This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.
MAGEA8; melanoma antigen family A, 8; MAGE8; melanoma-associated antigen 8; cancer/testis antigen family 1; member 8; CT1.8; MAGE 8 antigen; MGC2182; MAGE8 antigen; Melanoma antigen family A 8; Melanoma associated antigen 8; MAGE-8 antigen; OTTHUMP00000024218; cancer/testis antigen 1.8; cancer/testis antigen family 1, member 8
MAGEA8 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEA8 itself. We selected most functions MAGEA8 had, and list some proteins which have the same functions with MAGEA8. You can find most of the proteins on our site.
Related Protein UBL5; SYNGR1A; SEZ6; TECRL; PALM1B; HHLA2; EPS8L3; ZNF24; LRRC55; GPR141
Function protein binding
Related Protein DIRAS3; DIP2A; HMGN2; GPBP1; NR1H3; USF2; SSX2; MOB1A; ZNF133; NEGR1
MAGEA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEA8.
BEX5; MAGEB4; LMO2; GCA; PKD2; MTUS2; LXN
MAGEA8 Related Articles
Zhang, QM; He, SJ; et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3918-3927(2014).
Morgan, RA; Chinnasamy, N; et al. Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy. JOURNAL OF IMMUNOTHERAPY 36:133-151(2013).