KLF2 Protein, Kruppel-like factor 2 (lung)


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Official Full Name Kruppel-like factor 2 (lung)
Background Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell;trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L;(SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).
Synonyms KLF2; Kruppel-like factor 2 (lung); Krueppel-like factor 2; LKLF; KLF 2; KLF2_HUMAN; Kruppel like factor 2; Kruppel like factor; Kruppel like factor LKLF; Lung krueppel like factor; Lung krueppel-like factor; Lung Kruppel like zinc finger transcription factor; Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription factor
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Klf2-1275M Recombinant Mouse Klf2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human KLF2-185H Recombinant Human KLF2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human KLF2-4928H Recombinant Human KLF2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human KLF2-4928HCL Recombinant Human KLF2 293 Cell Lysate HEK293 N/A
    Rat KLF2-3271R Recombinant Rat KLF2 Protein Mammalian Cell His

    KLF2 involved in several pathways and played different roles in them. We selected most pathways KLF2 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PDPK1B; MAPK12B; GRM1; BCL6A; SMAD3; PRKAG2A; FOXO1B; PIK3R2; HRAS; HOMER3

    KLF2 has several biochemical functions, for example, metal ion binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF2 itself. We selected most functions KLF2 had, and list some proteins which have the same functions with KLF2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding PON3; TGM4; ZNF865; ZNF256; NEK3; HBAE1; CYP2K16; KLF2; VPS29; BCL11A
    protein binding IKBKE; HTATIP2; OTUB2; ALDH7A1; PSMB4; TPM1; ZBTB17; FGF1; GTF2B; SETMAR
    sequence-specific DNA binding KLF2; NKX2.4A; ISL1L; LHX2B; HOXA3A; FOXA3; HOXA13A; ATF4B1; Trl; NFE2L2B
    transcription factor activity, sequence-specific DNA binding RARAA; GLI4; SPIB; MAX; GLI3; HIST1H2AH; IRF1B; E2F1; HIVEP2A; RARAB

    KLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF2.


    Ware, CB; Nelson, AM; et al. Derivation of naive human embryonic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4484-4489(2014).
    Allen, KL; Jain, MK; et al. KLF2 and KLF4 Are Essential Mediators of the Anti-Thrombotic Effects of Statins in the Presence of Antiphospholipid/Anti-beta(2)GPI Antibodies. BLOOD 118:1407-1407(2011).

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