Recombinant Mouse Itgam protein, His-tagged

• Cat.No.: Itgam-1800M
• Product Overview: Recombinant Mouse Itgam aa. (Asn248~Gly430 (Accession # P05555)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 22kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Asn248~Gly430 (Accession # P05555)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >98%
• Characteristic: The isoelectric point is 5.7.
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200ug/mL
• Storage buffer: 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
• Reconstitution: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Itgam integrin alpha M [ Mus musculus (house mouse) ]
• Official Symbol: Itgam
• Synonyms: Itgam; integrin alpha M; CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik; integrin alpha-M; CD11 antigen-like family member B; CD11B (p170); CR-3 alpha chain; Mac-1 alpha; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; leukocyte adhesion receptor MO1; macrophage antigen alpha
• Gene ID: 16409
• mRNA Refseq: NM_001082960.1
• Protein Refseq: NP_001076429.1
• UniProt ID: P05555

Reviews

12/10/2022

Reliable data for credibility. Trusted for results.

02/27/2022

Timely and precise results. Accelerates our research timelines.

06/27/2018

Efficient and dependable service. Enhances research quality.

Q&As

How does ITGAM contribute to the adhesion and migration of leukocytes?

It facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.

What potential therapeutic applications arise from targeting ITGAM in immune-related disorders?

Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.

How do genetic variations in ITGAM affect immune responses and susceptibility to autoimmune diseases?

Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.

What role does ITGAM play in the immune system's response to infection?

ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.

How does ITGAM interact with other components of the immune system?

ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.

What is the primary role of ITGAM in immune cell function?

ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.

What is the impact of altered ITGAM activity on inflammatory processes?

Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.