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  • Official Full Name
  • lecithin-cholesterol acyltransferase
  • Background
  • This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
  • Synonyms
  • LCAT; lecithin-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase; LCAT_HUMAN; Lecithin cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phospholipid cholesterol acyltransferase; Phospholipid-cholesterol acyltransferase
Cat.#:LCAT-1013HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human LCAT, Flag-tagged
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Cat.#:LCAT-1363HTag:Fc
Source (Host):Human Embryonic Kidney 293 cellsSpecies:Human
Product nameRecombinant Human Lecithin-Cholesterol Acyltransferase, Flag-tagged
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Cat.#:LCAT-526HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LCAT Protein, His-tagged
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Cat.#:LCAT-7117HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCAT, His-tagged
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Cat.#:LCAT-8326HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human LCAT, Flag tagged
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Cat.#:Lcat-1676MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lcat protein, His-tagged
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Cat.#:Lcat-600MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lcat protein, His-tagged
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Cat.#:LCAT-8980MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LCAT Protein
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Cat.#:Lcat-1677RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lcat protein, His-tagged
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Cat.#:LCAT-5523CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LCAT
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Cat.#:LCAT-4809HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LCAT 293 Cell Lysate
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Cat.#:Kit-0507Tag:N/A
Source (Host):Species:
Product nameLCAT Activity Fluorometric Assay Kit
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Involved Pathway

LCAT involved in several pathways and played different roles in them. We selected most pathways LCAT participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
CRLS1; ETNPPL; LPIN1; ADPRM; AGPAT9L; PMT; LPCAT4; PHYKPL; AGPAT1; CDS2

Protein Function

LCAT has several biochemical functions, for example, apolipoprotein A-I binding, phosphatidylcholine-sterol O-acyltransferase activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LCAT itself. We selected most functions LCAT had, and list some proteins which have the same functions with LCAT. You can find most of the proteins on our site.
Function
Related Protein
Function apolipoprotein A-I binding
Related Protein LCAT; SCARB1; ABCA1; ABCA1B
Function phosphatidylcholine-sterol O-acyltransferase activity
Related Protein LCAT
Function phospholipase A2 activity
Related Protein PLA2G6; PLA2G1B; PLA2G12B; PLA2G2A; PLA2G16; PLB1; PLA2G4AA; PNPLA3; PLA2G4D; PLA2G2E
Function protein binding
Related Protein CD4; TSSK4; ZKSCAN1; KLF17; SLC9A3; ETS1; C16orf79; RBFA; AGPAT4; ATMIN

Interacting Protein

LCAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LCAT.
APOA1

LCAT Related Articles

Takahashi, S; Hiromura, K; et al. Nephrotic Syndrome Caused by Immune-Mediated Acquired LCAT Deficiency. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 24:1305-1312(2013).
Kwiterovich, PO; et al. Diagnosis and Management of Familial Dyslipoproteinemias. CURRENT CARDIOLOGY REPORTS 15:-(2013).