itgam
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  • Official Full Name
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • Background
  • This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit
Cat.#:ITGAM-2649HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAM Protein, MYC/DDK-tagged
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Cat.#:ITGAM&ITGB2-692HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGAM&ITGB2
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Cat.#:ITGAM-1798HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGAM protein, His & GST-tagged
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Cat.#:ITGAM-1799HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGAM protein, His-tagged
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Cat.#:ITGAM-231HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGAM, GST-tagged
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Cat.#:ITGAM-28HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAM protein, His-tagged
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Cat.#:ITGAM-4257HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)
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Cat.#:Itgam&Itgb2-605MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Itgam&Itgb2
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Cat.#:Itgam-1800MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgam protein, His-tagged
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Cat.#:Itgam-1801RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itgam protein, His-tagged
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Cat.#:Itgam-1802RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itgam protein, His-tagged
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Cat.#:CDA082PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-11b
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Involved Pathway

ITGAM involved in several pathways and played different roles in them. We selected most pathways ITGAM participated on our site, such as Rap signaling pathway, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
LAT; PIK3R5; FGF20; MET; RAP1GAP; CALM3; ANGPT4; BRAF; MAP2K6; ITGA2B
Phagosome
CCDC102A; HLA-DMB; SEC22BB; ITGB2L; DYNC1I1; FCGR2A; SFTPD; HLA-A; ACTB2; M6PR
Cell adhesion molecules (CAMs)
CADM1; HLA-DMA; NCAM2; ITGA6B; NTNG1; SDC2; CLDN10; CD226; CADM1B; ITGAL
Hematopoietic cell lineage
FCGR1A; ITGA6; CD9; Flt3l; CD14; IL5; IL1R2; CD22; MS4A1; IL1A
Leukocyte transendothelial migration
ROCK1; PRKCB; CYBA; TXK; RHOH; MAPK13; VCL; OCLN; MYL5; VASP
Regulation of actin cytoskeleton
ITGB8; ARHGEF12; RAC1A; ROCK1; FGF16; MYL12.1; NRAS; MYLK; VAV3B; GSNA
Pertussis
NOS2; IL12A; IL-8; TNF; NLRP3; C1QA; CALM2; CASP1; IL6; C1QC
Legionellosis
CXCL1; CASP1; TLR5; NLRC4; APAF1; IL-8; SAR1A; IL1B; HSPA8; NFKB2
Leishmaniasis
MAPK12; HLA-DRA; TRAF6; C3; HLA-DRB3; NFKBIB; TGFB3; FCGR3B; TLR2; MAPK13
Amoebiasis
Itgam&Itgb2; MUC2; COL4A3; GNAL; TGFB2; PIK3R1; GNA11; TLR2; TGFB3; AASS
Staphylococcus aureus infection
C3AR1; CFB; HLA-DOA; CFI; SELP; C1QC; FCGR4; MBL1; FCGR1A; Hc
Tuberculosis
NFYB; ITGAM; NFYA; HLA-DQB1; CAP18; ARHGEF12; IFNA1; FCGR2B; CAMK2A; MAPK12
Transcriptional misregulation in cancer
IGF1R; MEIS1; TLX3; TMPRSS2; HOXA10; FLT1; MEF2C; SPI1; ZBTB17; PBX1

Protein Function

ITGAM has several biochemical functions, for example, glycoprotein binding, heparan sulfate proteoglycan binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAM itself. We selected most functions ITGAM had, and list some proteins which have the same functions with ITGAM. You can find most of the proteins on our site.
Function
Related Protein
Function glycoprotein binding
Related Protein FBXO17; HFE2; TFR2; CNTN2; TFRC; SERPINA1E; PTBP3; CANX; CSNK1D; RASA1
Function heparan sulfate proteoglycan binding
Related Protein HRG; HPSE2; GPC1B; AZU1; COMP; SEMA5A; PLA2G2D; Gpc2; GPC5; GPC5A
Function heparin binding
Related Protein FGF1; CCL5; KAL1; CCL23; CFH; FGFBP3; SELP; LIPH; APOA5; WISP3
Function metal ion binding
Related Protein NDUFV1; PRDM13; FOXP2; FHL1A; ZFP551; HMOX2; ZSCAN5A; TSSK1; CD209; GATA5
Function opsonin binding
Related Protein CLEC7A; Itgam&Itgb2; ITGAM
Function protein binding
Related Protein ZNF83; TAX1BP3; HHLA3; TTK; KLK5; LCAT; RAB32; HYI; EIF3C; ELP4

Interacting Protein

ITGAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAM here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAM.
CLEC4M; fibrinogen_human_complex; crlkekhc

ITGAM Related Articles

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Rosetti, F; Chen, YF; et al. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. CELL REPORTS 10:1655-1664(2015).