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LTB

  • Official Full Name

    lymphotoxin beta (TNF superfamily, member 3)

  • Overview

    Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    LTB; lymphotoxin beta (TNF superfamily, member 3); TNFC; lymphotoxin-beta; p33; TNFSF3; LT beta; lymphotoxin beta; tumor necrosis factor C; TNF-C; LT-beta; OTTHUMP00000029185; OTTHUMP00000215145; tumor necrosis factor ligand superfamily member 3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chimpanzee
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LTB-285H Recombinant Human LTB, StrepII-tagged Human Cell Strep II 49-244, 196 a.a.
Mouse LTB-9344M Recombinant Mouse LTB Protein Mammalian Cell His
Mouse Ltb-7122M Recombinant Mouse Ltb protein, His-tagged E.coli His Ile58~Met304
Mouse LTB-5235M Recombinant Mouse LTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LTB-5235M-B Recombinant Mouse LTB Protein Pre-coupled Magnetic Beads HEK293
Rat Ltb-1750R Recombinant Rat Ltb Protein, His-tagged E.coli N-His Ala155-Val305
Chimpanzee LTB-4588C Recombinant Chimpanzee LTB protein, His-tagged E.coli His 49-244aa
Chimpanzee LTB-4589C Recombinant Chimpanzee LTB protein, His-SUMO-tagged E.coli His-SUMO 49-244aa
Cynomolgus Monkey LTB-1190C Recombinant Cynomolgus LTB Protein, His-tagged Insect Cell His
Mus musculus (Mouse) RFL11585MF Recombinant Full Length Mouse Lymphotoxin-Beta(Ltb) Protein, His-Tagged E.coli expression system His Full Length (1-306)
Rhesus Macaque LTB-2590R Recombinant Rhesus monkey LTB Protein, His-tagged Mammalian Cell His
Rhesus Macaque LTB-2410R Recombinant Rhesus Macaque LTB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LTB-2410R-B Recombinant Rhesus Macaque LTB Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LTB Related Articles
  • LTB Related Research Area

LTB involved in several pathways and played different roles in them. We selected most pathways LTB participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionPdgfa&Pdgfb;AMH;VEGFC;BMPR2;PRL;TGFB2;IFNA3;IL20RB;FLT3LG
NF-kappa B signaling pathwayTICAM2;TRAF2;CCL4;CCL13;CCL19;TNFSF13B;CFLAR;RIPK1;PLAU
Rheumatoid arthritisFLT1;CCL5;HLA-DRB5;IL11;IL1A;HLA-DMB;CD80;ATP6V1E1;ITGB2L

LTB has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTB itself. We selected most functions LTB had, and list some proteins which have the same functions with LTB. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP2;IL1A;IFNA4;LFT1;RNF207B;Il23a; Il12b;IL6;GDF3;Ifnl2
receptor bindingBAAT;SLC9A3R2;INSL3;ECH1;CADM3;CD70;LBP;CADM1A;AMACR
tumor necrosis factor receptor bindingTNFSF10L3;ERAP1;TNFSF13;TNFB;TNFSF9;CD40LG;EDA;TRADD;TRAF3

LTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTB here. Most of them are supplied by our site. Hope this information will be useful for your research of LTB.

TNFSF14; galK; q7ch26_yerpe; isdC; rapA

Qi, YL; Kang, HT; et al. Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the innmunogenicity of rabies virus-like particles in mice and dogs. FRONTIERS IN MICROBIOLOGY 6:-(2015).
Lei, H; Peng, XJ; et al. Intranasal Immunization with Live Recombinant Lactococcus lactis Combined with Heat-Labile Toxin B Subunit Protects Chickens from Highly Pathogenic Avian Influenza H5N1 Virus. JOURNAL OF MEDICAL VIROLOGY 87:39-44(2015).
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