lbr
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  • Official Full Name
  • lamin B receptor
  • Background
  • The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LBR; lamin B receptor; PHA; LMN2R; TDRD18; DHCR14B; lamin-B receptor; tudor domain containing 18; integral nuclear envelope inner membrane protein;
Cat.#:LBR-456HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human LBR
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Cat.#:LBR-3362RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LBR Protein
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Cat.#:LBR-2471RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LBR Protein, His-tagged
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Cat.#:LBR-6894CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LBR
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Cat.#:LBR-820ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LBR
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Cat.#:LBR-4811HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LBR 293 Cell Lysate
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Involved Pathway

LBR involved in several pathways and played different roles in them. We selected most pathways LBR participated on our site, such as Cholesterol biosynthesis, Gastric cancer network 2, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LBR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cholesterol biosynthesis
DHCR7; LBR; SREBF2; PMVK; CYP51A1; DHCR24; EBP; ARV1
Gastric cancer network 2
PLAC8; CHTF8; MTDH; CHTF18; DSCC1; TOP2A; RNF144B; ATAD2; LBR; RAD17
Metabolism
GLTP; PDP1; NUDT1; SLC25A16; FABP1B.1; AKR1C4; AGL; DHCR7; CYP2B6; MTP
Metabolism of lipids and lipoproteins
SLC27A5; CERS3B; TIAM2; GLIPR1; MED21; ACOT13; ALOX5AP; FAM213B; CYP2Y3; THEM5
cholesterol biosynthesis I
EBP; LBR; DHCR7; DHCR24
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
EBP; LBR; DHCR24
cholesterol biosynthesis III (via desmosterol)
LBR; EBP
superpathway of cholesterol biosynthesis
LBR

Protein Function

LBR has several biochemical functions, for example, DNA binding, chromo shadow domain binding, lamin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LBR itself. We selected most functions LBR had, and list some proteins which have the same functions with LBR. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP146; PAX8; EGR3; SOX1; POLR3B; ZNF2; HIST3H3; ZBTB5; ZFP11; ZFML
Function chromo shadow domain binding
Related Protein LBR; SP100; TRIM28; CHAF1A; NIPBL; ATRX
Function lamin binding
Related Protein SUN1; TMPO; BNIP3L; IFI27; PKP1; SYNE1; TMEM201; PPP4C; PLCB1; NARF
Function oxidoreductase activity, acting on the CH-CH group of donors
Related Protein TECRL; TECRB; DPYDB; GCDHA; SRD5A2A; COX15; PPP1R2; TECR; TECRL2B; SRD5A3
Function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Related Protein LBR; DHCR24; SRD5A3; TM7SF2; BDH2
Function poly(A) RNA binding
Related Protein RBM34; DHX34; BTF3; DIEXF; DHX57; ADK; PIGC; NOA1; DUS3L; RBM38
Function protein binding
Related Protein CEP70; MS4A1; EMID2; OSBPL3; EIF3F; MTAP; MESDC1; MS4A3; EYA2; XRCC1

Interacting Protein

LBR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LBR here. Most of them are supplied by our site. Hope this information will be useful for your research of LBR.
CBX3; CBX5; YWHAG; SRPK1; 7242199; MYC; YWHAB; PHLDA3; E2F3; ARRB2; CLK3; LRRK2

LBR Related Articles

Goans, RE; Iddins, CJ; et al. APPEARANCE OF PSEUDO-PELGER HUET ANOMALY AFTER ACCIDENTAL EXPOSURE TO IONIZING RADIATION IN VIVO. HEALTH PHYSICS 108:303-307(2015).
Cicinelli, E; Matteo, M; et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. HUMAN REPRODUCTION 30:323-330(2015).