LCAT
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Official Full Name
lecithin-cholesterol acyltransferase
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Overview
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. -
Synonyms
LCAT; lecithin-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase; LCAT_HUMAN; Lecithin cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phospholipid cholesterol acyltransferase; Phospholipid-cholesterol acyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- Flag
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LCAT Related Articles
LCAT involved in several pathways and played different roles in them. We selected most pathways LCAT participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | GPAT2;EPT1;PLA2G16;AGPAT1;GPD1;AGPAT9;CRLS1;LPCAT4;DGKD |
LCAT has several biochemical functions, for example, apolipoprotein A-I binding, phosphatidylcholine-sterol O-acyltransferase activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LCAT itself. We selected most functions LCAT had, and list some proteins which have the same functions with LCAT. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
apolipoprotein A-I binding | LCAT;ABCA1;SCARB1;ABCA1B |
phosphatidylcholine-sterol O-acyltransferase activity | |
phospholipase A2 activity | PRDX6;PLA2G4AA;OC90;PLA2G16;ABHD3;PNPLA3;PLA2G2F;PLA2G10;PLB1 |
protein binding | EIF2B1;UBA52;CNIH2;MT2A;FRAS1;TOMM70A;C22orf29;KEAP1;TLR3 |
LCAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LCAT.
APOA1
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