LNPEP
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Official Full Name
leucyl/cystinyl aminopeptidase -
Overview
IRAP (also known as LNPEP) was originally described as an insulin-responsive aminopeptidase found in Glut4-containing vesicles. It is essentially always in the same compartments as Glut4 and has identical insulin-stimulated translocation patterns as Glut4 Aminopeptidase, Bacterial leucyl aminopeptidase, EC 3.4.11.10; Aeromonas proteolytica aminopeptidase; EC 3.4.11.1; EC 3.4.11.5; LAP; LAPEP; PEPS; Leucine aminopeptidase; Leucyl aminopeptidase; Peptidase S; Proline aminopeptidase; Prolyl aminopeptidase; leucine aminopeptidase 3; leucyl aminopeptidase; leucine aminopeptidase; leucyl peptidase; peptidase S; cytosol aminopeptidase; cathepsin III; L-leucine aminopeptidase; leucinaminopeptidase; leucinamide aminopeptidase; FTBL proteins; proteinates FTBL; aminopeptidase II; aminopeptidase III; aminopeptidase I. -
Synonyms
LNPEP;leucyl/cystinyl aminopeptidase;leucyl-cystinyl aminopeptidase;CAP;cystinyl aminopeptidase;P LAP;placental leucine aminopeptidase;PLAP;otase;oxytocinase;vasopressinase;AT (4) receptor;angiotensin IV receptor;insulin-regulated aminopeptid;Aeromonas Aminopeptidase;Aminopeptidase protein;Aminopeptidase;Bacterial leucyl aminopeptidase;EC 3.4.11.10;Aeromonas proteolytica aminopeptidase;EC 3.4.11.1;EC 3.4.11.5;LAP;LAPEP;PEPS;Leucine aminopeptidase;Leucyl aminopeptidase;Peptidase S;Proline aminopeptidase;Prolyl aminopeptidase;leucine aminopeptidase 3;leucyl peptidase;cytosol aminopeptidase;cathepsin III;L-leucine aminopeptidase;leucinaminopeptidase;leucinamide aminopeptidase;FTBL proteins;proteinates FTBL;aminopeptidase II;aminopeptidase III;aminopeptidase I
Recombinant Proteins
- Human
- Aeromonas
- Zebrafish
- Rat
- Mouse
- HEK293
- Aeromonas Proteolytica
- Mammalian Cells
- E.coli
- DDK
- Myc
- Non
- His
- Avi
- Fc
- Flag
Involved Pathway
LNPEP involved in several pathways and played different roles in them. We selected most pathways LNPEP participated on our site, such as Renin-angiotensin system, which may be useful for your reference. Also, other proteins which involved in the same pathway with LNPEP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | ATP6AP2,ACE,ENPEP,KLK1B5,MRGPRD,PREP,PRCP,MME,NLN,CPA3 |
Protein Function
LNPEP has several biochemical functions, for example, aminopeptidase activity,metalloaminopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LNPEP itself. We selected most functions LNPEP had, and list some proteins which have the same functions with LNPEP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | PHEX,TPP2,ERAP1,CTSL2,DPP9,BLMH,LTA4H,DNPEP,METAP2B,RNPEP |
| protein binding | TAF1C,GLS2,RPUSD3,HADHA,UBE4A,TRAF4,ELMO2,BLCAP,POU4F1,UBC |
| peptide binding | CRIP1,GNRHR2,H2-Q10,Npepo,RPS6KB1,RNPEP,NLN,OXTRL,NUP98,CCKAR |
| metallopeptidase activity | ANPEPA,MMP14B,MYSM1,CNDP2,MMP9,AGBL4,MEP1A.1,ACE,C6AST4,ADAMTS16 |
| zinc ion binding | ZFP326,ZSWIM2,TP53,UQCRC2A,NR2F6B,LIMD2,DEF8,MME,ZCRB1,DDX58 |
| metalloaminopeptidase activity | LTA4H,Npepo,METAP2B,ERAP1,METAP2A,TRHDE,ENPEP,RNPEP,XPNPEP1,ANPEP |
Interacting Protein
LNPEP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LNPEP here. Most of them are supplied by our site. Hope this information will be useful for your research of LNPEP.
TCF4;REL;FATE1;TNKS2;argS;b3xyc5_sollc;cona_canen;Junb;CANX;HEATR3;TMEM263;GCC1;DROSHA;NDUFA13
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References
- Haralambieva, IH; Oberg, AL; et al. High-Dimensional Gene Expression Profiling Studies in High and Low Responders to Primary Smallpox Vaccination. JOURNAL OF INFECTIOUS DISEASES 206:1512-1520(2012).
