ING2
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Official Full Name
inhibitor of growth family, member 2
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Overview
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. -
Synonyms
ING2; inhibitor of growth family, member 2; ING1L, inhibitor of growth family, member 1 like; inhibitor of growth protein 2; p33ING2; p32; ING1Lp; inhibitor of growth 1-like protein; ING1L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ING2 Related Articles
- ING2 Related Research Area
ING2 involved in several pathways and played different roles in them. We selected most pathways ING2 participated on our site, such as Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Senescence and Autophagy | IGFBP7;FKBP8;AMBRA1;IFI16;RB1CC1;GABARAP;ING1;MAP1LC3B;RSL1D1 |
ING2 has several biochemical functions, for example, DNA binding, chromatin binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING2 itself. We selected most functions ING2 had, and list some proteins which have the same functions with ING2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | APEX2;LBX1B;ZKSCAN14;OTPB;RX1;NFAT5A;BANF1;ZNF37A;VOX |
| chromatin binding | MSL1;CSNK2B;CRTC2;SMAD2;TPR;SMAD6;ARID3A;NEUROG1;OST4 |
| methylated histone binding | CHD1;WDR92;GLYR1;ING1;SPIN1;MTF2;LRWD1;L3MBTL1;MPHOSPH8 |
| phosphatidylinositol binding | SNX7;SNX17;SNX22;SNX10A;RPS6KC1;MYO1E;SNX18A;TUB;SNX27A |
| protein binding | ING5;RBBP4;SLC4A1;IL1RL1;MC5R;PAK1;TXNL4A;CPSF6;LPL |
| protein complex binding | PAFAH1B1;Apba1;NFYB;WRN;CAV3;KHDRBS1;GNB4;LCA5;ATM |
| zinc ion binding | TK1;SIRT5;TRIM109;BTR18;ZCCHC7;SRSF7A;ABLIM1B;GM3258;MT1M |
ING2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING2.
PCNA; SMURF1; h3; TP53; UBC; SUMO1; H3F3A; EP300; SIN3A; SMURF1; h3_peptide_2-18; ostp_human_gene; tmm71_human_gene; SAP30; HDAC1
- Q&As
- Reviews
Q&As (7)
Ask a questionChronic AngⅡ infusion increased myocardial expression levels of Ac-p53(Lys382) and p-p53(Ser15), and Ing2 silencing prior to AngⅡ infusion reduced the increase in Ac-p53(Lys382) without affecting p53(Ser15) expression.
Ing2 mRNA and protein levels were significantly higher in mice with chronic Ang Ⅱ infusion compared to saline-infused mice.
The conclusion is that Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.
Ing2 silencing significantly alleviated AngⅡ-induced cardiac function decline, as evidenced by reduced LVEDD and LVESD and increased LVEF and LVFS.
The study suggests that the reduction of p53 acetylation by Ing2 silencing contributes to the prevention of cardiac remodeling and dysfunction in response to chronic AngⅡ infusion.
Chronic AngⅡ infusion led to increased left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and reduced left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) in the mice.
Ing2 silencing improved myocardial mitochondrial damage, reduced myocardial hypertrophy and fibrosis, and inhibited cardiomyocyte apoptosis induced by chronic AngⅡ infusion.
Customer Reviews (3)
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Consistently achieving specific outcomes validated the pivotal role of the product in our research studies.
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