ifih1
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  • Official Full Name
  • interferon induced with helicase C domain 1
  • Background
  • Interferon-induced helicase C domain-containing protein 1, also know as MDA5 (Melanoma Differentiation-Associated protein 5), is an enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.
  • Synonyms
  • IFIH1; interferon induced with helicase C domain 1; Hlcd; MDA5; MDA-5; IDDM19; MGC133047; interferon-induced helicase C domain-containing protein 1; helicard; OTTHUMP00000162935; CADM-140 autoantigen; helicase with 2 CARD domains; RNA helicase-DEAD box protein 116; murabutide down-regulated protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; melanoma differentiation associated protein-5; melanoma differentiation-associated protein 5; interferon-induced with helicase C domain protein 1; clinically amyopathic dermatomyositis autoantigen 140 kDa
Cat.#:IFIH1-1252HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFIH1 Protein, His-tagged
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Cat.#:IFIH1-1861HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFIH1 protein, His-tagged
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Cat.#:IFIH1-28633THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IFIH1
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Cat.#:IFIH1-8013MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IFIH1 Protein
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Cat.#:IFIH1-2201RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFIH1 Protein, His-tagged
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Cat.#:IFIH1-4122CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IFIH1
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Cat.#:IFIH1-5289HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IFIH1 293 Cell Lysate
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Involved Pathway

IFIH1 involved in several pathways and played different roles in them. We selected most pathways IFIH1 participated on our site, such as RIG-I-like receptor signaling pathway, Hepatitis B, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFIH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RIG-I-like receptor signaling pathway
MAPK9; TRAF3; IL8L2; PIN1; IFNA13; OTUD5A; SIKE1; AZI2; TBK1; IFNA12
Hepatitis B
IFNA21; YWHAZ; FASLG; Fasl; PIK3R5; ATP6AP1; DDX3X; IFNB1; STAT3; MAP2K1
Measles
DDX58; FAS; STAT5B; PIK3CA; CD3E; CD3D; CBLB; DOK1; OAS1B; HSPA1L; STAT3
Influenza A
IFNA13; PIK3R5; IFNA12; CXCL10; IFIH1; PRSS2; IFNA2; CPSF4; XPO1; NXT2
Herpes simplex infection
TBPL2; SRSF5B; Hc; STAT2; CLOCKB; TNFB; IFNGR2; CSNK2A2A; HLA-DPA1; PKZ

Protein Function

IFIH1 has several biochemical functions, for example, ATP binding, DNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFIH1 itself. We selected most functions IFIH1 had, and list some proteins which have the same functions with IFIH1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAPK14B; PTK7A; BMPR2; ITPK1; GSK3A; DDX43; ATP6V1BA; MCM3; MYO10; ATP2B1
Function DNA binding
Related Protein BACH1A; ZNF574; TOP1; NR1H5; TIGD5; TCEB3C; ASCL1; DEAF1; EEPD1; TBX10
Function double-stranded RNA binding
Related Protein ILF2; DHX36; RNASEN; MYH4; LSM14A; MSN; MTDH; DROSHA; STAU1; DICER1
Function helicase activity
Related Protein HELQ; HLTF; CHD6; DHX34; BAT1; EP400; DHX36; EIF4A1; DDX52; DHX57
Function protein binding
Related Protein PSMD2; MICA; NOC2L; GPATCH4; AP2B1; TXLNB; MED30; CSPG5; PPP3R2; PCSK9
Function ribonucleoprotein complex binding
Related Protein CD2BP2; PPIH; RNASEL; BOP1; PRMT7; ITCH; PIGC; PRPF6; SECISBP2; CKAP5
Function single-stranded RNA binding
Related Protein TLR8; DDX58; POLR2G; CBX7; NXF1; LONP1; CBX4; LSM14A; AGO2; AGO3
Function zinc ion binding
Related Protein BBOX1; ZDHHC3B; TRIM3; RBM5; FNTB; ZFAND5A; CPXM1; MEP1A.1; DDX41; RNF213

Interacting Protein

IFIH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFIH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFIH1.
MAVS; US11; DDX3X; P/V/C; P/V; P/V; P/V; P/V/C; P/V/C; P/V

IFIH1 Related Articles

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).

IFIH1 Related Gene Family

Cytokines