mapk6
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  • Official Full Name
  • mitogen-activated protein kinase 6
  • Background
  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Encodes a MAP kinase induced by pathogens, ethylene biosynthesis, oxidative stress and osmotic stress.Also involved in ovule development. Homozygous mutants in a MPK3 heterozygous background are female sterile due to defects in integument development.MPK6 appears to be associated with the microsomal compartment and may be involved in mediating secretory processes.
  • Synonyms
  • MAPK6; mitogen-activated protein kinase 6; PRKM6; ERK3; HsT17250; p97MAPK; ERK-3; MAPK 6; p97-MAPK; MAP kinase 6; MAP kinase isoform p97; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; extracellular signal-regulated kinase 3; ex; MPK6; Arabidopsis thaliana MPK6; AtMPK6; MAP kinase 6 (MPK6); FUNCTIONS IN: MAP kinase activity, kinase activity; INVOLVED IN: in 20 processes; LOCATED IN: trans-Golgi network, preprophase band, phragmoplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase 3 (TAIR:AT3G45640.1); Has 124968 Blast hits to 123484 proteins in 4565 species: Archae - 94; Bacteria - 13025; Metazoa - 47222; Fungi - 12634; Plants - 30512; Viruses - 574; Other Eukaryotes - 20907 (source: NCBI BLink).; ATMAPK6; F18O19.10
Cat.#:MAPK6-644HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK6 Protein (1-721 aa), His-SUMO-tagged
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Cat.#:MAPK6-284HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK6 protein, His/MBP-tagged
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Cat.#:MAPK6-285HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK6 protein, His/MBP-tagged
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Cat.#:MAPK6-659HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK6 Protein, His-tagged
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Cat.#:MAPK6-742HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK6, GST-tagged
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Cat.#:MAPK6-9536MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK6 Protein
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Cat.#:MAPK6-3575RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK6 Protein
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Cat.#:MAPK6-2263CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK6
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Cat.#:MAPK6-4420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK6
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Cat.#:MAPK6-4492HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK6 293 Cell Lysate
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Involved Pathway

MAPK6 involved in several pathways and played different roles in them. We selected most pathways MAPK6 participated on our site, such as Focal Adhesion, Insulin Signaling, Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal Adhesion
COL24A1; PAK2A; ITGA11A; MYL12.2; RAC3A; FLT4; FYNA; VEGFAB; PAK3; ITGA2
Insulin Signaling
GRB10; MAPK4; KIF5B; INPP4AA; REG1A; MAP3K10; FLOT1; SNAP25A; GRB14; MAP3K2
Integrin-mediated cell adhesion
CAPN10; CAPN5; TNS1; MAPK4; CAPN11; MYLK2; SEPP1A; CAPN3; CAPN9; SEPP1
MAPK family signaling cascades
CDC42EP1B; MAPK4; CDC42EP3; CDC42EP2; CDC42EP5; IGF2BP1; MAPK6; SEPT7
MAPK signaling pathway
ARRB2; FGF1; CACNA1DA; DUSP3; FGF8A; ACVR1C; PPP5C; GADD45BB; FGF12; AKT2
MAPK6/MAPK4 signaling
CDC42EP3; CDC42EP1B; MAPK6; MAPK4; CDC42EP2; CDC42EP5; SEPT7; IGF2BP1
Regulation of Actin Cytoskeleton
MYLPFB; MYLK; ITGAE; FGF13B; PPP1CBL; FGFR4; F2; CDC42L2; CDC42L; RRAS2
Signal Transduction
ABCA4A; SAGB; PROK2; TAS2R7; IQGAP3; AXL; TAC3; LRIG1; PRICKLE1B; ADAM12

Protein Function

MAPK6 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK6 itself. We selected most functions MAPK6 had, and list some proteins which have the same functions with MAPK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DNAJA3B; UBE2L3A; TSSK1; ADK; KALRN; STK17A; ATP6V1BA; STK26; CDK3; PSMC4
Function MAP kinase activity
Related Protein MAPK6; MAPK4; NLK; MAPK14; MAPK14B; NLK2; MAPK1; NLK1; MAPK3; MAPK15
Function protein binding
Related Protein GTF2H4; ZFP488; FAM65B; CENPA; TCF12; CLDN8; NUDT21; MAP2K1; SPINK1; C21orf7
Function protein heterodimerization activity
Related Protein APITD1; HIST1H4H; MAFG; HIST1H2BK; CYBB; BDKRB2; CA; NFYB; KATNA1; HIST1H2AK
Function protein kinase binding
Related Protein CDKN2C; TRPV4; SKAP1; CRY1; PPP1CB; TOM1L1; ACVRL1; LSM2; PLCG1; DLG1L
Function protein serine/threonine kinase activity
Related Protein DCLK3; NIM1K; PRKCHB; OXSR1B; TRIOA; TLK1B; PAK3; ATM; PAK4; PDIK1L

Interacting Protein

MAPK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK6.
MAPKAPK5; vif; EEF1D; PDLIM1; HIP1; SOCS3; DSCR3; ARPC3; PLSCR1; STX7; PHGDH; MAP3K7; FOXO3; SMAD6

MAPK6 Related Articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).