iqcb1
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  • Official Full Name
  • IQ motif containing B1
  • Background
  • This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • IQCB1; IQ motif containing B1; IQ calmodulin binding motif containing 1; IQ calmodulin-binding motif-containing protein 1; KIAA0036; nephrocystin 5; NPHP5; IQ calmodulin binding motif containing protein 1; IQ calmodulin-binding motif containing 1; p53 and DNA damage-regulated IQ motif protein; PIQ; SLSN5
Cat.#:IQCB1-5071HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IQCB1 Protein, GST-tagged
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Cat.#:IQCB1-8271MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IQCB1 Protein
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Cat.#:IQCB1-1911ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IQCB1
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Cat.#:IQCB1-868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IQCB1 cell lysate
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Involved Pathway

IQCB1 involved in several pathways and played different roles in them. We selected most pathways IQCB1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with IQCB1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
TMEM67; CEP63; CCP110; DCTN1A; NEDD1; NPHP1; CKAP5; PCM1; CCDC123; CEP97
Assembly of the primary cilium
CSNK1D; IFT43; CEP72; TTC21B; SETD6; RPGRIP1L; DYF-1; CCT2; CEP135; TTC30A1
Organelle biogenesis and maintenance
MRPL52; MRPL38; BBS13; CEP97; EXOC5; IFT43; BBS12; POLRMT; C11orf60; MRPS35

Protein Function

IQCB1 has several biochemical functions, for example, calmodulin binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IQCB1 itself. We selected most functions IQCB1 had, and list some proteins which have the same functions with IQCB1. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein ARPP21; MYO9B; RASGRF2; GM101; ATP2B1; MTAP6; ASPM; PHKA1; ADD3; MYH4
Function enzyme binding
Related Protein MSH2; CTNNB1; ZNF346; LUC7L2; SIRT1; CYP2A6; PCCA; GSTM1; CNTNAP2; EHHADH
Function protein binding
Related Protein UBE2U; PIAS3; CTLA4; BMP1; RBM12B; PAAF1; CAPN2; S100A9; EIF2B2; WASH1

Interacting Protein

IQCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IQCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IQCB1.
CALM1; parE; PCP4L1; b4drt3_human; Cep290; MYO1C; CDIPT; CPLX1; PSMA7; GEMIN2; SEC16A; CEP290; ERC2; ANGPT2; IRAK2; XPOT; CALU; GPC4; DDAH1

IQCB1 Related Articles

Coppieters, F; Van Schil, K; et al. Identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveals unusual clinical and molecular findings in retinal dystrophy. GENETICS IN MEDICINE 16:671-680(2014).
de Miguel, FJ; Sharma, RD; et al. Identification of Alternative Splicing Events Regulated by the Oncogenic Factor SRSF1 in Lung Cancer. CANCER RESEARCH 74:1105-1115(2014).