ITGA3
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Official Full Name
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -
Overview
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
ITGA3;integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor);antigen identified by monoclonal J143 , MSK18;integrin alpha-3;CD49c;GAP B3;VCA 2;VLA3a;FRP-2;galactoprotein B3;VLA-3 subunit alpha;CD49 antigen-like family member C;antigen identified by monoclonal J143;very late activation protein 3 receptor, alpha-3 subunit;VL3A;GAPB3;MSK18;VCA-2;GAP-B3;FLJ34631;FLJ34704
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ITGA3 involved in several pathways and played different roles in them. We selected most pathways ITGA3 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PRKAA1,FGF10,PPP2R2D,LPAR6,LAMA2,SYK,IFNA2,YWHAH,IL2RG,PIK3R2 |
| Small cell lung cancer | TRAF4,LAMB4,PIK3R2,IKBKG,AKT2,NFKB1,COL4A1,PIAS2,ITGA2,BCL2 |
| Pathways in cancer | ARNT,MAPK1,WNT5B,GSK3B,PRKACG,NKX3,LAMA1,XIAP,CASP9,RXRB |
| Regulation of Actin Cytoskeleton | RRAS,FGFR3,FGF13B,ITGAV,VCL,SSH3,MYH10,PXN,ITGB7,ARHGEF7 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA9,EMD,ITGAV,ITGB1,CACNG6,ITGB5,CACNA2D4,ACTN3,ITGB4,CTNNA1 |
| Hypertrophic cardiomyopathy (HCM) | ITGA5,ITGB5,ITGA10,DES,SGCB,CACNA2D3,CACNG1,TGFB1,ITGA1,ACTC1 |
| Focal adhesion | KDR,ACTG1,TNXB,COL27A1,MYLPF,PDGFC,HRASB,MAPK1,ITGA11A,PTK6 |
| ECM-receptor interaction | VTNB,FN1A,COL24A1,ITGB7,ITGA2B,FN1,VTNA,IBSP,COL2A1,ITGA1 |
| Dilated cardiomyopathy | TGFB3,CACNG3,CACNG1,TTN,MYL3,CACNA2D3,DES,ITGA5,SLC8A1,ITGA6 |
Protein Function
ITGA3 has several biochemical functions, for example, collagen binding,fibronectin binding,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA3 itself. We selected most functions ITGA3 had, and list some proteins which have the same functions with ITGA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | UGT1A3,RRAGC,HIST1H4L,HIST1H4C,SNX6,UBA2,SOS1,HIST1H2BL,UGT1A9,MAFA |
| collagen binding | RELL2,SERPINH1A,SPARC,SMAD3,ITGA1,CTSB,PDGFB,LUM,MMP9,COMP |
| fibronectin binding | FBLN1,CCDC80,ITGB1A,HSD17B12,THBS1,ITGB3,ITGAV,ITGA4,MMP13,VEGFA |
| protein binding | ARRB1,GRIK3,PKP1,SMN1,DDR2,ITGB1BP3,INTS10,MAGEH1,ZNF69,HEATR5B |
| laminin binding | BCAM,LYPD3,LGALS2A,AGRN,ITGB1,GPC1,LGALS3,THBS1,RPSA,CTSS |
| metal ion binding | ZFY2,ZFP36L1,CD209C,MBNL2,NUDT8,LATS2,ZNF791,ENDOG,PPARDB,PRKCBA |
| protein domain specific binding | YWHAQA,DVL2,ATN1,COX4I2,YWHAQB,HIST2H4A,FOXA1,ACSL3,HIST1H4J,RUNX2 |
| protease binding | C10orf2,ADAM8A,ADAMTSL4,F3,HSPD1,SEMG2,PINK1,ELANE,FLOT2,TRIP4 |
| integrin binding | LAMB2,LAMB1,ICAM3,ILK,ITGB1BP2,ADAM22,WISP1B,ESM1,ADAM10,THBS4 |
Interacting Protein
ITGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA3.
PDIA3;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;gd3;cona_canen;Itgb1
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References
- Bauer, KM; Watts, TN; et al. Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3. JOURNAL OF PROTEOME RESEARCH 13:4910-4918(2014).
- Ren, Y; Hao, PL; et al. Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431. MOLECULAR & CELLULAR PROTEOMICS 13:3126-3137(2014).
