itga3
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  • Official Full Name
  • integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
  • Background
  • The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); antigen identified by monoclonal J143 , MSK18; integrin alpha-3; CD49c; GAP B3; VCA 2; VLA3a; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal J143; very late activation protein 3 receptor, alpha-3 subunit; VL3A; GAPB3; MSK18; VCA-2; GAP-B3; FLJ34631; FLJ34704
Cat.#:Itga3-6773MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itga3 protein, His & T7-tagged
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Cat.#:ITGA3-8349MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGA3 Protein
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Cat.#:ITGA3-5722CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGA3
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Cat.#:ITGA3-5134HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGA3 293 Cell Lysate
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Involved Pathway

ITGA3 involved in several pathways and played different roles in them. We selected most pathways ITGA3 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
IL4R; GNB4; TNXB; Ifna11; GH2; TEK; YWHAH; THBS4; LPAR5; PPP2R3A
Focal adhesion
MAPK6; SPP1; COL2A1; AKT2L; COL6A6; CAV3; GSK3AA; PARVB; ACTN2; MYLPF
ECM-receptor interaction
COL5A1; SV2B; LAMB1; GP1BB; COL11A2; ITGA1; LAMC3; SDC4; SV2C; IBSP
Hematopoietic cell lineage
IL3RA; ITGB3; ITGA2; FLT3LG; CD3D; MME; HLA-DRB5; GM-CSF; CD5; CD1C
Regulation of actin cytoskeleton
PFN4; PIK3R2; APC2; WASF1; RHOAC; ACTN2; Pdgfa&Pdgfb; PDGFB; ACTN1; PDGFAA
Pathways in cancer
GNG2; FGF6; PIK3CG; FZD6; TGFB3; NRAS; PRKACG; Pdgfa&Pdgfb; APC2; VHL
Small cell lung cancer
LAMA3; TRAF6; LAMA2; ITGA3; BIRC2; BIRC7; LAMB1; BCL2L1; TRAF1; CYCS
Hypertrophic cardiomyopathy (HCM)
MYL3; CACNB2; PRKAB1; ITGB3; ITGB4; DAG1; MYL2; TGFB3; CACNA2D3; CACNB3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
TCF7L2; SGCD; ITGB4; CACNB2; ITGAV; ITGB3; ACTN4; CACNG8; GJA1; SGCG
Dilated cardiomyopathy
TNNC1; DMD; CACNG2; IGF1; EMD; TPM3; Adcy4; TPM2; SGCG; LAMA2

Protein Function

ITGA3 has several biochemical functions, for example, collagen binding, fibronectin binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA3 itself. We selected most functions ITGA3 had, and list some proteins which have the same functions with ITGA3. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein LUM; TGFBI; TLL1; USH2A; PODN; MMP13; DDR1; CTSK; RELL2; PDGFA
Function fibronectin binding
Related Protein SFRP2; CTSL1; ITGB1; ITGB3; CTSS; MFAP2; CTSK; FSTL3; ITGA4; IGFBP5A
Function glycoprotein binding
Related Protein TFR2; FOXRED2; FYN; EDEM1; FBXO6; BBC3; HFE2; OS9; LRRK2; F7
Function integrin binding
Related Protein ECM2; TGFBI; THY1; CYR61L1; ACTN4; ADAM23; ADAM17; NISCH; CD226; ICAM4
Function laminin binding
Related Protein ITGA7; ITGA3; AGRN; PLEKHA2; LGALS2A; ECM1; RPSA; CTSS; LYPD3; BCAM
Function metal ion binding
Related Protein ZNHIT1; PVALB8; KLF5; TGM5; PPM1G; TRIM35-19; DGKE; ALOX8; SNAI1B; ZNF740
Function protease binding
Related Protein ITGB3; SERPINA1E; Casp3; RFFL; FURIN; NFRKB; SERPINB9; MALT1; SERPINE1; PEO1
Function protein binding
Related Protein WIPF1; CCDC50; RARS; C14orf93; TBC1D9B; FAM110C; LIMD2; UBE2B; RBM6; TRIM32
Function protein domain specific binding
Related Protein STMN3; POU2F2; MRPS31; YWHAG; HIST1H4L; HIST1H4K; YWHAQB; RAPGEF3; MPP5; HOXB1
Function protein heterodimerization activity
Related Protein TAF6L; ALG2; HIST1H4K; TBX15; HIST1H4E; UGT1A7; PKNOX1; TAF8; DRD1; TPD52L1

Interacting Protein

ITGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA3.
PDIA3; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; gd3; cona_canen; Itgb1

ITGA3 Related Articles

Bauer, KM; Watts, TN; et al. Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3. JOURNAL OF PROTEOME RESEARCH 13:4910-4918(2014).
Ren, Y; Hao, PL; et al. Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431. MOLECULAR & CELLULAR PROTEOMICS 13:3126-3137(2014).