kif5a
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  • Official Full Name
  • kinesin family member 5A
  • Background
  • This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
  • Synonyms
  • KIF5A; kinesin family member 5A; spastic paraplegia 10 (autosomal dominant) , SPG10; kinesin heavy chain isoform 5A; D12S1889; MY050; NKHC; KIF5A variant protein; neuronal kinesin heavy chain; kinesin heavy chain neuron-specific 1; kinesin, heavy chain, n
Cat.#:KIF5A-259HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIF5A Protein, His-tagged
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Cat.#:Kif5a-260MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Kif5a Protein, His/GST-tagged
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Cat.#:Kif5a-261RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Kif5a Protein, His/GST-tagged
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Cat.#:KIF5A-376HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIF5A, GST-tagged
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Cat.#:KIF5A-8647MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KIF5A Protein
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Cat.#:KIF5A-3258RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KIF5A Protein
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Involved Pathway

KIF5A involved in several pathways and played different roles in them. We selected most pathways KIF5A participated on our site, such as Adaptive Immune System, Dopaminergic synapse, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
NRG4; NA; CD200; CTSK; RAET1E; CD300LD; RNF6; UBE2L6; FCGR1B; CTSE
Dopaminergic synapse
AKT2; MAPK8; CREB3L2; GNAO1; PLCB3; CLOCK; MAPK9; MAPK11; PPP2R2B; GRIA3
Endocytosis
CBLB; GIT2; ARPC5L; CCR5; SH3GL3; SMAD3A; AP2M1B; CHMP2BA; SH3GL3B; ZFYVE20
Factors involved in megakaryocyte development and platelet production
KIFC1; HBBE2; DOCK8; DOCK1; CBX5; SH2B3; LRRC16A; PHF21A; H3F3B.1; DOCK6
Hemostasis
FCER1GL; MFN2; TRPC7; SLC3A2A; AMICA1; GNA13B; MFN1; CFHL3; CFHL1; SLC3A2B
Immune System
KIR3DS1; DEFB119; VPRBP; BTR22; LY86; IL1RN; KIF11; UBE2J2; DYNLL2; ASB11
Insulin processing
PCSK2; EXOC1; SLC30A8; EXOC8; PCSK1; RAB27A; KIF5B; SLC30A5; CPN1; CPE
Kinesins
KIF9; RACGAP1; KIF2B; KIF4; KLC3; KIF4A; KIF2C; KIFAP3; KIF11; KIF3B

Protein Function

KIF5A has several biochemical functions, for example, ATP binding, ATP-dependent microtubule motor activity, plus-end-directed, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5A itself. We selected most functions KIF5A had, and list some proteins which have the same functions with KIF5A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SPATA5; BRAF; PAICS; TSSK5; DGUOK; PLK3; DNAJA1; ATP1A3B; MAP3K1; FGFR1A
Function ATP-dependent microtubule motor activity, plus-end-directed
Related Protein KIF3B; KIF5A; KIF14; KIF17; KIF5B; KIF3A; KIF18A; KIF5C; KIF11; KIF5AA
Function microtubule binding
Related Protein GAS2L1; EML1; MTAP1A; CEP57; PSRC1; VAPB; FMR1; KIF4A; MACF1; CRIPT
Function motor activity
Related Protein MYO6; MYL6B; MYO15; DNALC4; MYH8; DYNLT3; MYO1F; MYH9A; KLC1; KIF5A
Function protein binding
Related Protein PNMA5; ZBTB16; EBF2; HM13; H2-KE2; SSX1; COX4I1; RPP30; TRIM26; SHOX

Interacting Protein

KIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5A.
ANKRD27; RXRB; PCBD1; MDM2; Trak2; TRAK1; MAP4K4; TK1; Hap1; PIN1; TP53BP2; ITSN1; SMN1; TRAF3IP1; M

KIF5A Related Articles

Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).
van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).

KIF5A Related Gene Family

Kinesins (KIF)