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LCAT

  • Official Full Name

    lecithin-cholesterol acyltransferase

  • Overview

    This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
  • Synonyms

    LCAT; lecithin-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase; LCAT_HUMAN; Lecithin cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phospholipid cholesterol acyltransferase; Phospholipid-cholesterol acyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Flag
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LCAT-7117H Recombinant Human LCAT, His-tagged E.coli His 25-440aa
Human LCAT-1363H Recombinant Human Lecithin-Cholesterol Acyltransferase, Flag-tagged Human Fc
Human LCAT-8326H Recombinant Human LCAT, Flag tagged HEK293 Flag
Human LCAT-526H Recombinant Human LCAT Protein, His-tagged HEK293 His
Human LCAT-1013H Recombinant Human LCAT, Flag-tagged HEK293 Flag
Human LCAT-4809HCL Recombinant Human LCAT 293 Cell Lysate HEK293 N/A
Human LCAT-4421H Recombinant Human LCAT Protein (Phe25-Glu440), C-His tagged Mammalian cells C-His Phe25-Glu440
Human LCAT-5268H Recombinant Human LCAT protein, His-tagged E.coli His 25-433aa
Human LCAT-2380H Recombinant Human LCAT Protein (Phe25-Glu440), His tagged E.coli His Phe25-Glu440
Mouse LCAT-8980M Recombinant Mouse LCAT Protein Mammalian Cell His
Mouse Lcat-600M Recombinant Mouse Lcat protein, His-tagged E.coli His Glu41~His210
Mouse LCAT-5012M-B Recombinant Mouse LCAT Protein Pre-coupled Magnetic Beads HEK293
Mouse Lcat-1676M Recombinant Mouse Lcat protein, His-tagged E.coli His Ile290~Pro432
Mouse LCAT-5012M Recombinant Mouse LCAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Lcat-1677R Recombinant Rat Lcat protein, His-tagged E.coli His Glu41~His210 (Accession # P18424)
Chicken LCAT-5523C Recombinant Chicken LCAT Mammalian Cell His
Kit-0507 LCAT Activity Fluorometric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LCAT Related Articles

LCAT involved in several pathways and played different roles in them. We selected most pathways LCAT participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismGPAT2;EPT1;PLA2G16;AGPAT1;GPD1;AGPAT9;CRLS1;LPCAT4;DGKD

LCAT has several biochemical functions, for example, apolipoprotein A-I binding, phosphatidylcholine-sterol O-acyltransferase activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LCAT itself. We selected most functions LCAT had, and list some proteins which have the same functions with LCAT. You can find most of the proteins on our site.

Function Related Protein
apolipoprotein A-I bindingLCAT;ABCA1;SCARB1;ABCA1B
phosphatidylcholine-sterol O-acyltransferase activity
phospholipase A2 activityPRDX6;PLA2G4AA;OC90;PLA2G16;ABHD3;PNPLA3;PLA2G2F;PLA2G10;PLB1
protein bindingEIF2B1;UBA52;CNIH2;MT2A;FRAS1;TOMM70A;C22orf29;KEAP1;TLR3

LCAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LCAT.

APOA1

Takahashi, S; Hiromura, K; et al. Nephrotic Syndrome Caused by Immune-Mediated Acquired LCAT Deficiency. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 24:1305-1312(2013).
Kwiterovich, PO; et al. Diagnosis and Management of Familial Dyslipoproteinemias. CURRENT CARDIOLOGY REPORTS 15:-(2013).
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