ITGA3 Protein, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)


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Official Full Name integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Background The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Synonyms ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); antigen identified by monoclonal J143 , MSK18; integrin alpha-3; CD49c; GAP B3; VCA 2; VLA3a; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal J143; very late activation protein 3 receptor, alpha-3 subunit; VL3A; GAPB3; MSK18; VCA-2; GAP-B3; FLJ34631; FLJ34704
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA3-5134HCL Recombinant Human ITGA3 293 Cell Lysate HEK293 N/A
    Mouse Itga3-6773M Recombinant Mouse Itga3 protein, His & T7-tagged E.coli His/T7
    Mouse ITGA3-8349M Recombinant Mouse ITGA3 Protein Mammalian Cell His
    Chicken ITGA3-5722C Recombinant Chicken ITGA3 Mammalian Cell His

    ITGA3 involved in several pathways and played different roles in them. We selected most pathways ITGA3 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway ITGB7; FGF17; PKN2; KRAS; THBS1; TEK; ITGB6; AKT2; PHLPP1; PTEN
    Focal adhesion ITGA11A; ITGB6; MET; IGF1RA; ITGB1; CCND1; MYL2B; COL2A1A; COL6A6; VEGFAB
    ECM-receptor interaction TNXB; COL6A5; VWF; Npnt; HMMR; LAMA4; THBS3; COL6A1; CD36; LAMC1
    Hematopoietic cell lineage CD1D; CD8B; ITGA6; ANPEP; FLT3LG; THPO; CD1D2; CR2; Kitl; IL1B
    Regulation of actin cytoskeleton RASSF7; RAC1; ACTN3A; MYLPF; FGF1B; PPP1R12A; PIP5K1A; PIP4K2B; PAK6; GSNA
    Pathways in cancer BIRC5; PLCG2; FGF9; LEF1; PLD1; WNT10B; CCND1; TGFBR2; GNG12; Ar
    Small cell lung cancer BIRC7; PIK3R5; LAMA4; TRAF5; SKP2; LAMB1; BIRC2; AKT1; APAF1; PTGS2
    Hypertrophic cardiomyopathy (HCM) CACNG7; ACTC1; CACNA2D3; CACNA2D4; ACE; ITGB4; ITGB5; ITGA6; CACNA2D2; ITGA9
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CDH2; CTNNA3; CACNG1; CACNA2D3; ITGAV; CACNB3; ITGB1; CACNB4; ACTN1; Itga10&Itgb1
    Dilated cardiomyopathy PRKACA; CACNA2D4; PRKACG; TPM1; CACNA2D2; ITGB7; DAG1; TNNC1; CACNG3; EMD

    ITGA3 has several biochemical functions, for example, collagen binding, fibronectin binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA3 itself. We selected most functions ITGA3 had, and list some proteins which have the same functions with ITGA3. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding COMP; MMP9; MTAP1A; HSD17B12; CTSK; RELL2; ITGA9; SMAD4; GPR56; ITGA10
    fibronectin binding MMP13; VEGFA; IGFBP5B; LPA; ITGB1; ITGA3; ITGB3; IGFBP5; ITGAV; SDC4
    glycoprotein binding SDCBP; LDLR; ERLEC1; CD4; SERPINA1D; DNAJC5; CNTN1; CNTN2; FOXRED2; IDE
    integrin binding COL3A1; ESM1; DST; ADAM15; ICAM1; ADAM10; WISP3; WISP1; ICAM4; EMP2
    laminin binding TINAGL1; LRRC15; ITGB1; RPSA; BCAM; ADAM9; NCL; LYPD5; AGRN; GPC1
    metal ion binding HENMT1; CMTM2A; ZC3H18; ZRANB1B; ZNF865; DDHD1; MOXD1L; RRM2B; CYP2B19; CMC1
    protease binding FLOT1; TIMP2A; BCL10; CCBE1; SERPINA5; ALPI; Cstb; ADAMTSL4; LRP1; TP53
    protein binding NLRP2; SNCAIP; MACROD1; GSTK1; PPP3R1; RAC3; NAPRT1; IL11; RAB8B; LEPR
    protein domain specific binding YWHAE1; XPO1; YWHAQ; RAN; POU2F2; TACC3; HIST4H4; RAB27A; RUNX2; YWHAZ
    protein heterodimerization activity P4HB; TAF9B; THRA; TTR; SOX14; TAF4B; BCL2A1; MEF2C; PKNOX1; DLG4B

    ITGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA3.

    PDIA3; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; gd3; cona_canen; Itgb1

    Bauer, KM; Watts, TN; et al. Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3. JOURNAL OF PROTEOME RESEARCH 13:4910-4918(2014).
    Ren, Y; Hao, PL; et al. Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431. MOLECULAR & CELLULAR PROTEOMICS 13:3126-3137(2014).

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