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MAP3K6

Official Full Name

mitogen-activated protein kinase kinase kinase 6
Overview

This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
Synonyms

MAP3K6; mitogen-activated protein kinase kinase kinase 6; apoptosis signal regulating kinase 2; ASK2; MAPKKK6; MEKK6; apoptosis signal-regulating kinase 2; MGC20114; MGC125653;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K6-1429H	Active Recombinant Human MEKK6, GST-tagged	Sf9 Insect Cell	GST	620-950 aa	Inquiry
Mouse	MAP3K6-9516M	Recombinant Mouse MAP3K6 Protein	Mammalian Cell	His		Inquiry
Mouse	MAP3K6-5334M	Recombinant Mouse MAP3K6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MAP3K6-5334M-B	Recombinant Mouse MAP3K6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Map3k6-8082R	Recombinant Rat Map3k6 protein, His & T7-tagged	E.coli	His/T7	Thr649~Leu907 (Accession # D3ZFL3)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAP3K6 Related Articles

MAP3K6 involved in several pathways and played different roles in them. We selected most pathways MAP3K6 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	CACNB4;PPP3R1B;KCNA3;MKNK2;TRP53;CACNA1C;TAB2;RELA;FGF14

MAP3K6 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K6 itself. We selected most functions MAP3K6 had, and list some proteins which have the same functions with MAP3K6. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	UCKL1A;NMRK2;WEE1;CCC2;AARSD1;ATP12A;ACTG1;PRKCBB;NSFB
MAP kinase kinase kinase activity	MAP3K4;MOS;TAOK1;TAOK3;YSK4;MAP3K14;MAP3K6;BRAF;TAOK2
magnesium ion binding	FAN1;ZNF143B;FARS2;PTEN;PKM2;RPS6KA4;NLK;NT5C1AA;ENO3

MAP3K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K6.

MAP3K5; PRKAB2; HSP90AB1; PRKAA2; glcD3; asnO3; YWHAG

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).

Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).