Recombinant Full Length Human ITGA3 Protein, C-Flag-tagged

• Cat.No.: ITGA3-1011HFL
• Product Overview: Recombinant Full Length Human ITGA3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 115.6 kDa
• AA Sequence: MGPGPSRAPRAPRLMLCALALMVAA GGCVVSAFNLDTRFLVVKEAGNPGS LFGYSVALHRQTERQQRYLL LAGAPRELAVPDGYTNRTGAVYLCP LTAHKDDCERMNITVKNDPGHHIIE DMWLGVTVASQGPAGRVLVC AHRYTQVLWSGSEDQRRMVGKCYVR GNDLELDSSDDWQTYHNEMCNSNTD YLETGMCQLGTSGGFTQNTV YFGAPGAYNWKGNSYMIQRKEWDLS EYSYKDPEDQGNLYIGYTMQVGSFI LHPKNITIVTGAPRHRHMGA VFLLSQEAGGDLRRRQVLEGSQVGA YFGSAIALADLNNDGWQDLLVGAPY YFERKEEVGGAIYVFMNQAG TSFPAHPSLLLHGPSGSAFGLSVAS IGDINQDGFQDIAVGAPFEGLGKVY IYHSSSKGLLRQPQQVIHGE KLGLPGLATFGYSLSGQMDVDENFY PDLLVGSLSDHIVLLRARPVINIVH KTLVPRPAVLDPALCTATSC VQVELCFAYNQSAGNPNYRRNITLA YTLEADRDRRPPRLRFAGSESAVFH GFFSMPEMRCQKLELLLMDN LRDKLRPIIISMNYSLPLRMPDRPR LGLRSLDAYPILNQAQALENHTEVQ FQKECGPDNKCESNLQMRAA FVSEQQQKLSRLQYSRDVRKLLLSI NVTNTRTSERSGEDAHEALLTLVVP PALLLSSVRPPGACQANETI FCELGNPFKRNQRMELLITFEVIGV TLHTRDLQVQLQLSTSSHQDNLWPM ILTLLVDYTLQTSLSMVNHR LQSFFGGTVMGESGMKTVEDVGSPL KYEFQVGPMGEGLVGLGTLVLGLEW PYEVSNGKWLLYPTEITVHG NGSWPCRPPGDLINPLNLTLSDPGD RPSSPQRRRRQLDPGGGQGPPPVTL AAAKKAKSETVLTCATGRAH CVWLECPIPDAPVVTNVTVKARVWN STFIEDYRDFDRVRVNGWATLFLRT SIPTINMENKTTWFSVDIDS ELVEELPAEIELWLVLVAVGAGLLL LGLIILLLWKCDFFKRTRYYQIMPK YHAVRIREEERYPPPGSTLP
  TKKHWVTSWQTRDQYYTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

Gene Information

• Gene Name: ITGA3 integrin subunit alpha 3 [ Homo sapiens (human) ]
• Official Symbol: ITGA3
• Synonyms: JEB7; VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
• Gene ID: 3675
• mRNA Refseq: NM_002204.4
• Protein Refseq: NP_002195.1
• MIM: 605025
• UniProt ID: P26006