KIF5B
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Official Full Name
kinesin family member 5B -
Overview
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. -
Synonyms
KIF5B;kinesin family member 5B;KNS;KINH;KNS1;UKHC;HEL-S-61;kinesin-1 heavy chain;kinesin heavy chain;kinesin 1 (110-120kD);ubiquitous kinesin heavy chain;conventional kinesin heavy chain;epididymis secretory protein Li 61
Recombinant Proteins
- Rat
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Avi
- Fc
Involved Pathway
KIF5B involved in several pathways and played different roles in them. We selected most pathways KIF5B participated on our site, such as Adaptive Immune System,Dopaminergic synapse,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | MAP3K9,STXBP3,MYO1C,MINK1,RHOJ,RRAD,FLOT1,EHD1,REG1A,MAPK4 |
| Insulin processing | PCSK1,SLC30A8,CPE,RAB27A,EXOC6,KIF5A,SLC30A5,SLC30A6,EXOC8,EXOC1 |
| Hemostasis | CFD,SLC7A8A,BA1L,ITGB3A,KIF2B,HBBE3,CEACAM6,GATA2A,KIF2C,AASS |
| Adaptive Immune System | PVRL2L,KLB,CD300C,FRS2,SRMS,TRIM63,CTSE,UBE2L6,EGFR,OSBPL1A |
| Factors involved in megakaryocyte development and platelet production | MFN2,DOCK2,GATA2A,KIF2C,MAFG,IRF2A,KDM1A,ZFPM1,KIF26A,H3F3D |
| Dopaminergic synapse | DRD1A,MAPK8,AKT2,GNGT2,CALM4,GNG8,PPP2R5C,SLC18A1,MAPK10,GNAS |
| Endocytosis | HSC70,VPS45,LDLRAP1B,LDLRA,RAB11FIP1,DNM1A,WASH1,ASAP1A,VPS24,RAB31 |
| Immune System | ASB6,GM11711,LRR1,LTF,HBL3,FBXO27,ASB3,IFI35,CLEC5A,UBR2 |
Protein Function
KIF5B has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5B itself. We selected most functions KIF5B had, and list some proteins which have the same functions with KIF5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RAD51D,DHX29,ADCK1,UBE2T,KIF1C,ATP2B3B,SMC4,CDK7,FGFR1,EHD2 |
| microtubule binding | MAPRE1A,DPYSL5B,APC2,HOOK3,VPS41,TRAF3IP1,KIF22,CLIP3,KIF12,ZNF207 |
| protein binding | N4BP2L2,USP2,PDIA6,ARL4D,EIF1AD,PPP2R5B,PAIP1,THAP6,MEF2C,PPP6C |
| microtubule motor activity | KIF25,DYNC1LI1,DNHD1,KIF7,DYNC1H1,DNAIC2,KIF20A,DNAH6,DYNC2H1,KLC4 |
| ATP-dependent microtubule motor activity, plus-end-directed | KIF14,KIF1B,KIF3B,KIF5AA,KIF11,KIF20B,KIF5C,KIF5A,KIF19,KIF3A |
Interacting Protein
KIF5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5B here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5B.
YWHAZ;YWHAQ;YWHAB;YWHAG;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;BCAR3;VDAC1;NME2;SFN;VHL;RANBP2;Hap1
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References
- Hutarew, G; Hauser-Kronberger, C; et al. Immunohistochemistry as a screening tool for ALK rearrangement in NSCLC: evaluation of five different ALK antibody clones and ALK FISH. HISTOPATHOLOGY 65:398-407(2014).
- Go, H; Jung, YJ; et al. Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma. LUNG CANCER 82:44-50(2013).
