lmx1b
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  • Official Full Name
  • LIM homeobox transcription factor 1, beta
  • Background
  • This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1;homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the;normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and;dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively;spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • LMX1B; LIM homeobox transcription factor 1, beta; NPS1; LIM homeobox transcription factor 1-beta; LMX-1.2; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX1.2; MGC138325; MGC142051
Cat.#:LMX1B-237HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LMX1B, His-tagged
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Cat.#:LMX1B-600HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LMX1B, His-tagged
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Cat.#:LMX1B-9165MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LMX1B Protein
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Cat.#:LMX1B-6910CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LMX1B
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Cat.#:LMX1B-383HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human LMX1B lysate
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Involved Pathway

LMX1B involved in several pathways and played different roles in them. We selected most pathways LMX1B participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMX1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
SIDS Susceptibility Pathways
RUNX3; MAZ; MAP2; POU2F2; YBX1; SNTA1; TPH2; PHOX2A; MBD1; SST

Protein Function

LMX1B has several biochemical functions, for example, protein binding, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMX1B itself. We selected most functions LMX1B had, and list some proteins which have the same functions with LMX1B. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein FBXO9; ZFPL1; KIAA1199; HOOK1; MCM2; EIF2AK2; THG1L; MKI67; UBE2N; C17orf59
Function sequence-specific DNA binding
Related Protein HOXA3A; FOXI3A; RREB1; ZNF500; FOXE1; BHLHE22; NFE2L1B; DMRT2; FOXO1; PAX7B
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZIC2; GLIS2; CREB5; PFDN1; IKZF5; ZNF613; SOX2; PHOX2A; NFE2L3; HOXC6A
Function zinc ion binding
Related Protein CA1; MDM4; PHF11; RNF125; FHL3B; ADAM30; LHX1; MMEL1; TRIM35-24; ZFAND5A

Interacting Protein

LMX1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMX1B here. Most of them are supplied by our site. Hope this information will be useful for your research of LMX1B.
CDC37; LDB1

LMX1B Related Articles

Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
Miller, RL; Knuepfer, MM; et al. FOS-ACTIVATION OF FOXP2 AND LMX1B NEURONS IN THE PARABRACHIAL NUCLEUS EVOKED BY HYPOTENSION AND HYPERTENSION IN CONSCIOUS RATS. NEUROSCIENCE 218:110-125(2012).