ifi16
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  • Official Full Name
  • interferon, gamma-inducible protein 16
  • Background
  • IFI16 belongs to the PYHIN family, which consists of four members in humans (Aim2, IFIX, MNDA, and IFI16) and at least thirteen members in mice. The closest homolog of IFI16 in mice is p204. The PYHIN family is characterized by the presence of one or two
  • Synonyms
  • IFI16; interferon, gamma-inducible protein 16; gamma-interferon-inducible protein 16; IFNGIP1; PYHIN2; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; MGC9466
Cat.#:IFI16-14060HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFI16, GST-tagged
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Cat.#:IFI16-1946HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFI16 protein, His & T7-tagged
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Cat.#:IFI16-26947THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IFI16
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Cat.#:IFI16-2197RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFI16 Protein, His-tagged
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Cat.#:IFI16-5297HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IFI16 293 Cell Lysate
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Involved Pathway

IFI16 involved in several pathways and played different roles in them. We selected most pathways IFI16 participated on our site, such as Cytosolic sensors of pathogen-associated DNA, IRF3-mediated induction of type I IFN, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFI16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytosolic sensors of pathogen-associated DNA
CRCP; MB21D1; POLR3H; NLRP4B; POLR3GLA; S100A12; TICAM1; IFI16; TRIM56; S100B
IRF3-mediated induction of type I IFN
IFI16; TREX1; NLRP4C; NLRP4E; NLRP4B; DDX41; NLRP4
Id Signaling Pathway
ELK3; TCF12; MYF6; PAX2; MYOD1; MSC; MYOG; IFI16; TCF3B; ACVRL1
Immune System
LILRA3; IGHM; LGALS3; KIF3B; CD200R1; S100A12; GHRB; DEFB121; SIGIRR; TXNIPA
Innate Immune System
DEFB4A; TNRC5; CLEC4A; PPAPDC1B; S100A12; BTR06; WIPF2; CTS7; DEFB106A; ACTR2B
STING mediated induction of host immune responses
NLRP4C; TREX1; DDX41; NLRP4; MB21D1; NLRP4B; NLRP4E; IFI16
Senescence and Autophagy
LC3; RB1CC1; IL24; GABARAPL2; AMBRA1; UVRAG; COL10A1; GABARAP; SLC39A1; ING2

Protein Function

IFI16 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter binding, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFI16 itself. We selected most functions IFI16 had, and list some proteins which have the same functions with IFI16. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein CDX4; ZFP746; FOSL1; MITFB; PER1; HOXA2; AGO1; HINFP; SREBF1; TLX1
Function core promoter binding
Related Protein MED1; KDM3A; GATA1; NKX3; AGO2; GTF2B; E2F7; MTF1; MTA1; SAFB
Function double-stranded DNA binding
Related Protein DMC1; RAD51AP1; TRP53; HNRPDL; SAFB; SMAD2; APTX; DDX11; IFI16; FBXO18
Function identical protein binding
Related Protein LCP1; ACADM; ATF3; PTEN; PIK3AP1; SEPT7; USP4; BAK1; AIRE; SORD
Function poly(A) RNA binding
Related Protein RPL14; C14orf93; ERAL1; APEH; HSPA8; NOC2L; PKM; EIF1AX; RPS8; SUPT6H
Function protein binding
Related Protein NOTCH2; PAM; CCDC50; NCK1; ESR2; CCDC25; NFASC; KIAA0146; IL10RA; TAF9B
Function transcription factor binding
Related Protein PAX6; KCTD1; FOXO1; STK4; CSNK2B; TFDP2; NR0B1; PPARGC1B; PPARGC1A; MAPK1
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein PROX1B; HSF1; HELT; NR2C1; CUX2; TGIF1; NFIL3-6; SP3; FOXO1; GZF1

Interacting Protein

IFI16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFI16 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFI16.
BRCA1; AR; TMEM173; TP53; SP1; Tmem173; q7ard3_yerpe; hofG

IFI16 Related Articles

Connolly, DJ; Bowie, AG; et al. The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease. BIOCHEMICAL PHARMACOLOGY 92:405-414(2014).
Suzuki, T; Oshiumi, H; et al. Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA. PLOS ONE 8:-(2013).