potential target for heart disease treatment.

Are there any diagnostic tests for HSPA4 protein levels? 02/18/2018

Some research laboratories offer diagnostic tests for HSPA4 protein levels, particularly in the context of cancer diagnosis and monitoring.

Can HSPA4 protein be targeted for drug development? 04/23/2017

Researchers are exploring the possibility of developing drugs that modulate HSPA4 protein activity as a potential treatment for various diseases.

Customer Reviews (3)

Write a review
Reviews
02/06/2020

    The impressive performance of the HSPA4 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

    11/18/2017

      The HSPA4 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.

      07/09/2017

        Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

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