KIF4A

  • Official Full Name

    kinesin family member 4A

  • Overview

    This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.

  • Synonyms

    KIF4A;kinesin family member 4A;chromosome-associated kinesin KIF4A;chromokinesin;FLJ12530;FLJ12655;FLJ14204;FLJ20631;HSA271784;KIF4;KIF4 G1;chromokinesin-A;KIF4G1
Cat.# Product name Source (Host) Species Tag Protein Length Price
KIF4A-375H Recombinant Human KIF4A, GST-tagged E.coli Human GST 1-351aa
KIF4A-6534C Recombinant Chicken KIF4A Mammalian Cells Chicken His
KIF4A-4944HCL Recombinant Human KIF4A 293 Cell Lysate HEK293 Human Non
KIF4A-221HKCL Human KIF4A Knockdown Cell Lysate HeLa Human Non

    Involved Pathway

    KIF4A involved in several pathways and played different roles in them. We selected most pathways KIF4A participated on our site, such as Adaptive Immune System,Axon guidance,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet production MAFF,CABLES1,HBG2,HBB-BH1,DOCK2,AKAP10,HBB-Y,KIF5B,KLC3,HBD
    Kinesins KIF2A,RACGAP1,KIF3B,KIFAP3,KIF2B,KIF15,KIF22,KIF26A,KIF20A,KIF18A
    Adaptive Immune System MAPKAP1,OSBPL1A,TRAF7,CLEC2G,RNF41,RNF182,FRS2B,LILRA2,ASB13,ASB4
    Hemostasis MAFG,KIFC1,SLC3A2B,SERPINA1L,HBG2,MAFGB,LRRC16A,F13A1A.1,AKAP1B,RAPGEF4
    L1CAM interactions DPYSL2,DPYSL2B,CHL1,EZRA,SCN4A,NRP1A,SCN2A,SCN2B,RANBP9,KIF4
    Axon guidance EPHB4,DNM2,EPHB1,NTN4,PITPNA,EFNA2,SEMA5B,COL9A1A,Ntng2,EFNA1A
    Developmental Biology PEA15A,FRS2B,BOC,SPNA1,RHOB,SPRED3,EZRA,WDR83,COL9A1A,EPHB4A
    Immune System RNF19B,Siglece,PVRL2L,CTSD,FCN3,DYNC1I1,SPSB2,DEFB4A,HAVCR2,DYNLL2

    Protein Function

    KIF4A has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF4A itself. We selected most functions KIF4A had, and list some proteins which have the same functions with KIF4A. You can find most of the proteins on our site.

    Function Related Protein
    microtubule motor activity KIF2C,KLC3,APPBP2,DNAHC8,DYNC1I2,KLC1,DYNC1I1,KIFC1,PROL1,DNAIC2
    microtubule binding KIFC2,PRC1,MAP205,GAS2L2,JAKMIP2,FGF13,FAM154A,CAMSAP1A,VAPB,TRPV4
    ATPase activity ABCG2B,WRNIP1,EIF4A1A,ABCG2D,ATAD2,ABCB6A,KIF23,ABCG5,ABCE1,MYO19
    protein binding KPNA4,WDR11,TBC1D14,NKX3,SCARF1,CREB5,HYAL3,ISY1,OPRK1,OS9
    ATP binding MAP3K9,VMHC,NADSYN1,MAT1A,P2RX4B,DAPK2,HK2,DDX55,BMPR1BA,PRKG1A
    DNA binding OTPA,ZBTB5,RPS15,ZBTB18,CALR,RDM1,PBX3B,DHX9,RAD51AP1,HOXA13

    Interacting Protein

    KIF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF4A.

    Kif4;DNPEP;SVIL;pi3p;SNW1;CDC5L;TTF2;PRC1

    Resources

    Gene Families

    References

    • Fouz, N; Amid, A; et al. Gene Expression Analysis in MCF-7 Breast Cancer Cells Treated with Recombinant Bromelain. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:1618-1639(2014).
    • Minakawa, Y; Kasamatsu, A; et al. Kinesin Family member 4A: A Potential Predictor for Progression of Human Oral Cancer. PLOS ONE 8:-(2013).

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