Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

MAPK6

  • Official Full Name

    mitogen-activated protein kinase 6

  • Overview

    The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Encodes a MAP kinase induced by pathogens, ethylene biosynthesis, oxidative stress and osmotic stress.Also involved in ovule development. Homozygous mutants in a MPK3 heterozygous background are female sterile due to defects in integument development.MPK6 appears to be associated with the microsomal compartment and may be involved in mediating secretory processes.
  • Synonyms

    MAPK6; mitogen-activated protein kinase 6; PRKM6; ERK3; HsT17250; p97MAPK; ERK-3; MAPK 6; p97-MAPK; MAP kinase 6; MAP kinase isoform p97; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; extracellular signal-regulated kinase 3; ex; MPK6; Arabidopsis thaliana MPK6; AtMPK6; MAP kinase 6 (MPK6); FUNCTIONS IN: MAP kinase activity, kinase activity; INVOLVED IN: in 20 processes; LOCATED IN: trans-Golgi network, preprophase band, phragmoplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase 3 (TAIR:AT3G45640.1); Has 124968 Blast hits to 123484 proteins in 4565 species: Archae - 94; Bacteria - 13025; Metazoa - 47222; Fungi - 12634; Plants - 30512; Viruses - 574; Other Eukaryotes - 20907 (source: NCBI BLink).; ATMAPK6; F18O19.10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|SUMO
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK6-742H Recombinant Human MAPK6, GST-tagged E.coli GST 7-350aa
Human MAPK6-285H Recombinant Human MAPK6 protein, His/MBP-tagged E.coli His/MBP 299-526 aa
Human MAPK6-284H Recombinant Human MAPK6 protein, His/MBP-tagged E.coli His/MBP 538-721 aa
Human MAPK6-659H Recombinant Human MAPK6 Protein, His-tagged E.coli His
Human MAPK6-4492HCL Recombinant Human MAPK6 293 Cell Lysate HEK293 N/A
Human MAPK6-644H Recombinant Human MAPK6 Protein (1-721 aa), His-SUMO-tagged E.coli His/SUMO 1-721 aa
Human MAPK6-2419H Recombinant Human MAPK6 Protein, His-tagged E.coli N-His Met1-Met316
Human MAPK6-01H Recombinant Human MAPK6 Protein, GST-tagged Insect Cell GST
Human MAPK6-0109H Recombinant Human MAPK6 Protein (M9-I327), His tagged E.coli His M9-I327
Human MAPK6-0108H Recombinant Human MAPK6 Protein (M9-I327), Tag Free E.coli No tag M9-I327
Human MAPK6-4992H Recombinant Human MAPK6 Protein (Met1-Met316), His tagged E.coli His Met1-Met316
Mouse MAPK6-9536M Recombinant Mouse MAPK6 Protein Mammalian Cell His
Mouse MAPK6-5352M-B Recombinant Mouse MAPK6 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAPK6-5352M Recombinant Mouse MAPK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAPK6-3575R Recombinant Rat MAPK6 Protein Mammalian Cell His
Rat MAPK6-3231R-B Recombinant Rat MAPK6 Protein Pre-coupled Magnetic Beads HEK293
Rat MAPK6-3231R Recombinant Rat MAPK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MAPK6-4420Z Recombinant Zebrafish MAPK6 Mammalian Cell His
Chicken MAPK6-2263C Recombinant Chicken MAPK6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK6 Related Articles
  • MAPK6 Related Research Area

MAPK6 involved in several pathways and played different roles in them. We selected most pathways MAPK6 participated on our site, such as Focal Adhesion, Insulin Signaling, Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Focal AdhesionIGF1R;PIK3R3B;GRB2;BIRC2;ITGA1;LAMB2;ITGB3B;MYLPFA;RAPGEF1
Insulin SignalingSTXBP2;MAP3K10;MAP3K9;GSK3AB;GRB10;INPP4AA;MAPK4;MAP3K2;KIF5B
Integrin-mediated cell adhesionMYLK2;CAPN3;MAPK4;CAPN3A;CAPN5;CAPNS1;MAPK6;TNS1;CAPN11
MAPK family signaling cascadesCDC42EP5;MAPK4;CDC42EP1B;IGF2BP1;MAPK6;CDC42EP3;SEPT7;CDC42EP2
MAPK signaling pathwayMAPK1;JUND;NTRK2;MAP4K1;CACNA1SB;RAP1AB;EGFRA;MAP2K2A;MYCB
MAPK6/MAPK4 signalingCDC42EP1B;CDC42EP5;SEPT7;CDC42EP2;MAPK6;IGF2BP1;MAPK4;CDC42EP3
Regulation of Actin CytoskeletonPPP1CBL;PXNA;PIK3R3A;ARHGEF4;VCLA;FGF20;PIP5K1B;ITGAE;ABI2B
Signal TransductionOPN4A;GPR37L1;ARHGAP8;QRFPR;METAP2A;RGS6;USP4;DCLRE1B;GPR4

MAPK6 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK6 itself. We selected most functions MAPK6 had, and list some proteins which have the same functions with MAPK6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCA1B;NRBP2;PTK7;RPS6KA3;MAP4K2;LIMK1;TRPM4;PIM1;MSH3
MAP kinase activityMAPK11;MAPK8B;MAPK1;MAPK8A;MAPK3;MAPK14B;MAPK15;MAPK12A;MAPK14A
protein bindingBIN3;MASP1;CSF3R;CHCHD2;MYOCD;RGS8;PRDM10;RET;HAUS1
protein heterodimerization activityPdgfa&Pdgfb;SMC3;VAPB;HIST1H3G;DMRT3;P4HB;CUL5;MAPK6;TAF11
protein kinase bindingJIP1;SPAG16;NEFH;MAPT;CACNB3;XBP1;FBXO5;FGF19;MVP
protein serine/threonine kinase activitySTK38L;CSNK1D;CSNK1G2;MAPK12A;STK4;ACVR2AA;ULK1;BMP2K;MOK

MAPK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK6.

MAPKAPK5; vif; EEF1D; PDLIM1; HIP1; SOCS3; DSCR3; ARPC3; PLSCR1; STX7; PHGDH; MAP3K7; FOXO3; SMAD6

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All MAPK6 Products

Required fields are marked with *

My Review for All MAPK6 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends