KIF7

  • Official Full Name

    kinesin family member 7

  • Overview

    This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

  • Synonyms

    KIF7;kinesin family member 7;kinesin-like protein KIF7;JBTS12;EQYK340;ACLS;HLS2;UNQ340;MGC120653;MGC138476;MGC138478
Cat.# Product name Source (Host) Species Tag Protein Length Price
KIF7-2286Z Recombinant Zebrafish KIF7 Mammalian Cells Zebrafish His
KIF7-8651M Recombinant Mouse KIF7 Protein Mammalian Cells Mouse His
KIF7-4943HCL Recombinant Human KIF7 293 Cell Lysate HEK293 Human Non
KIF7-4822M Recombinant Mouse KIF7 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KIF7-4822M-B Recombinant Mouse KIF7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KIF7 involved in several pathways and played different roles in them. We selected most pathways KIF7 participated on our site, such as Hedgehog off state,Hedgehog on state,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog on state MKS1,KIF3A,EVC2,SPOPL,RPGRIP1L,BOC,IFT172,DZIP1,GPR161,EFCAB7
    Signaling by Hedgehog IFT52,DISP2,CDON,CDC73,EVC2,SPOPL,HHAT,INTU,EFCAB7,GPR161
    Hedgehog off state TTC21B,OFD1,IFT52,WDR35,INTU,GPR161,IFT122,MKS1,WDR19,IFT88
    Signal Transduction FGFBP1,PTHRP2,DLK1,UTS2,GPR37L1,SDR9C7,PCSK6,ARHGAP33,SOX4A,FSTL1A

    Protein Function

    KIF7 has several biochemical functions, for example, ATP binding,ATPase activity,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF7 itself. We selected most functions KIF7 had, and list some proteins which have the same functions with KIF7. You can find most of the proteins on our site.

    Function Related Protein
    microtubule motor activity SMC1A,SMC3,KIF2A,KIFC1,KIF11,KLC4,KLC1B,DYNC1LI1,APPBP2,BBS4
    ATPase activity KIF3CB,ABCA1B,KIF6,MYH7,ABCA9,ABCE1,ATF7IP,ENTPD2,IDE,HSPA5
    microtubule binding PRC1A,GLI1,KIF22,MTAP1A,APC,PAFAH1B1,FAM83D,MAPRE3B,CEP57L1,NDEL1B
    protein binding HSPB1,NCOA3,MFN1,PPCDC,DEPDC1,SFTPC,PEA15,RPS3,AAK1,CHD8
    ATP binding CAMK4,ENTPD3,RECQL4,NRBP2,KIF5A,MAP2K1,SMC6,ENTPD8,STRADB,DDX46

    Interacting Protein

    KIF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF7.

    USP22;EPB41L3;q9wmx2-pro_0000037548;TBC1D31;PCM1;MAP3K4;N4BP3;NRD1;MPZL1;STAMBP;ACTL6A;APC;GMPS;SMTN;HSPG2;PCM1;CCDC18;RAB11FIP2;EMSY

    Resources

    Gene Families

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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