ing2
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  • Official Full Name
  • inhibitor of growth family, member 2
  • Background
  • This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.
  • Synonyms
  • ING2; inhibitor of growth family, member 2; ING1L, inhibitor of growth family, member 1 like; inhibitor of growth protein 2; p33ING2; p32; ING1Lp; inhibitor of growth 1-like protein; ING1L
Cat.#:ING2-5130HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ING2 Protein, GST-tagged
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Cat.#:ING2-28777THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ING2
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Cat.#:ING2-308HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human inhibitor of growth family, member 2, His-tagged
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Cat.#:ING2-8208MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ING2 Protein
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Cat.#:ING2-2269RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ING2 Protein, His-tagged
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Cat.#:ING2-580ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ING2
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Cat.#:ING2-5208HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ING2 293 Cell Lysate
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Involved Pathway

ING2 involved in several pathways and played different roles in them. We selected most pathways ING2 participated on our site, such as Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Senescence and Autophagy
COL10A1; ING1; GABARAPL2; IGFBP7; LC3; ATG7; UVRAG; RSL1D1; SLC39A3; IGFBP5

Protein Function

ING2 has several biochemical functions, for example, DNA binding, chromatin binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING2 itself. We selected most functions ING2 had, and list some proteins which have the same functions with ING2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein CBFB; HOXC12; HLX1; DNASE1L3; HOXD3A; ARID4A; TLR8; GIN1; FOXG1D; DICER1
Function chromatin binding
Related Protein MORF4L1; MLL1; MEIS1; RNF20; SKIL; NCOA2; HMGN5; NCOA1; ASCL1; HDAC7A
Function methylated histone binding
Related Protein ATRX; PHF19; WDR92; MPHOSPH8; MSH6; CBX7; CAPNS2; PHF2; KAT8; ZMYND11
Function phosphatidylinositol binding
Related Protein SNX16; TUB; NCF1; SEPT12; SH3YL1; SNX9A; NOXO1; CCDC88A; SNX6; SNX8
Function protein binding
Related Protein POU2AF1; ZNF397; DUSP1; SETDB2; LCORL; ZNF32; SEPT12; MAP1B; RASL11A; HSF2
Function protein complex binding
Related Protein PTPRF; CRIPT; GNB1; SREBF1; RANBP2; RBX1; CDK5RAP1; PFKP; RARB; TELO2
Function zinc ion binding
Related Protein PDLIM3A; BTR02; ADAM17A; ADAMTS3; RNF114; ZBTB32; TRIM46B; TRIM48; NBR1; MLLT6

Interacting Protein

ING2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING2.
PCNA; SMURF1; h3; TP53; UBC; SUMO1; H3F3A; EP300; SIN3A; SMURF1; h3_peptide_2-18; ostp_human_gene; tmm71_human_gene; SAP30; HDAC1

ING2 Related Articles

Su, ZL; Boersma, MD; et al. ChIP-less analysis of chromatin states. EPIGENETICS & CHROMATIN 7:-(2014).
Garske, AL; Oliver, SS; et al. Combinatorial profiling of chromatin binding modules reveals multisite discrimination. NATURE CHEMICAL BIOLOGY 6:283-290(2010).
Jager, D; Stockert, E; et al. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: Characterization of tissue-specific ING1 transcripts and a homologue gene. CANCER RESEARCH 59:6197-6204(1999).