KIF4A

  • Official Full Name

    kinesin family member 4A

  • Overview

    This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.

  • Synonyms

    KIF4A;kinesin family member 4A;chromosome-associated kinesin KIF4A;chromokinesin;FLJ12530;FLJ12655;FLJ14204;FLJ20631;HSA271784;KIF4;KIF4 G1;chromokinesin-A;KIF4G1
Cat.# Product name Source (Host) Species Tag Protein Length Price
KIF4A-375H Recombinant Human KIF4A, GST-tagged E.coli Human GST 1-351aa
KIF4A-6534C Recombinant Chicken KIF4A Mammalian Cells Chicken His
KIF4A-4944HCL Recombinant Human KIF4A 293 Cell Lysate HEK293 Human Non
KIF4A-221HKCL Human KIF4A Knockdown Cell Lysate HeLa Human Non

    Involved Pathway

    KIF4A involved in several pathways and played different roles in them. We selected most pathways KIF4A participated on our site, such as Adaptive Immune System,Axon guidance,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Kinesins KIF2A,KIF2C,KIFC1,KIF15,KIF18A,RACGAP1,KIF4,KIF3B,KIF20A,KIF26A
    L1CAM interactions CNTN6,CD24,DPYSL2B,CHL1,DPYSL2,EZRA,KCNQ3,NRP1A,SDCBP,SCN3B
    Factors involved in megakaryocyte development and platelet production RACGAP1,CABLES1,PHF21A,MFN1,HMG20B,DOCK9,KIF2C,MAFF,KIF20A,SH2B3
    Developmental Biology WDR83,MEF2AA,DPYSL2,NTN1A,CACNG2,NR5A1,CFC1,SALL4,COL4A3,RNF8
    Axon guidance HBEGF,EFNA1A,SEMA6B,SLC14A2,CAP2,SEMA4B,EFNA3,PAQR3B,EPHB4,SCN3B
    Hemostasis MGC173646,MMRN2A,ESAMA,CFHL4,PROCR,KIF9,TREM1,S100A10B,S100A10,GRB14
    Adaptive Immune System CREB1B,DNM2,CLEC2H,KIF22,UBE2F,AP1G1,UBE2U,DNM1,SIGLEC12,FGF10B
    Immune System KLRB1A,CD300LG,HUWE1,FCGR1B,FCN1,IgG3,TRIM8,EDAR,ADAR,SPSB1

    Protein Function

    KIF4A has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF4A itself. We selected most functions KIF4A had, and list some proteins which have the same functions with KIF4A. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity PSMC2,HSPA8,ABCG3,ABCE1,ATAD1B,ERCC3,MYO19,PMS1,HLTF,KIF25
    microtubule motor activity KLC1A,KIF2C,DNAH6,KLC1,DNAI2,KIF25,DNAH11,DYNC1I1,KIF22,KIF27
    microtubule binding APC,SPAST,KIF17,CAMSAP1B,CHP1,KIF19,RGS14,GABARAPA,SERPINB1A,KIF11
    DNA binding H2AFJ,LHX2B,CHD4,Arid4b,TDP2B,PHC2B,MECP2,GM14478,ZNF764,EPAS1B
    ATP binding IP6K2,NME2A,CDK3,PFKFB4L,STK32C,MAP4K2,EPHA4B,ERCC6L2,P2RX4B,SMG1
    protein binding PGR,DCDC2B,TSSK2,LRDD,GYG1,POSTN,COX8A,C20orf195,DNER,PIDD1

    Interacting Protein

    KIF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF4A.

    Kif4;DNPEP;SVIL;pi3p;SNW1;CDC5L;TTF2;PRC1

    Resources

    Gene Families

    References

    • Fouz, N; Amid, A; et al. Gene Expression Analysis in MCF-7 Breast Cancer Cells Treated with Recombinant Bromelain. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:1618-1639(2014).
    • Minakawa, Y; Kasamatsu, A; et al. Kinesin Family member 4A: A Potential Predictor for Progression of Human Oral Cancer. PLOS ONE 8:-(2013).

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