Recombinant Human ING2 Protein, GST-tagged
Cat.No. : | ING2-5130H |
Product Overview : | Human ING2 full-length ORF ( AAH30128, 1 a.a. - 280 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 56.54 kDa |
AA Sequence : | MLGQQQQQLYSSAALLTGERSRLLT CYVQDYLECVESLPHDMQRNVSVLR ELDNKYQETLKEIDDVYEKYKKEDD LNQKKRLQQLLQRALINSQELGDEK IQIVTQMLELVENRARQMELHSQCF QDPAESERASDKAKMDSSQPERSSR RPRRQRTSESRDLCHMANGIEDCDD QPPKEKKSKSAKKKKRSKAKQEREA SPVEFAIDPNEPTYCLCNQVSYGEM IGCDNEQCPIEWFHFSCVSLTYKPK GKWYCPKCRGDNEKTMGKSTEKTKK DRRSR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Publication : |
Protocol for determining the regulation of lipid kinases and changes in phospholipids in vitro (2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner (2021)
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Gene Name : | ING2 inhibitor of growth family, member 2 [ Homo sapiens ] |
Official Symbol : | ING2 |
Synonyms : | ING2; inhibitor of growth family, member 2; ING1L, inhibitor of growth family, member 1 like; inhibitor of growth protein 2; p33ING2; p32; ING1Lp; inhibitor of growth 1-like protein; ING1L; |
Gene ID : | 3622 |
mRNA Refseq : | NM_001564 |
Protein Refseq : | NP_001555 |
MIM : | 604215 |
UniProt ID : | Q9H160 |
Products Types
◆ Recombinant Protein | ||
ING2-4543M | Recombinant Mouse ING2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ing2-3536M | Recombinant Mouse Ing2 Protein, Myc/DDK-tagged | +Inquiry |
ING2-2090R | Recombinant Rhesus Macaque ING2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING2-8208M | Recombinant Mouse ING2 Protein | +Inquiry |
ING2-580Z | Recombinant Zebrafish ING2 | +Inquiry |
◆ Lysates | ||
ING2-5208HCL | Recombinant Human ING2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionChronic AngⅡ infusion increased myocardial expression levels of Ac-p53(Lys382) and p-p53(Ser15), and Ing2 silencing prior to AngⅡ infusion reduced the increase in Ac-p53(Lys382) without affecting p53(Ser15) expression.
Ing2 mRNA and protein levels were significantly higher in mice with chronic Ang Ⅱ infusion compared to saline-infused mice.
The conclusion is that Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.
Ing2 silencing significantly alleviated AngⅡ-induced cardiac function decline, as evidenced by reduced LVEDD and LVESD and increased LVEF and LVFS.
The study suggests that the reduction of p53 acetylation by Ing2 silencing contributes to the prevention of cardiac remodeling and dysfunction in response to chronic AngⅡ infusion.
Chronic AngⅡ infusion led to increased left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and reduced left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) in the mice.
Ing2 silencing improved myocardial mitochondrial damage, reduced myocardial hypertrophy and fibrosis, and inhibited cardiomyocyte apoptosis induced by chronic AngⅡ infusion.
Customer Reviews (3)
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Consistently achieving specific outcomes validated the pivotal role of the product in our research studies.
The product's unique attributes propelled our research to innovative heights.
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