klc3
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  • Official Full Name
  • kinesin light chain 3
  • Background
  • This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.
  • Synonyms
  • KLC3; kinesin light chain 3; KLC2L; KLCt; KNS2B; Kinesin light chain 2; KLC2; KLC2 like; KLC2-like; KLC3_HUMAN
Cat.#:KLC3-1975HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLC3 Protein (1-504 aa), His-SUMO-tagged
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Cat.#:KLC3-1979HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human KLC3 Protein (1-504 aa), His-tagged
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Cat.#:KLC3-8671MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KLC3 Protein
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Cat.#:KLC3-3268RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KLC3 Protein
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Cat.#:KLC3-4631ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KLC3
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Cat.#:KLC3-937HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KLC3 cell lysate
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Involved Pathway

KLC3 involved in several pathways and played different roles in them. We selected most pathways KLC3 participated on our site, such as Adaptive Immune System, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CLEC2G; AP2B1; DCTN3; ASB6; AGO3; HCST; LRR1; UBE2F; TREM1; HUWE1
Factors involved in megakaryocyte development and platelet production
MAFF; GATA1; KIF5B; KIFAP3; H3F3B.1; AKAP1; KIF2C; DOCK1; HBB-BH1; KDM1A
Hemostasis
KIF20A; SLC8A2A; LOC100514666; ITPK1; F9B; BA2; ANXA2; KCNMB1; OSTN; PDPN
Immune System
DEFB104A; GM11711; TXNIP; SH3RF1; UNC93B1; WWP1; LRR1; SEC23A; NLRC5; DYNLL2
Kinesins
KIF4; KLC3; KIF2A; KIF9; KIFAP3; KIF3C; KIF26A; CENPE; KIF18A; KIF2B
MHC class II antigen presentation
DYNC1LI2; MGC174155; KIF22; DCTN6; KIF15; KIFAP3; OSBPL1A; FAM49BA; IFI30; KIF26A
RHO GTPase Effectors
KIF14; NDEL1A; BAIAP2; PRC1B; CDCA8; NF2A; RHPN2; RANGAP1B; RHPN1; RCC2
RHO GTPases activate KTN1
KLC3; KTN1

Protein Function

KLC3 has several biochemical functions, for example, kinesin binding, microtubule binding, microtubule motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLC3 itself. We selected most functions KLC3 had, and list some proteins which have the same functions with KLC3. You can find most of the proteins on our site.
Function
Related Protein
Function kinesin binding
Related Protein ATCAY; KIF18B; PLEKHM2; KIF1B; PPIAL4A; CLSTN1; SYBU; AP1G1; CD36; MAPK8IP3
Function microtubule binding
Related Protein PRC1B; PAFAH1B1A; PAFAH1B1; DPYSL5B; KATNB1; CEP57; KLC3; REEP1; SBDS; TRIM54
Function microtubule motor activity
Related Protein DNAHC8; DNHD1; KLC4; DYNC1I1; KIF5C; SMC1A; KIF2C; KIF2B; KIF3CB; KLC2
Function protein binding
Related Protein DOK6; TOLLIP; TXNRD2; PRMT2; PIBF1; TWF2; ZNF426; ACTG1; SSX2IP; WBP1

Interacting Protein

KLC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLC3.
KRT13; CCDC64B; 147700; NECAB2; NDC80; STX11; TCF4

KLC3 Related Articles

Bhullar, B; Zhang, Y; et al. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. JOURNAL OF BIOLOGICAL CHEMISTRY 278:16159-16168(2003).